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961.
    
For the cultivation of Dunaliella salina (a green unicellular eukaryote photosynthetic microalga), a 20 L indoor helical-tubular photobioreactor was designed. The inner diameter and the thickness of the PU (polyurethane) tube were 12 and 2 mm, respectively, and its length was 75 m. An open pond was located on the top of the PBR structure and a pump circulated the culture medium from the pond to the tubes. Another part of the tube was connected to an airlift column (which was connected to the bottom of the pond), and the culture medium completed its circulation by moving from the airlift column that connected the closed system (tubular) to the open system (open pond). Eight LED lamps with 10 000 lx were set around the tube and a 2000 lx LED was adjusted on the top of the pond. The culture salinity within the PBR was 1 mol L−1 and four intermittent steps of 0.5 mol L−1 salt stresses were injected into the culture medium. The highest beta-carotene production within this hybrid helical-tubular PBR was 4.85 µg of beta-carotene per mg of dry weight of microalgae at 2.5 mol L−1 salinity.  相似文献   
962.
    
In this study, the effects of the type and content of reactive diluents on the permeation/separation of carbon dioxide/nitrogen (CO2/N2) through acrylate-terminated polyurethane (APU)-acrylate/acrylic diluent (APUA) composite membranes was investigated. A series of APUs based on poly(ethylene glycol) (PEG)-1000 g mol−1, toluene diisocyanate, and 2-hydroxyethyl methacrylate was synthesized and then diluted with several reactive diluents. The results obtained from differential scanning calorimetry (DSC) and Fourier transform infrared analyses showed that the microphase interference of hard and soft segments increased with increasing reactive diluent content. Furthermore, with increasing alkene double bond of reactive diluents, the degree of phase separation increased, which might be due to the higher gel content of APUAs. APUAs were used as top selective layer on PS/PSF as the support layer to obtain composite membrane. Field emission scanning electron microscopy micrographs revealed that APUAs penetrated into the support layer, leading to strong interfacial adhesion between APUA and support layers. The gas permeation experiments indicated that the gas permeability decreased, while the CO2/N2 selectivity increased with increasing reactive diluent content due to the enhancement of crosslinking density of APUAs. Moreover, the reactive diluent with high polarity, for example, acrylonitrile monomer, exhibited higher CO2/N2 selectivity due to the improvement in solubility of CO2 in APUA, while the permeability was retained compared with other reactive diluents. The thickness of APUA selective layer exhibited expectedly opposite effect on permeability and selectivity; however, the increment in selectivity is higher than the reduction in permeability when the thickness decreased from 50 to 10 μm. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020 , 137, 48293.  相似文献   
963.
    
Geo-energy and geo-engineering applications,such as improved oil recovery(IOR),geologic carbon storage,and enhanced geothermal systems(EGSs),involve coupled thermo-hydro-mechanical(THM)processes that result from fluid injection and production.In some cases,reservoirs are highly fractured and the geomechanical response is controlled by fractures.Therefore,fractures should explicitly be included into numerical models to realistically simulate the THM responses of the subsurface.In this study,we perform coupled THM numerical simulations of water injection into naturally fractured reservoirs(NFRs) using CODE_BRIGHT and TOUGH-UDEC codes.CODE_BRIGHT is a finite element method(FEM) code that performs fully coupled THM analysis in geological media and TOUGH-UDEC sequentially solves coupled THM processes by combining a finite volume method(FVM) code that solves nonisothermal multiphase flow(TOUGH2) with a distinct element method(DEM) code that solves the mechanical problem(UDEC).First,we validate the two codes against a semi-analytical solution for water injection into a single deformable fracture considering variable permeability based on the cubic law.Then,we compare simulation results of the two codes in an idealized conceptual model that includes one horizontal fracture and in a more realistic model with multiple fractures.Each code models fractures differently.UDEC calculates fracture deformation from the fracture normal and shear stiffnesses,while CODE_BRIGHT treats fractures as equivalent porous media and uses the equivalent Young's modulus and Poisson's ratio of the fracture.Finally,we obtain comparable results of pressure,temperature,stress and displacement distributions and evolutions for the single horizontal fracture model.Despite some similarities,the two codes provide increasingly different results as model complexity increases.These differences highlight the challe nging task of accurately modeling coupled THM processes in fractured media given their high nonlinearity.  相似文献   
964.
965.
966.
    
Superparamagnetic iron oxide nanoparticles (SPIONs) conjugated with anti‐epidermal growth factor receptor monoclonal antibody (anti‐EGFR‐SPIONs) were characterised, and its cytotoxicity effects, ex vivo and in vivo studies on Lewis lung carcinoma (LLC1) cells in C57BL/6 mice were investigated. The broadband at 679.96 cm−1 relates to Fe–O, which verified the formation of the anti‐EGFR‐Mab with SPIONs was obtained by the FTIR. The TEM images showed spherical shape 20 and 80 nm‐sized for nanoparticles and the anti‐EGFR‐SPIONs, respectively. Results of cell viability at 24 h after incubation with different concentrations of nanoprobe showed it has only a 20% reduction in cell viabilities. The synthesised nanoprobe administered by systemic injection into C57BL/6 mice showed good Fe tumour uptake and satisfied image signal intensity under ex vivo and in vivo conditions. A higher concentration of nanoprobe was achieved compared to non‐specific and control, indicating selective delivery of nanoprobe to the tumour. It is concluded that the anti‐EGFR‐SPIONs was found to be as an MR imaging contrast nanoagent for lung cancer (LLC1) cells detection.Inspec keywords: toxicology, biomedical MRI, lung, magnetic particles, biomedical materials, nanofabrication, nanomagnetics, transmission electron microscopy, nanomedicine, superparamagnetism, nanoparticles, iron compounds, proteins, cellular biophysics, molecular biophysics, cancer, tumours, Fourier transform infrared spectraOther keywords: MR imaging contrast agent, LLC1, superparamagnetic iron oxide nanoparticles, Lewis lung carcinoma cells, ex vivo conditions, cell viability, antiepidermal growth factor receptor antibody‐based iron oxide nanoparticles, antiEGFR‐SPION, lung cancer cell detection, antiepidermal growth factor receptor monoclonal antibody, cytotoxicity effects, C57BL‐6 mice, antiEGFR‐Mab, FTIR spectra, TEM, spherical shape, incubation, nanoprobe concentrations, systemic injection, Fe tumour uptake, image signal intensity, in vivo conditions, time 24.0 hour, Fe3 O4   相似文献   
967.
    
