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51.
Giorgos Patrianakos Margaritis KostoglouAthanasios Konstandopoulos 《International Journal of Hydrogen Energy》2011,36(1):189-202
The solar thermal decomposition of methane is a promising route for the large scale production of hydrogen and carbon black with zero CO2 emissions, however careful control of the reactor is required to ensure product particles of specific sizes. A one-dimensional model employing a sectional method is developed to simulate the evolution of polydisperse fresh and seed particle populations in an indirectly heated solar reactor. The model accounts for the homogeneous nucleation of fresh particles, the heterogeneous growth of the fresh and seed particles, particle coagulation, and the growth of carbon on the walls of the reactor from heterogeneous reaction and particle deposition. The heat transport mechanisms modelled include wall-gas convection, wall-particle radiation exchange, particle-gas convection and heat release from chemical reaction. The model is validated in terms of methane conversion against a 10 kW experimental solar reactor and used to extract kinetic parameters for the homogeneous and heterogeneous reaction paths. The model shows promise as a quick and simple tool for the design and control of industrial scale solar reactors. 相似文献
52.
Tobias Berka Giorgos Kollias Helge Hagenauer Marian Vajteršic Ananth Grama 《The Journal of supercomputing》2013,63(2):385-406
Concurrency and parallelism have long been viewed as important, but somewhat distinct concepts. While concurrency is extensively used to amortize latency (for example, in web- and database-servers, user interfaces, etc.), parallelism is traditionally used to enhance performance through execution on multiple functional units. Motivated by an evolving application mix and trends in hardware architecture, there has been a push toward integrating traditional programming models for concurrency and parallelism. Use of conventional threads APIs (POSIX, OpenMP) with messaging libraries (MPI), however, leads to significant programmability concerns, owing primarily to their disparate programming models. In this paper, we describe a novel API and associated runtime for concurrent programming, called MPI Threads (MPIT), which provides a portable and reliable abstraction of low-level threading facilities. We describe various design decisions in MPIT, their underlying motivation, and associated semantics. We provide performance measurements for our prototype implementation to quantify overheads associated with various operations. Finally, we discuss two real-world use cases: an asynchronous message queue and a parallel information retrieval system. We demonstrate that MPIT provides a versatile, low overhead programming model that can be leveraged to program large parallel ensembles. 相似文献
53.
In this paper, we introduce an efficient mechanism to collect, store, and retrieve data provenance information in workflows of multiphysics simulations. Using notifications, we enable the nonintrusive collection of information about workflow events during workflow execution. Combining these events with workflow structure information, constant for every execution of a workflow, we obtain the data provenance information for the specific run of the workflow. Data provenance information is structured into a graph that represents workflow events on the basis of their causal dependency. We use a graph database to store this graph and utilize the traversal framework provided, to efficiently retrieve data provenance information from the graph by traversing backwards from a data object to every workflow event that is part of its provenance. Finally, we integrate data provenance information with semantics of workflow services to provide complete and meaningful data provenance information. Copyright © 2012 John Wiley & Sons, Ltd. 相似文献
54.
The organization of talent in online communities has been pivotal for the development of open source software. We are currently witnessing a related phenomenon that is at least of equal importance: the ‘open-sourcing’ of digital content through a dramatic increase in user-generated content and the development of appropriate licenses for users to share their works and build on each other's creativity. This article compares and contrasts (a) the objectives of software development vis-à-vis the development of new media content, (b) the organizational forms that have developed in respective online communities, and (c) the role that licensing plays in the production of ‘functional’ vis-à-vis ‘cultural’ goods. 相似文献
55.
Maria Tampakaki Mariam-Eleni Oraiopoulou Eleftheria Tzamali Giorgos Tzedakis Takis Makatounakis Giannis Zacharakis Joseph Papamatheakis Vangelis Sakkalis 《International journal of molecular sciences》2021,22(12)
Glioblastoma is the most malignant brain tumor among adults. Despite multimodality treatment, it remains incurable, mainly because of its extensive heterogeneity and infiltration in the brain parenchyma. Recent evidence indicates dysregulation of the expression of the Promyelocytic Leukemia Protein (PML) in primary Glioblastoma samples. PML is implicated in various ways in cancer biology. In the brain, PML participates in the physiological migration of the neural progenitor cells, which have been hypothesized to serve as the cell of origin of Glioblastoma. The role of PML in Glioblastoma progression has recently gained attention due to its controversial effects in overall Glioblastoma evolution. In this work, we studied the role of PML in Glioblastoma pathophysiology using the U87MG cell line. We genetically modified the cells to conditionally overexpress the PML isoform IV and we focused on its dual role in tumor growth and invasive capacity. Furthermore, we targeted a PML action mediator, the Enhancer of Zeste Homolog 2 (EZH2), via the inhibitory drug DZNeP. We present a combined in vitro–in silico approach, that utilizes both 2D and 3D cultures and cancer-predictive computational algorithms, in order to differentiate and interpret the observed biological results. Our overall findings indicate that PML regulates growth and invasion through distinct cellular mechanisms. In particular, PML overexpression suppresses cell proliferation, while it maintains the invasive capacity of the U87MG Glioblastoma cells and, upon inhibition of the PML-EZH2 pathway, the invasion is drastically eliminated. Our in silico simulations suggest that the underlying mechanism of PML-driven Glioblastoma physiology regulates invasion by differential modulation of the cell-to-cell adhesive and diffusive capacity of the cells. Elucidating further the role of PML in Glioblastoma biology could set PML as a potential molecular biomarker of the tumor progression and its mediated pathway as a therapeutic target, aiming at inhibiting cell growth and potentially clonal evolution regarding their proliferative and/or invasive phenotype within the heterogeneous tumor mass. 相似文献
56.
