Loss of heterozygosity and overexpression of the p53 gene in ovarian carcinoma

Eight anticonvulsant drugs-including clonazepam, diazepam and phenobarbital-were tested for their effects on GABA-stimulated chloride uptake in rat cerebral cortical microsacs (unfiltered synaptoneurosomes). "Mid" and "high" therapeutic concentrations were screened, and, if significant enhancement was found, full concentration-response tests were done. In the initial screens, enhancement of GABA-stimulated uptake was found only with phenobarbital, clonazepam and diazepam. In subsequent concentration-response tests, the effects of phenobarbital were found to occur throughout the range of normal, anticonvulsant concentrations, whereas the effects of clonazepam and diazepam were observed only above the concentrations normally used for the chronic control of seizures or anxiety. These data suggest that phenobarbital's anticonvulsant effects are mediated via the GABAA receptor complex, but that the low-dose effects of the benzodiazepines may be mediated via some other mechanism.     

On knowledge networks in science: collaboration among equals

Knowledge is produced from labor and existing knowledge as embodied in documents and persons. Through knowledge networks, researchers can utilize knowledge inputs from other scientists. This paper examines institutions for knowledge exchange and attempts a formal analysis of scientific exchange in passive and active collaboration.I am indebted to Professors Tawada, Sakai, Ohta and John Roy for helpful comments and corrections.This paper was presented in draft form at an International Workshop on Trade, Knowledge and the Network Economy, held in December 1992 in Mallacoota, Australia.     

A criterion for plane strain,fully plastic,quasi-steady crack growth

Plane strain fracture by hole growth in ordinary-sized parts of low-to-medium strength steels is essentially rigid-plastic, and may be approximated as non-hardening. Quasi-steady crack growth for such materials is predicted for crack-tip fields approximated by a pair of slip lines, such as unequally grooved specimens in tension and deep singly-face-cracked specimens under combined bending and tension. The crack growth increment a is given in terms of material parameters, far-field geometry, and loadings and their increments.For the rigid-plastic, non-hardening approximation, stress and strain increment fields for growing cracks are identical to those for stationary cracks. For fields with a pair of symmetric slip-lines, the flanks of the decohering zone turn out to be rigid, and the decohering zone does not affect the crack-tip opening angle (CTOA), which then depends only on the micromechanisms of hole nucleation, growth and linkage by flow localization or fine cracking. These mechanisms are in turn approximately controlled by the near-field plasticity parameters: the angle of the slip plane _s, and the normal stress and displacement increment across the slip plane _s and u_s. Note the three-parameter characterization of the near-tip fields, in contrast to the one- or two-parameter characterization in elastic or nonlinear elastic fracture mechanics.A sliding off and shear-cracking model for a growing crack, based on a hole growth equation, gives an approximate CTOA in terms of _s, _s, and material parameters. When hole nucleation strain is negligible, the estimated CTOA exhibits an inverse exponential dependence on _s and a higher order parabolic dependence on _s. For a given material, a series of fully plastic crack growth experiments is suggested to determine the approximate material parameters needed to characterize the dependence of CTOA on _s and _s, or from kinematics, of the shear strain behind the slip plane, _f, on _s.     

Heat conduction in Ba1?xKxBiO3

We have investigated heat conduction of single crystal Ba_1–xK_xBiO₃ in the temperature range of 2–300 K and in a magnetic field of up to 6 Tesla. Temperature dependence of thermal conductivity(T) reveals the participation of both electrons and phonons with their relative contributions that depend critically on the potassium doping concentration. Crystals underdoped with potassium (samples with higherT _c) exhibit a strong suppression of and a glass-like temperature dependence. In contrast, those with a higher potassium content (lowerT _c) show an increase as temperature decreases with a peak near 23 K. Field dependence of(H) is also very sensitive to the level of potassium doping. Crystals exhibiting a large phonon contribution show an initial drop in(H) at low fields followed by a minimum and then a slow rise to saturation as the field increases. The initial drop is due to the additional phonon scattering by magnetic vortices as the sample enters a mixed state. The high field behavior of(H), arising from a continuous break-up of Cooper pairs, exhibits scaling which suggests the presence of an unconventional superconducting gap structure in this material.     

