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21.
The publish/subscribe model offers a loosely-coupled communication paradigm where applications interact indirectly and asynchronously. Publishers generate events that are sent to interested applications through a network of brokers. Subscribers express their interest by specifying filters that brokers can use for routing the events. Supporting confidentiality of messages being exchanged is still challenging. First of all, it is desirable that any scheme used for protecting the confidentiality of both the events and filters should not require publishers and subscribers to share secret keys. In fact, such a restriction is against the loose-coupling of the model. Moreover, such a scheme should not restrict the expressiveness of filters and should allow the broker to perform event filtering to route the events to the interested parties. Existing solutions do not fully address these issues. In this paper, we provide a novel scheme that supports (i) confidentiality for events and filters; (ii) allows publishers to express further constraints about who can access their events; (iii) filters that can express very complex constraints on events even if brokers are not able to access any information in clear on both events and filters; (iv) and, finally, it does not require publishers and subscribers to share keys. Furthermore, we show how we applied our scheme to a real-world e-health scenario, developed together with a hospital. We also describe the implementation of our solution in Java and the integration with an existing publish/subscribe system. 相似文献
22.
Francesca Truzzi Camilla Tibaldi Anne Whittaker Silvia Dilloo Enzo Spisni Giovanni Dinelli 《International journal of molecular sciences》2021,22(1)
There is a need to assess the relationship between improved rheological properties and the immunogenic potential of wheat proteins. The present study aimed to investigate the in vitro effects of total protein extracts from three modern and two landrace Triticum aestivum commercial flour mixes, with significant differences in gluten strength (GS), on cell lines. Cytotoxicity and innate immune responses induced by wheat proteins were investigated using Caco-2 monocultures, two dimensional (2D) Caco-2/U937 co-cultures, and three dimensional (3D) co-cultures simulating the intestinal mucosa with Caco-2 epithelial cells situated above an extra-cellular matrix containing U937 monocytes and L929 fibroblasts. Modern wheat proteins, with increased GS, significantly reduced Caco-2 cell proliferation and vitality in monoculture and 2D co-cultures than landrace proteins. Modern wheat proteins also augmented Caco-2 monolayer disruption and tight junction protein, occludin, redistribution in 3D co-cultures. Release of interleukin-8 into the cell medium and increased U937 monocyte migration in both 2D and 3D co-cultures were similarly apparent. Immuno-activation of migrating U937 cells was evidenced from cluster of differentiation 14 (CD14) staining and CD11b-related differentiation into macrophages. The modern wheat proteins, with gluten polymorphism relatedness and increased GS, were shown to be more cytotoxic and immunogenic than the landrace wheat proteins. 相似文献
23.
Prof. Alessia Carocci Dr. Mariagrazia Roselli Prof. Roberta Budriesi Dr. Matteo Micucci Prof. Jean-François Desaphy Dr. Concetta Altamura Dr. Maria Maddalena Cavalluzzi Dr. Maddalena Toma Dr. Giovanna Ilaria Passeri Dr. Gualtiero Milani Dr. Angelo Lovece Prof. Alessia Catalano Dr. Claudio Bruno Dr. Annalisa De Palma Prof. Filomena Corbo Prof. Carlo Franchini Prof. Solomon Habtemariam Prof. Giovanni Lentini 《ChemMedChem》2021,16(3):578-588
Under the hypothesis that cardioprotective agents might benefit from synergism between antiarrhythmic activity and antioxidant properties, a small series of mexiletine analogues were coupled with the 2,2,5,5-tetramethylpyrroline moiety, known for its antioxidant effect, in order to obtain dual-acting drugs potentially useful in the protection of the heart against post-ischemic reperfusion injury. The pyrroline derivatives reported herein were found to be more potent as antiarrhythmic agents than mexiletine and displayed antioxidant activity. The most interesting tetramethylpyrroline congener, a tert-butyl-substituted analogue, was at least 100 times more active as an antiarrhythmic than mexiletine. 相似文献
24.
