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11.
Alexander Babich Konstantinos Mavrommatis Dieter Senk Heinrich Wilhelm Gudenau 《国际钢铁研究》2004,75(7):428-432
This contribution deals with advanced educational technologies needed to equip customers from higher education institutions, research and industry with efficient tools supporting their work and operating new skills‐training methods. The challenges are reducing the training costs, improving quality and increasing the number of graduates in engineering departments. The concept of a Virtual Lab based on the combination of various teaching methods and tools is presented. Principles of mathematisation in metallurgical education and training are discussed. An example of online course designed in the form of Virtual Lab is demonstrated. 相似文献
12.
Previous studies have shown that mu (mu) and kappa (kappa) opioid antagonists inhibit suckling-induced prolactin release. Prolactin responses elicited by pup suckling or opioid administration are mediated, at least in part, by suppression of dopamine (DA) release from tuberoinfundibular dopaminergic (TIDA) neurons in the hypothalamus. We examined the effects of the mu opiate receptor antagonist, beta-funaltrexamine (beta-FNA), and the kappa opiate receptor antagonist, nor-binaltorphimine (nor-BNI) on the activity of TIDA neurons in lactating rats. TIDA neuronal activity was determined by measuring DOPA accumulation in the caudate putamen (CP) and median eminence (ME). The effects of opioid antagonist treatment were determined in pup-deprived (low circulating prolactin levels) or pup-suckled rats (high circulating prolactin levels). The accumulation of 5-hydroxytryptophan (5-HTP) in the medial preoptic area (MPOA), the anterior hypothalamus (AH) and the median eminence (ME) was quantified as an index of serotonergic activity in the same animals for comparative purposes. In vehicle treated rats, suckling caused a significant and selective decrease in DOPA accumulation in the ME. beta-FNA (5 micrograms, i.c.v.) pretreatment significantly increased DOPA accumulation in the ME of pup-deprived and pup-suckled rats. beta-FNA pretreatment also prevented the suckling-induced suppression of DOPA accumulation in the ME. In contrast to the actions of beta-FNA, pretreatment with nor-BNI (8 micrograms, i.c.v.) did not significantly affect the activity of the TIDA neurons in pup-deprived or pup-suckled rats. Suckling alone did not alter 5-HTP accumulation in any of the brain regions examined, and neither opioid antagonist had appreciable effects on 5-HTP accumulation. These results demonstrate that the EOP tonically inhibit the TIDA neurons in both pup-deprived and pup-suckled, post-partum female rats by acting through the mu, but not the kappa, opiate receptor subtype. Furthermore, the suckling-induced inhibition of TIDA neurons is also mediated through the EOP acting at mu, but not kappa opioid receptors. 相似文献
13.
Baumann Stephen B. Joines William T. Berman Ezra 《IEEE transactions on bio-medical engineering》1987,(9):754-757
Batteryless temperature transponders have been constructed and tested. The design employs a sensing element consisting of a miniature cavity resonator loaded with a ceramic material of high dielectric constant and large temperature coefficient of resonant frequency. This is connected by thin coaxial cable to a small dipole or sector antenna. Prototypes with sensors 3 mm in diameter have been fabricated and can resolve temperature differences of 0.1°C in air. Signals have been obtained from transponders implanted in anesthetized rats, but antenna orientation is a critical and limiting factor that will require further efforts before a system is capable of operating in freely roaming animals. 相似文献
14.
A three-phase three-switch buck-type pulsewidth modulation rectifier is designed for telecom applications in this paper. The rectifier features a constant 400-V output voltage and 5-kW output power at the three-phase 400-V mains. The principle of operation and the calculation of the relative on-times of the power transistors are described. Based on analytical relationships the stresses of the active and passive components are determined and the accuracy of the given calculations is verified by digital simulations. Exemplarily, a 5-kW power converter is then designed based on the analytical expressions and on switching loss measurements from a hardware prototype constructed with insulated gate bipolar transistor/diode power modules. The loss distribution of the components, the total efficiency, and the junction temperatures of the semiconductors are then evaluated in dependency on the operating point. Finally, the trade-off between the selected switching frequency and the admissible power range for the realized design is shown and a total efficiency of 95.0% is measured on the hardware prototype, where an excellent agreement with the theoretically evaluated efficiency is shown 相似文献
15.
