Speed control of induction motors using a novel fuzzy sliding-modestructure

This paper presents a new approach to indirect vector control of induction motors. Two nonlinear controllers, one of sliding mode type and the other PI-fuzzy logic-based, define a new control structure. Both controllers are combined by means of an expert system based on Takagi-Sugeno fuzzy reasoning. The sliding-mode controller acts mainly in a transient state while the PI-like fuzzy controller acts in the steady state. The new structure embodies the advantages that both nonlinear controllers offer: sliding-mode controllers increasing system stability limits, and PI-like fuzzy logic based controllers reducing the chattering in permanent state. The scheme has been implemented and experimentally validated     

Optimal digital filtering for tremor suppression

Remote manually operated tasks such as those found in teleoperation, virtual reality, or joystick-based computer access, require the generation of an intermediate electrical signal which is transmitted to the controlled subsystem (robot arm, virtual environment, or a cursor in a computer screen). When human movements are distorted, for instance, by tremor, performance can be improved by digitally filtering the intermediate signal before it reaches the controlled device. This paper introduces a novel tremor filtering framework in which digital equalizers are optimally designed through pursuit tracking task experiments. Due to inherent properties of the man-machine system, the design of tremor suppression equalizers presents two serious problems: 1) performance criteria leading to optimizations that minimize mean-squared error are not efficient for tremor elimination and 2) movement signals show ill-conditioned autocorrelation matrices, which often result in useless or unstable solutions. To address these problems, a new performance indicator in the context of tremor is introduced, and the optimal equalizer according to this new criterion is developed. Ill-conditioning of the autocorrelation matrix is overcome using a novel method which we call pulled-optimization. Experiments performed with artificially induced vibrations and a subject with Parkinson's disease show significant improvement in performance. Additional results, along with MATLAB source code of the algorithms, and a customizable demo for PC joysticks, are available on the Internet at http:?tremor-suppression.com.     

Sol-gel preparation and thermal stability of Pd/γ-Al2O3 catalysts

A series of Pd/-Al₂O₃ catalysts with a designed loading of 1 wt % were prepared by the sol-gel method using boehmite (AlOOH) sols and various palladium compounds. These materials were developed for later use as inorganic membranes. The samples were calcined at 400 °C in flowing O₂ to decompose the Pd complex and change the phase of the support to -Al₂O₃. H₂ pulse chemisorption was used to determine the average Pd particle sizes, while particle size distributions were obtained from TEM micrographs. XRD was used to determine the crystallinity of the -Al₂O₃ support after extended treatments at 650 °C in O₂ and H₂ atmospheres. The physical properties of the support were studied using nitrogen adsorption-desorption at 77 K. Initial BET surface areas were about 350 m²/g. Pore size distributions were very narrow and centered at 3.6 nm, but broadened and became bimodal during the 650 °C treatments. An ion-exchanged sample prepared by traditional methods was used as a basis for comparison to the sol-gel samples.     

Congenital abnormalities in Brazilian children associated with misoprostol misuse in first trimester of pregnancy

BACKGROUND: Misoprostol is commonly used to induce abortion in Brazil, and in other countries in South and Central America where abortions are illegal. However, misoprostol is not very effective in inducing abortions, and exposure to the drug in utero can cause abnormalities in the fetus. We aimed to define the common phenotypical effects of exposure to the drug. METHODS: We studied 42 infants from S?o Paulo, Brazil, who were exposed to misoprostol during the first 3 months of gestation, and then born with congenital abnormalities. We interviewed each of the infants' mothers to find out about misoprostol exposure and dosage. Each infant was physically examined by a geneticist or a neuropaediatrician. FINDINGS: 17 of the infants had equinovarus with cranial-nerve defects. Ten children had equinovarus as part of more extensive arthrogryposis. The most distinctive phenotypes were arthrogryposis confined to the legs (five cases) and terminal transverse-limb defects (nine cases) with or without Mobius sequence. The most common dose of misoprostol taken was 800 microg (range 200-16000 microg). INTERPRETATION: Deformities attributed to vascular disruption were found in these children. We suggest that the uterine contractions induced by misoprostol cause vascular disruption in the fetus, including brain-stem ischaemia. Information on the effects of taking misoprostol during pregnancy should be made more widely available, to dissuade women from misusing the drug.     

Management of psychiatric symptoms in medically ill patients in the homecare setting

Nurses with critical care knowledge and experience increasingly provide technologically advanced care to patients at home who often present comorbid psychiatric symptoms. Failure to accurately recognize and provide appropriate intervention can be devastating for patients because these symptoms can exacerbate the medical condition and may lead to mortality. The Biopsychosocial Model and the Transactional Model of Stress were presented as guides for nursing practice. Practice is directed at 1) understanding the patient's perception of events, 2) involving the caregiver(s) in the patient's recovery, and 3) enhancing the individual's adaptive coping efforts and resources. The article attempts to guide nurses in making decisions on when to consult and collaborate with an APPN to achieve desired patient outcomes.     