Martina Mazzariol Giovanni Camussi Maria Felice Brizzi 《International journal of molecular sciences》2021,22(8)
Extracellular vesicles (EV) are microparticles released in biological fluids by different cell types, both in physiological and pathological conditions. Owing to their ability to carry and transfer biomolecules, EV are mediators of cell-to-cell communication and are involved in the pathogenesis of several diseases. The ability of EV to modulate the immune system, the coagulation cascade, the angiogenetic process, and to drive endothelial dysfunction plays a crucial role in the pathophysiology of both autoimmune and renal diseases. Recent studies have demonstrated the involvement of EV in the control of renal homeostasis by acting as intercellular signaling molecules, mediators of inflammation and tissue regeneration. Moreover, circulating EV and urinary EV secreted by renal cells have been investigated as potential early biomarkers of renal injury. In the present review, we discuss the recent findings on the involvement of EV in autoimmunity and in renal intercellular communication. We focused on EV-mediated interaction between the immune system and the kidney in autoimmune diseases displaying common renal damage, such as antiphospholipid syndrome, systemic lupus erythematosus, thrombotic microangiopathy, and vasculitis. Although further studies are needed to extend our knowledge on EV in renal pathology, a deeper investigation of the impact of EV in kidney autoimmune diseases may also provide insight into renal biological processes. Furthermore, EV may represent promising biomarkers of renal diseases with potential future applications as diagnostic and therapeutic tools. 相似文献
25.
Fernando Corvillo Laura Gonzlez-Snchez Alberto Lpez-Lera Emilia Arjona Giovanni Ceccarini Ferruccio Santini David Araújo-Vilar Rebecca J Brown Joan Villarroya Francesc Villarroya Santiago Rodríguez de Crdoba Teresa Caballero Pilar Nozal Margarita Lpez-Trascasa 《International journal of molecular sciences》2021,22(12)
26.
27.
The report presents an innovative solar barometric distillation technology for seawater desalting (SW-SBD) which has several attractive features such as: (1) efficient vacuum solar collectors of simple construction; (2) a barometric layout for quasi-steady operation at subatmospheric pressure; (3) a demister system of simple mechanical construction; and (4) an electronic control system regulating plant productivity parameters on available solar radiation flux. The proposed seawater desalting technology consists of single-effect distillation with water vapor produced and heated at subatmospheric pressure in a solar collector loop; the basic layout, operational features, and energy efficiency are presented and analysed in detail. Subsequent reports will provide technico-economical data from prototype desalting plants in view of industrial implementation. A promising specific electric energy consumption,∼2 kWm3 offresh water produced, was found by estimating pumping power requirements of major SW-SBD plant pumps. A sizable reduction in produced water cost with respect to an existing solar seawater desalting plant in Abu Dhabi is expected on the basis of a preliminary economic evaluation for a ∼100 m3/d plant prototype. 相似文献
28.
Francesca Guidi Giovanni Carta Gilberto Rossetto Guido Salmaso 《Electrochimica acta》2005,50(23):4609-4614
Alumina (Al2O3) coatings of different thickness were deposited on OT59 brass substrate (BS) using the metal organic chemical vapour deposition (MOCVD) technique to evaluate the corrosion performance by EIS measurements. The used precursor was dimethyl-aluminium-isopropoxide. Electrochemical characterizations of the deposited films were performed in a standard very aggressive acidic solution (aerated 1N H2SO4 at 25 °C up to 168 h of immersion time) by means of direct current method (Tafel curves) and electrochemical impedance spectroscopy (EIS). The Rutherford backscattering spectroscopy (RBS) indicated that the films are very pure with the correct Al2O3 stoichiometry, while the IR absorption spectra showed that the films did not contain any OH groups. The surface film morphology was investigated by atomic force microscopy (AFM) and displayed a globular texture. The films were very smooth, with a maximum root mean square roughness, for example, of 14 nm for a 0.96 μm thick coating. The EIS data confirmed, as expected, that a 2.40 μm Al2O3 layer ensures the best corrosion protection after 168 h of immersion in the very acidic environment used. 相似文献
29.
Giuseppe Ajroldi Maurizio Pianca Massimiliano Fumagalli Giovanni Moggi 《Polymer》1989,30(12):2180-2187
The dynamic-mechanical properties of some fluoroelastomers were determined as a function of composition at low frequency (≈ 1 Hz), by means of a free oscillation torsion pendulum, between −180°C and the softening point. Vinylidenefluoride (VDF)-hexafluoropropene (HFP) copolymers of molar composition 0–39% HFP and terpolymers of VDF and HFP with up to 30mol% tetrafluoroethylene (TFE) and a constant VDF to HFP molar ratio of 3.4 were considered. Two relaxation processes typical of the amorphous phase were found. The first, located at about −87°C, is related to local motions and the transition temperature was found to be independent of composition for copolymers, while it depends on TFE molar content for terpolymers. The second is related to the glass transition and the transition temperature depends on the composition. However, for semicrystalline copolymers the double glass transition phenomenon was observed. When crystallinity goes to zero at about 20 mol% HFP, only one transition is observed. It was also found that ordered structures can take place for terpolymers when TFE molar concentration exceeds 20%. The crystal disorder transition of pure PVDF (75°C) is observed also for low HFP concentrations but the transition temperature is strongly reduced. Analogies between the VDF-HFP and E-P systems are also discussed. 相似文献
30.