Next generation engineered tissue constructs with complex and ordered architectures aim to better mimic the native tissue structures, largely due to advances in 3D bioprinting techniques. Extrusion bioprinting has drawn tremendous attention due to its widespread availability, cost‐effectiveness, simplicity, and its facile and rapid processing. However, poor printing resolution and low speed have limited its fidelity and clinical implementation. To circumvent the downsides associated with extrusion printing, microfluidic technologies are increasingly being implemented in 3D bioprinting for engineering living constructs. These technologies enable biofabrication of heterogeneous biomimetic structures made of different types of cells, biomaterials, and biomolecules. Microfluiding bioprinting technology enables highly controlled fabrication of 3D constructs in high resolutions and it has been shown to be useful for building tubular structures and vascularized constructs, which may promote the survival and integration of implanted engineered tissues. Although this field is currently in its early development and the number of bioprinted implants is limited, it is envisioned that it will have a major impact on the production of customized clinical‐grade tissue constructs. Further studies are, however, needed to fully demonstrate the effectiveness of the technology in the lab and its translation to the clinic.  相似文献   
968.
    
In this paper, a new class of two‐dimensional nonlinear variable‐order fractional optimal control problems (V‐OFOCPs) is introduced where the variable‐order fractional derivative is defined in the Caputo type. The general procedure for solving theses systems is expanding the state variable and the control variable based on the Legendre cardinal functions in the matrix form. Hence, we derive their operational matrix of derivative (OMD) and operational matrix of variable‐order fractional derivative (OMV‐OFD). More significantly, some properties of these basis functions are proved to be exploited in our approach. Using these achieved results, we simply expand the matrix form of the nonlinear performance index in terms of the Legendre cardinal functions and subsequently convert it to an algebraic equation. We emphasize that it is a valuable advantage of applying cardinal functions in approximation theory. Then, we implement the OMD and the OMV‐OFD of the Legendre cardinal functions to transform the variable‐order fractional dynamical system to a system of algebraic equations. Next, the method of constrained extremum is applied to adjoin the constraint equations including the given dynamical system and the initial‐boundary conditions to the performance index by a set of undetermined Lagrange multipliers. Finally, the necessary conditions of the optimality are derived as a system of nonlinear algebraic equations including the unknown coefficients of the state variable, the control variable and the Lagrange multipliers. The applicability and efficiency of the proposed approach are investigated through the various types of test problems.  相似文献   
969.
    
ABSTRACT

The explosion (detonation) temperature of organic compounds containing energetic groups can be related to the study of the kinetics of chemical reactions in the reaction zone as well as the thermodynamic state of the detonation products. It can be predicted by a simple approach for ideal and less ideal energetic compounds as well as non-ideal composite explosives containing aluminum (Al) or ammonium nitrate (AN). A general correlation is introduced for calculation of the explosion temperature from the heat of detonation where it can be corrected for AN and liquid organic energetic compounds. For ideal and less ideal energetic compounds, the predicted results are compared with the outputs of complex thermochemical/hydrodynamic computer codes using two appropriate equations of state (BKWR-EOS and BKWS-EOS). The values of mean absolute percentage error (MAPE) in the explosion temperature for ideal and less ideal organic energetic compounds are 5.4, 5.5 and 12.5 for the new method, BKWS-EOS, and BKWR-EOS, respectively. The new method shows good agreement for non-ideal energetic compounds with respect to the outputs of BKWS-EOS using partial equilibrium where it provides good predictions for detonation performance.  相似文献   
970.
    
Wholemeal bread is strongly recommended due to its nutritional value. However, whole‐grain foods contain a high level of phytic acid, an antinutritional factor that decreases the mineral bioavailability. The objective of this study was isolation and identification of lactic acid bacteria with phytase activity to find a suitable starter for bread‐making. Wheat–legume sourdoughs were prepared by the back‐slopping procedure. Lactic acid bacteria were isolated from the sourdough of wheat flour–mung bean, and their phytase activity was tested in the solid and liquid media. Out of the nine phytase‐active isolates in the solid medium, only three isolates produced extracellular phytase in the liquid medium with activity ranging from 16.3 to 53.2 (U/ml). These isolates belonged to species Weissella confusa mk.zh95 and Pediococcus pentosaceus. The highest phytase activity was found for Weissella confusa mk.zh95. Weissella confusa mk.zh95 is considered an interesting source of phytase during cereals and legumes fermentation which improves the bioavailability of minerals.  相似文献   
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