Quantitatively describing the signal transduction process is important for understanding the mechanism of signal regulation
in cells, and thus, poses both a challenge and an opportunity for chemical and biochemical engineers. An artificial neural
network (ANN), in which we took the signal molecules as neural nodes, was constructed to simulate the generation of active
oxygen species (AOS) in Taxus chinensis cells induced by a bio-elicitor. The relative contents of AOS in cells predicted by the ANN model agreed well with the experimental
data and three notable stages of AOS increase were observed from the 3D figure of AOS generation. The robustness of AOS trajectories
indicated that signal regulation in vivo was an integral feedback control model that ensured the adaptation of Taxus chinensis to environmental stress. The artificial neural network was able to predict taxol production as well as determine the optimal
concentration of oligosaccharides needed for it. 相似文献
A non-iterative identification method with parameterization of the unknown dead-zone is proposed for Hammerstein systems in presence of asymmetric dead-zone nonlinearities.The canonical parameterized model which is a single expression without segmentation is utilized to describe the dead-zone,based on which a universal-type parametric model can be established to approximate the entire system.This model can be established without separating the nonlinear part from the linear part.The dead-zone parameters and the coefficients in the linear transfer function can be estimated simultaneously according to the proposed algorithm.Numerical experiments are presented to illustrate the effectiveness of the proposed scheme. 相似文献
Heuristic algorithms (HAs) are widely used in multi-objective reservoir optimal operation (MOROO) due to the rapidity of the calculation and simplicity of their design. The literature usually focuses on one or two categories of HAs and simply reviews the state of the art. To provide an overall understanding and a specific comparison of HAs in MOROO, differential evolution (DE), particle swarm optimisation (PSO), and artificial physics optimisation (APO), which serve as typical examples of the three categories of HAs, are compared in terms of the development and applications using a designed experiment. Besides, the general model with constraints and fitness function, and the solution process using a hybrid feasible domain restoration method and penalty function method are also presented. Taking a designed experiment with multiple scenarios, the mean average of the optimal objective function values, the standard deviation of optimal objective function values, the mean average of the computational time, and population diversity are used for comparisons. Results of the comparisons show that (a) the problem of optimal multipurpose reservoir long-term operation is a mathematic programming problem with narrow feasible region and monotonic objective function; (b) it is easy to obtain the same optimal objective function value, but different optimal solutions using HAs; and (c) comparisons do not result in a clear winner, but DE can be more appropriate for MOROO.