Experimental validation of a simple approximation to determine the linewidth of a laser from its frequency noise spectrum

Laser frequency fluctuations can be characterized either comprehensively by the frequency noise spectrum or in a simple but incomplete manner by the laser linewidth. A formal relation exists to calculate the linewidth from the frequency noise spectrum, but it is laborious to apply in practice. We recently proposed a much simpler geometrical approximation applicable to any arbitrary frequency noise spectrum. Here we present an experimental validation of this approximation using laser sources of different spectral characteristics. For each of them, we measured both the frequency noise spectrum to calculate the approximate linewidth and the actual linewidth directly. We observe a very good agreement between the approximate and directly measured linewidths over a broad range of values (from kilohertz to megahertz) and for significantly different laser line shapes.     

Occurrence of ochratoxin A in raw ham muscle,salami and dry-cured ham from pigs fed with contaminated diet

Pork meat-derived products can contribute to the overall ochratoxin A intake, either by carry-over effect, or by environmental mould population cross-contamination. In order to assess the role of these different contamination routes, a study was carried out with pigs challenged orally with OTA contaminated feed at subchronical level. After slaughtering, thighs and minced meat from control and treated groups were transformed into dry-cured hams and salami, respectively, which were analysed for OTA determination after ripening. From collected data, the carry-over in muscle was generally low, whereas a significant contribution to the OTA contamination in dry-cured hams was due to toxinogenic mould population growing on their surface during ripening. Finally, a survey of different types of dry-cured ham (n = 110), from the Italian market, was performed, showing the occurrence of OTA on the surface portion in 84 out of 110 samples with a median value of 0.53 μg/kg and in the inner core in 32 out of 110 samples with a median value lower than 0.1 μg/kg.     

Preparation and Characterization of Nanostructured TiO2/Epoxy Polymeric Films

Summary: Titania‐containing coatings were prepared by cationic photopolymerization of an epoxy resin either by dispersion of preformed TiO₂ nanoparticles or by their in‐situ generation through a sol‐gel dual‐cure process. The kinetics of photopolymerization was evaluated by real‐time FT‐IR, studying the effect of the TiO₂ concentration. The properties of cured films were investigated, showing an increase of hydrophilicity on the surface of the coatings with increasing TiO₂ content. TEM analysis demonstrated that it is possible to achieve a significantly better control of the dispersion of the inorganic particles within the organic matrix by in‐situ generation of TiO₂, thus completely avoiding macroscopic phase separation and obtaining homogeneous, transparent coatings.

Bright‐field TEM micrograph for TIP20 dual‐cured film.     

Efficient autonomic cloud computing using online discrete event simulation

Interest is growing in open source tools that let organizations build IaaS clouds using their own internal infrastructures, alone or in conjunction with external ones. A key component in such private/hybrid clouds is virtual infrastructure management, i.e., the dynamic orchestration of virtual machines, based on the understanding and prediction of performance at scale, with uncertain workloads and frequent node failures. Part of the research community is trying to solve this and other IaaS problems looking to Autonomic Computing techniques, that can provide, for example, better management of energy consumption, quality of service (QoS), and unpredictable system behaviors. In this context, we first recall the main features of the NAM framework devoted to the design of distributed autonomic systems. Then we illustrate the organization and policies of a NAM-based Workload Manager, focusing on one of its components, the Capacity Planner. We show that, when it is not possible to obtain optimal energy-aware plans analytically, sub-optimal plans can be autonomically obtained using online discrete event simulation. Specifically, the proposed approach allows to cope with a broader range of working conditions and types of workloads.     

Interferometric radar vs. accelerometer for dynamic monitoring of large structures: An experimental comparison

Interferometric radar has been recently proposed as a measurement instrument for dynamic testing/monitoring of large structures, such as bridges, towers, buildings, and dams, which is currently performed by networks of accelerometers. In this paper, the authors report a direct comparison between the two measurement techniques (radar interferometer vs. accelerometers) both employed during a field test on a bridge. As different quantities, displacement and acceleration are measured by the two techniques, a preliminary discussion about signals and noise has been necessary. Finally, the experimental results are critically discussed.     