Superior Thermoelectric Performance of Textured Ca3Co4−xO9+δ Ceramic Nanoribbons

Calcium cobaltite Ca₃Co_4−xO_9+δ (CCO) is a promising p-type thermoelectric (TE) material for high-temperature applications in air. The grains of the material exhibit strong anisotropic properties, making texturing and nanostructuring mostly favored to improve thermoelectric performance. On the one hand multitude of interfaces are needed within the bulk material to create reflecting surfaces that can lower the thermal conductivity. On the other hand, low residual porosity is needed to improve the contact between grains and raise the electrical conductivity. In this study, CCO fibers with 100% flat cross sections in a stacked, compact form are electrospun. Then the grains within the nanoribbons in the plane of the fibers are grown. Finally, the nanoribbons are electrospun into a textured ceramic that features simultaneously a high electrical conductivity of 177 S cm⁻¹ and an immensely enhanced Seebeck coefficient of 200 µV K⁻¹ at 1073 K are assembled. The power factor of 4.68 µW cm⁻¹ K⁻² at 1073 K in air surpasses all previous CCO TE performances of nanofiber ceramics by a factor of two. Given the relatively high power factor combined with low thermal conductivity, a relatively large figure-of-merit of 0.3 at 873 K in the air for the textured nanoribbon ceramic is obtained.     

How can I help you? Design principles for task-oriented speech dialog systems in customer service

Organizations are increasingly delegating customer inquiries to speech dialog systems (SDSs) to save personnel resources. However, customers often report frustration when interacting with SDSs due to poorly designed solutions. Despite these issues, design knowledge for SDSs in customer service remains elusive. To address this research gap, we employ the design science approach and devise a design theory for SDSs in customer service. The design theory, including 14 requirements and five design principles, draws on the principles of dialog theory and undergoes validation in three iterations using five hypotheses. A summative evaluation comprising a two-phase experiment with 205 participants yields positive results regarding the user experience of the artifact. This study contributes to design knowledge for SDSs in customer service and supports practitioners striving to implement similar systems in their organizations.

     

Two-stage stochastic master production scheduling under demand uncertainty in a rolling planning environment

This paper proposes a scenario-based two-stage stochastic programming model with recourse for master production scheduling under demand uncertainty. We integrate the model into a hierarchical production planning and control system that is common in industrial practice. To reduce the problem of the disaggregation of the master production schedule, we use a relatively low aggregation level (compared to other work on stochastic programming for production planning). Consequently, we must consider many more scenarios to model demand uncertainty. Additionally, we modify standard modelling approaches for stochastic programming because they lead to the occurrence of many infeasible problems due to rolling planning horizons and interdependencies between master production scheduling and successive planning levels. To evaluate the performance of the proposed models, we generate a customer order arrival process, execute production planning in a rolling horizon environment and simulate the realisation of the planning results. In our experiments, the tardiness of customer orders can be nearly eliminated by the use of the proposed stochastic programming model at the cost of increasing inventory levels and using additional capacity.     

Dynamic material properties of wood subjected to low-velocity impact

This article studied the effects of low-velocity impact on the failure stresses and stiffness using a pendulum test. The specimens were of variable depth (20, 30, and 40 mm), a width of 50 mm, length of 650 mm, and span-length of 480 mm. The smallest specimen depth was similar to specimen sizes tested in the literature used to create the duration of load curve, while the largest specimen depth are considered structural size specimens. The impact was predicted using a numerical approach with Euler–Bernoulli beam, as well as Timoshenko beam theory, with a plastic contact law. The models were validated for impact from a low release-angle (where the beam remained elastic), but could use improvement for the force prediction at a high incidence velocity. The measured force signals were used as forcing functions to obtain the dynamic failure stresses for all of the evaluated specimens, and the Timoshenko–Goens–Hearmon Method to derive the dynamic E. The resulting strain rates ranged from 9.11?×?10^?5 s^?1 for the quasi-static specimens up to 25 s^?1 for the greatest incidence velocity. The results from this study suggest different duration of load factors than the Madison Curve, influencing the design of structures subjected to dynamic loading.