Role of shear stress and stretch in vascular mechanobiology

Blood vessels are under constant mechanical loading from blood pressure and flow which cause internal stresses (endothelial shear stress and circumferential wall stress, respectively). The mechanical forces not only cause morphological changes of endothelium and blood vessel wall, but also trigger biochemical and biological events. There is considerable evidence that physiologic stresses and strains (stretch) exert vasoprotective roles via nitric oxide and provide a homeostatic oxidative balance. A perturbation of tissue stresses and strains can disturb biochemical homeostasis and lead to vascular remodelling and possible dysfunction (e.g. altered vasorelaxation, tone, stiffness, etc.). These distinct biological endpoints are caused by some common biochemical pathways. The focus of this brief review is to point out some possible commonalities in the molecular pathways in response to endothelial shear stress and circumferential wall stretch.     

Inkjet Printing—Process and Its Applications

In this Progress Report we provide an update on recent developments in inkjet printing technology and its applications, which include organic thin‐film transistors, light‐emitting diodes, solar cells, conductive structures, memory devices, sensors, and biological/pharmaceutical tasks. Various classes of materials and device types are in turn examined and an opinion is offered about the nature of the progress that has been achieved.     

Hydrocarbons and heavy metals in the different sewer deposits in the 'Le Marais' catchment (Paris, France): stocks, distributions and origins

The knowledge of the pollution stored in combined sewers is of prime importance in terms of management of wet weather flow pollution since sewer deposits play a significant role as source of pollution in combined sewer overflows. This work, which focused on the hydrocarbon (aliphatic and aromatic hydrocarbons) and metallic (Fe, Zn, Pb, Cu and Cd) pollution fixed to the different kinds of sewer deposits (gross bed sediment [GBS], organic layer [OL] and biofilm), was performed in order to provide a complete overview of the contaminant storage in the 'Le Marais' combined sewer (Central Paris, France). Firstly, our results have shown that, for all kinds of pollutants, a major part was stored in the GBS (87 to 98%), a lesser part in the OL (2 to 13%) and an insignificant part in the biofilm (<1%). These results demonstrated that the potential contribution of biofilm to wet weather pollution was negligible compared to the OL one. Secondly, the investigation of hydrocarbon fingerprints in each deposit has provided relevant information about contamination origins: (1) aliphatic hydrocarbon distributions were indicative of petroleum input in the GBS and reflected a mixture of biogenic and petroleum inputs in the OL and biofilm, (2) aromatic hydrocarbon distributions suggested an important pyrolytic contamination in all the deposits. Finally, the study of pollutant fingerprints in the different deposits and in the suspended solids going through the collector has shown that: (1) the suspended solids were the major component of OL and biofilm while urban runoff seemed to be the main transport mechanism introducing pollutants in the GBS and (2) the residence times in sewer of OL and biofilm were quite short compared to those for GBS.     

Joint source and channel coding for 3-D scene databases using vector quantization and embedded parity objects.

Three-dimensional graphic scenes contain various mesh objects in one geometric space where different objects have potentially unequal importance regarding display. This paper proposes an object-oriented system for efficiently coding and streaming 3-D scene databases in lossy and rate-constrained environments. Vector quantization (VQ) is exploited to code 3-D scene databases into multiresolution hierarchies. For the best distortion-rate performance, adaptive quantization precisions are allocated to different objects and different layers of each object based on a weighted distortion model. Upon transmission, scalably coded objects are delivered in respective packet sequences to preserve their manipulation independency. For packet loss resilience, a plurality of FEC codes are generated as "parity objects" parallel to graphic objects, which protect the graphic objects concurrently and also preferentially in regard to their unequal decoding importance. A rate-distortion optimization framework is then developed, which performs rate allocation between graphic objects and parity objects and generates the parity data properly. We show that, by treating graphic objects jointly and preferentially in source and channel coding while preserving their independencies in transport, the proposed system reduces the receiving distortion of the 3-D database significantly compared to conventional methods.     