3-carboxy-4-nitrophenyl-dithio-1,1′,2-trisnorsqualene: A site-directed inactivator of yeast oxidosqualene cyclase

The role and location of essential thiol groups in 2,3-oxidosqualene cyclase fromSaccharomyces cerevisiae was examined (i) by comparing inactivation properties of two known thiol reagents, 5,5′-dithiobis(2-nitrobenzoic acid) (DTNB) and 2-nitro-5-thiocyanobenzoic acid (NTCB), with 3-carboxy-4-nitrophenyl-dithio-1,1′,2-trisnorsqualene (CNDT-squalene), a new thiol reagent designed as a sitedirected inactivator of oxidosqualene cyclase and (ii) by testing the ability of the substrate to protect the enzyme against inactivation by the reagents. All reagents gave a time-dependent inactivation following pseudo-first order kinetics. DTNB and CNDT-squalene showed comparable inactivation ability (K_i=0.67 and 1.21 mM), whereas NTCB was less effective (K_i=15.6 mM). Strong differences between the two most active inhibitors, DTNB and CNDT-squalene, were observed when the enzyme was saturated with substrate prior to incubation with the thiol reagent. While substrate did not protect the enzyme against the inactivation caused by DTNB, a reduction in the inactivation ability of CNDT-squalene was observed under protection conditions. The data suggest that the squalene-like inactivator modifies a thiol group located at the active site of the enzyme.     

Effect of alloy element contents on caustic stress corrosion cracking of several stainless steels

The stress corrosion cracking behavior in caustic solutions (200 g/l sodium hydroxide, 10 g/l sodium chloride) of three austenitic (18Cr-10Ni-2.5Mo, 20Cr-25Ni-4.5Mo, 27Cr-31Ni-3.5Mo) and three duplex (23Cr-4Ni, 22Cr-5Ni-3Mo, 25Cr-7Ni-4Mo-N) stainless steels was examined. U-bend and Slow Strain Rate (SSR) tests were performed at 200–250°C. The negative influence of nickel in the lower range content for the 18Cr-10Ni-2.5Mo and 20Cr-25Ni-4.5Mo has been shown; when the nickel content is significantly increased (>30%), as in the case of the steel 27Cr-31Ni-3.5Mo, an increase of SCC resistance has been detected. The negative effect of molybdenum, mainly on the behaviour of duplex stainless steels, has also been evidenced. The duplex stainless steels show better caustic SCC resistance than austenitic stainless steels type 18Cr-10Ni-2.5Mo and 20Cr-25Ni-4.5Mo. The best behaviour has been found for the less-alloyed steel 23Cr-4Ni.     

A procedure to optimize the timing of operator actions of accident management procedures

The analysis of beyond design basis accidents (BDBA) is an essential component of the safety concept of nuclear power plants (NPP). Goal of the analysis is to achieve a set of actions aimed to prevent the escalation into a severe accident, to mitigate consequences of a severe accident, and to achieve a long term controllable state of the NPP. This paper presents an analytical procedure to optimize the timing of operator interventions. The procedure is demonstrated based on four sets of parameters, first, parameters which define the operator actions are chosen. Second, parameters which define the system availability are chosen. Third, parameters which define in a continuous way the status of the plant are chosen. Finally, one looks for a functional dependency of the accident management (AM)-parameters and the parameters describing the plant status. Once a function could be found, this function is “optimized” in the sense that the AM-parameters are varied to find a optimal overall condition for the plant. In the first part, the paper presents the analytical procedure in a general way, in the second part, an initiating event is chosen. The procedure is applied to a station black out (SBO) transient, and as operator action secondary side bleed and feed, followed by primary side bleed and feed, is foreseen. As result, the optimal timing to initiate both actions is achieved.     

Folate Functionalized Boron Nitride Nanotubes and their Selective Uptake by Glioblastoma Multiforme Cells: Implications for their Use as Boron Carriers in Clinical Boron Neutron Capture Therapy

Boron neutron capture therapy (BNCT) is increasingly being used in the treatment of several aggressive cancers, including cerebral glioblastoma multiforme. The main requirement for this therapy is selective targeting of tumor cells by sufficient quantities of ¹⁰B atoms required for their capture/irradiation with low-energy thermal neutrons. The low content of boron targeting species in glioblastoma multiforme accounts for the difficulty in selective targeting of this very malignant cerebral tumor by this radiation modality. In the present study, we have used for the first time boron nitride nanotubes as carriers of boron atoms to overcome this problem and enhance the selective targeting and ablative efficacy of BNCT for these tumors. Following their dispersion in aqueous solution by noncovalent coating with biocompatible poly-l-lysine solutions, boron nitride nanotubes were functionalized with a fluorescent probe (quantum dots) to enable their tracking and with folic acid as selective tumor targeting ligand. Initial in vitro studies have confirmed substantive and selective uptake of these nanovectors by glioblastoma multiforme cells, an observation which confirms their potential clinical application for BNCT therapy for these malignant cerebral tumors.