H. Baumann 《European Journal of Lipid Science and Technology》1990,92(2):49-56
New Developments in the Field of Oleochemical Surfactants A large area of application for fats and oils in the technical field is the manufacture of surfactants. The oleochemical industry has long been making intensive efforts to gain a still greater share of the world's surfactant production for oleochemical surfactants. There are some promising conditions to reach this goal. New developments in the field of anionic and nonionic surfactants are summarized in an overview. There will be discussed fatty alcohol sulfates (especially tallow alcohol sulfate), α-sulfo-fatty acid methylesters, acyl cyanamides, non-terminal fatty acid methylester sulfonates (by sulfoxidation of saturated fatty acid methylesters and by SO3-sulfonation of unsaturated fatty acid esters), oleic acid sulfonates, alkyl- and alkenyl ether sulfonates, hydroxy alkyl ether sulfates, alkyl glucosides, fatty alcohol polyethyleneglycol alkyl ethers and -hydroxyalkyl ethers and narrow range fatty alcohol ethoxylates. The development work on new oleochemical surfactants which has been described permits the conclusion that in future oleochemical surfactants will further increase their share of world surfactant production. 相似文献
16.
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18.
W. Stein H. Weiß O. Koch P. Neuhausen H. Baumann 《European Journal of Lipid Science and Technology》1970,72(11):956-959
Preparation of Esters of α-Sulfo-Fatty Acids A process for the continuous α-sulfonation of saturated fatty acid esters with SO3 was worked out and a special bleaching process was developed for these products. The conversion, i. e. the degree of sulfonation is of the order of 95–99%. Solvents, further processing steps or purification operations for the separation of by-products are not required. 相似文献
19.
Summary This paper presents an investigation of the dependence of harmonic-like topological constraints in entangled and moderately crosslinked polymer networks on segment and crosslink density and on the deformation of the sample. The approach is an extension of a theory developed for the highly crosslinked case and for polymer melts. The results are used to discuss the influence of topological constraints on the mechanical properties of different types of rubberelastic networks. 相似文献
20.
M. P. Murari R. Murari S. Parthasarathy C. A. Guy V. V. Kumar B. Malewicz Wolfgang J. Baumann 《Lipids》1990,25(10):606-612
Described is a reaction sequence for the total synthesis of lyso platelet activating factor (lysoPAF; 1-O-alkyl-sn-glycero-3-phosphocholine) and its enantiomer. The procedure is versatile and yields optically pure isomers of defined chain
length. The synthesis is equally suited for the preparation of lysoPAF analogues and its enantiomers with unsaturation in
the long aliphatic chain. First,rac-1(3)-O-alkylglycerol is prepared by alkylation ofrac-isopropylideneglycerol with alkyl methanesulfonate followed by acid-catalyzed removal of the ketal group. The primary hydroxy
group of alkylglycerol is then protected by tritylation, the secondary hydroxy group is acylated, and the protective trityl
group is removed under mild acidic conditions with boric acid on silicic acid, essentially without acyl migration. Condensation
of the diradylglycerol with bromoethyl dichlorophosphate in diethyl ether, hydrolysis of the resulting chloride, and nucleophilic
displacement of the bromine with trimethylamine givesrac-1-O-alkyl-2-acylglycero-3-phosphocholine in good overall yield. The racemic alkylacylglycerophosphocholine is finally treated
with snake venom phospholipase A2 (Ophiophagus hannah) which affords 1-O-alkyl-sn-glycero-3-phosphocholine (lysoPAF) of natural configuration in optically pure form. The “unnatural” 3-O-alkyl-2-O-acyl-sn-glycerol-1-phosphocholine enantiomer, which is not susceptible to phospholipase A2 cleavage, gives 3-O-alkyl-sn-glycero-1-phosphocholine upon deacylation with methanolic sodium hydroxide. Homogeneity and structure of the intermediates
and final products were ascertained by carbon-13 nuclear magnetic resonance spectroscopy on monomeric solutions. 相似文献