Use of dolomite catalyst in biodiesel production via transesterification of waste cooking oil in oscillatory baffled reactor

Biodiesel has recently gained popularity due to its environmental issues and the fact that it is generated from renewable resources. However, the cost of the synthesis of biodiesel is the major impediment to commercialization. The utilization of leftover cooking oils as raw material, the adaptation of a continuous transesterification process, and the use of cheap catalysts are the major possibilities for investigating the cost of biodiesel. In this work, a dolomite catalyst was prepared from natural dolomite rocks and used for the evaluation of continuous transesterification of biodiesel from oleic acid as a model compound of waste cooking oil (WCO). The dolomite catalyst was prepared by activation under vacuum at a surface area of 34.5 m²/g. The characterization tests showed good thermal stability of the catalyst and evolution of the CaO and MgO compounds at high concentrations. A kinetic study was conducted to obtain kinetic parameters of catalytic transesterification of the WCO. The kinetic experiments were carried out at 298–333 K, and residence time up to 80 min. The results presented that the catalytic transesterification is the first-order reaction, and the activation energy was 43 kJ/mol. The oscillatory baffled reactor (OBR) was used to evaluate the dolomite catalyst for the continuous production of biodiesel via transesterification. The evaluation study was conducted at a methanol: oil mole ratio of 6:1 and the effect of different operation variables on oleic acid conversion to biodiesel was studied. These variables were temperature (323, 333, and 343 K), residence times (5–40 min), the amplitude of oscillation (2–8 mm), and frequency of oscillation (1, 2, 3, 4, and 4.3 Hz). The results showed an outstanding performance and stable activity of the dolomite catalyst as a conversion of 96% was obtained at 333 K, 4.3 Hz, 8 mm amplitude, and 40 min residence time.     

Effect of prestrain paths on mechanical behavior of dual phase sheet steel

The tensile and fatigue performance of dual phase (DP600) sheet steel was investigated with specimens, as-received, and with two different prestrain path conditions, uniaxial and plane strain. First, tensile tests of the as-received condition of DP600 were performed to obtain mechanical properties, specifically the uniform elongation, for determining the prestrain levels of the specimens. Then three prestrain levels from each strain path were applied onto the sheet steel. Tensile and fatigue specimens were prepared from the prestrained coupons. Mechanical properties were obtained from the uniaxial tests of the as-received and prestrained specimens for comparison. Fatigue testing was also conducted with strain controlled to acquire fatigue properties. The fatigue life curves were plotted as a function of strain range and Neuber factor. The uniaxially prestrained specimens exhibited higher fatigue strength than that of the as-received ones for the long life region, but the opposite effect was observed for the short life region of less than 10⁴ reversals.     

A Stochastic Chartist–Fundamentalist Model with Time Delays

A stochastic chartist?Cfundamentalist model of speculative asset dynamics in financial markets is developed. The model is represented by a stochastic delay-differential equation (SDDE). The SDDE is then solved using approximation and numerical Monte Carlo methods. The results show that for large time delays, the SDDE generates market-like stock price dynamics that reflect the memory effects of the time delay. The resultant dynamics agree with the empirical observation of the tendency of stock markets to deviate from pure random walk.     

Throughput optimization of cooperative non orthogonal multiple access

Telecommunication Systems - This paper derives the outage and packet error probabilities of Non Orthogonal Multiple Access (NOMA) systems. In the first time slot, the Base Station transmits a...     

A validated predictive model of coronary fractional flow reserve

Myocardial fractional flow reserve (FFR), an important index of coronary stenosis, is measured by a pressure sensor guidewire. The determination of FFR, only based on the dimensions (lumen diameters and length) of stenosis and hyperaemic coronary flow with no other ad hoc parameters, is currently not possible. We propose an analytical model derived from conservation of energy, which considers various energy losses along the length of a stenosis, i.e. convective and diffusive energy losses as well as energy loss due to sudden constriction and expansion in lumen area. In vitro (constrictions were created in isolated arteries using symmetric and asymmetric tubes as well as an inflatable occluder cuff) and in vivo (constrictions were induced in coronary arteries of eight swine by an occluder cuff) experiments were used to validate the proposed analytical model. The proposed model agreed well with the experimental measurements. A least-squares fit showed a linear relation as (Δp or FFR)_experiment = a(Δp or FFR)_theory + b, where a and b were 1.08 and −1.15 mmHg (r² = 0.99) for in vitro Δp, 0.96 and 1.79 mmHg (r² = 0.75) for in vivo Δp, and 0.85 and 0.1 (r² = 0.7) for FFR. Flow pulsatility and stenosis shape (e.g. eccentricity, exit angle divergence, etc.) had a negligible effect on myocardial FFR, while the entrance effect in a coronary stenosis was found to contribute significantly to the pressure drop. We present a physics-based experimentally validated analytical model of coronary stenosis, which allows prediction of FFR based on stenosis dimensions and hyperaemic coronary flow with no empirical parameters.