Evaluation of atypical cytochrome P450 kinetics with two-substrate models: evidence that multiple substrates can simultaneously bind to cytochrome P450 active sites

Some cytochrome P450 catalyzed reactions show atypical kinetics, and these kinetic processes can be grouped into five categories: activation, autoactivation, partial inhibition, substrate inhibition, and biphasic saturation curves. A two-site model in which the enzyme can bind two substrate molecules simultaneously is presented which can be used to describe all of these observed kinetic properties. Sigmoidal kinetic characteristics were observed for carbamazepine metabolism by CYP3A4 and naphthalene metabolism by CYPs 2B6, 2C8, 2C9, and 3A5 as well as dapsone metabolism by CYP2C9. Naphthalene metabolism by CYP3A4 and naproxen metabolism by CYP2C9 demonstrated nonhyperbolic enzyme kinetics suggestive of a low Km, low Vmax component for the first substrate molecule and a high Km, high Vmax component for the second substrate molecule. 7, 8-Benzoflavone activation of phenanthrene metabolism by CYP3A4 and dapsone activation of flurbiprofen and naproxen metabolism by CYP2C9 were also observed. Furthermore, partial inhibition of 7, 8-benzoflavone metabolism by phenanthrene was observed. These results demonstrate that various P450 isoforms may exhibit atypical enzyme kinetics depending on the substrate(s) employed and that these results may be explained by a model which includes simultaneous binding of two substrate molecules in the active site.     

Crystal structures of a single coiled-coil peptide in two oligomeric states reveal the basis for structural polymorphism

Each protein sequence generally adopts a single native fold, but the sequence features that confer structural uniqueness are not well understood. To define the basis for structural heterogeneity, we determined the high resolution X-ray crystal structures of a single GCN4 leucine-zipper mutant (Asn 16 to aminobutyric acid) in both dimeric and trimeric coiled-coil conformations. The mutant sequence is accommodated in two distinct structures by forming similarly-shaped packing surfaces with different sets of atoms. The trimer structure, in comparison to a previously-characterized trimeric mutant with substitutions in eight core residues, shows that the twist of individual helices and the helix-helix crossing angles can vary significantly to produce the most favoured packing arrangement.     

Gestational meconium: a sign of poor neonatal prognosis

Seventy five pregnancies where the presence of antepartum meconium was detected by transabdominal amniocentesis, were compared with 224 cases showing clear amniotic fluid (A.F.). The statistical differences were analized in terms of data of anamnesis, diseases complicating pregnancy, gestational age, fetal maturity diagnosis from the A.F. study, oxytocin test, labor characteristics, perinatal mortality and neurologic morbidity during the first nine months of life. The results suggest that the presence of antepartum meconium implies an increase in fetal risk, demanding an adequate analysis of the obstetric solutions, which is discussed.     

Approaches to establishing reference levels in interventional radiology

Reference levels in radiodiagnostics are a requirement stated by the Council Directive 97/43/EURATOM. Reference levels are also relevant for interventional procedures, in accordance with this Directive, which claims special attention to quality assurance programmes, including quality control and patient dose evaluations for special practices such as interventional radiology, to assess the convenience of corrective action depending on the measured doses. The present paper addresses a method of establishing reference levels in interventional radiology, in the framework of optimisation, discussing the ways of putting forward values with a degree of tolerance, to allow for procedure complexity, depending on patient pathology. The need for several estimators used together, namely fluoroscopy time, total number of images per procedure and dose-area product, is also emphasised, proposing a further skin dose estimate in case of risk of deterministic effects. Finally, a brief summary of principles is given for the correct management of reference levels in interventional radiology.     

Considerations on the design of sectored receivers for wireless optical channels using a Monte-Carlo-based ray-tracing algorithm

A study of the design of a sectored receiver structure that offers improved performance with respect to the main infrared channel parameters, such as path loss and rms delay spread, is presented. To this end, a model for the effective signal collection area of a sectored receiver is presented and validated that, through the use of a Monte-Carlo-based ray-tracing algorithm, allows us to obtain the channel impulse response. The simulation results presented show the effect of the orientation and field of view (FOV) of each sector on the quality of the received signal. On the basis of these results, the use of a sectored receiver, composed of three crowns of sectors with different vertical and horizontal FOVs, has been proposed that minimizes the multipath dispersion and power requirements.