Giorgos Patrianakos Margaritis Kostoglou Athanasios G. Konstandopoulos 《International Journal of Hydrogen Energy》2012
Solar methane decomposition reactors are a novel technology for the production of carbon neutral hydrogen; however, the impact of this technology depends greatly on the ability to co-produce carbon black particles of commercial grade in order to offset the cost of hydrogen production and, therefore, the control of the reactor is very important. To this end, the seeding of indirect heating concept reactors using the product particles themselves could be used to control heat transfer inside the reactor. In this work, a previously developed one-dimensional reactor – particle population model was used to simulate the effect of seeding on the hydrogen and carbon particle production rates in the absorber tubes of a 10 MW indirect heating concept solar reactor. It was found that seed particle feed rates less than 10% of the methane-contained carbon feed rate allowed the hydrogen and fresh particle production rates to be doubled while keeping the rate of carbon growth on the tube walls constant. It was also found that similar seed fee rates could be used to maintain the hydrogen and particle production rates constant, given variations in the absorber tube wall temperature within a 100 °C range, for example due to cloud passage. Furthermore, it was found that the size characteristics of the freshly produced particles were not affected at these seed feed rates. Thus, seeding could be an effective means for increasing and controlling the hydrogen and carbon particle production rates in industrial scale indirect heating concept solar methane decomposition reactors, while also reducing carbon growth on the walls of the absorber tubes. 相似文献
57.
58.
Christos Chrysoulas Evangelos Haleplidis Giorgos Kostopoulos Robert Haas Odysseas Koufopavlou 《International Journal of Network Management》2008,18(4):345-363
Owing to the increase in both heterogeneity and complexity in today's networking systems, the need arises for new network‐based services architectures. They must provide flexibility and efficiency in the definition, deployment and execution of the services and, at the same time, handle the adaptability and evolution of such services. In this paper we present an approach that applies a Web‐service‐based resource management framework. It enables the provision of parallel applications as QoS‐aware applications, whose performance characteristics may be dynamically negotiated between a client application and service providers. Our component model allows context dependencies to be explicitly expressed and dynamically managed with respect to the hosting environment, computational resources and dependencies on other components. In such a model the resource management, in terms of representation, allocation and management of the resources, plays a vital role regarding the efficiency of the entire dynamic service deployment architecture. Copyright © 2007 John Wiley & Sons, Ltd. 相似文献
59.
Chaniotakis NA Alifragis Y Konstantinidis G Georgakilas A 《Analytical chemistry》2004,76(18):5552-5556
The gallium nitride (GaN) semiconductor is used as the sensing element for the development of a potentiometric anion sensor. The anion recognition mechanism is based on the selective interaction of anions in solution with the epitaxial Ga-face polarity GaN (0001) wurtzite crystal film grown on sapphire. The native GaN crystal is used for the development of an ion blocked sensor. The potential is based on the Volta potential, generated at the semiconductor/solution interface and within the Helmholtz layer, due to specifically adsorbed anions. The selectivity of the sensor is based on the direct interaction of the anionic ligand with the outer electron-defective gallium atoms; thus, it is not dependent on the lipophilicity of the adsorbed charged species. The chemical resistivity of the GaN crystal provides sensors with excellent lifetime, signal stability, and reproducibility. 相似文献
60.
For investigation of electron transport on the nanoscale, a system possessing a simple-to-interpret electronic structure is composed of alkane chains bridging two electrodes via end groups; to date, the majority of experiments and theoretical investigations on such structures have considered thiols bonding to gold electrodes. Recently experiments show that well-defined molecular conductances may be resolved if the thiol end groups are replaced by amines. In this theoretical study, we investigate the bonding of amine groups to gold clusters and calculate electron transport across the resulting tunnel junctions. We find very good agreement with recent experiments for alkane diamines and discuss differences with respect to the alkane dithiol system. 相似文献