Robust regression for high throughput drug screening

Effective analysis of high throughput screening (HTS) data requires automation of dose-response curve fitting for large numbers of datasets. Datasets with outliers are not handled well by standard non-linear least squares methods, and manual outlier removal after visual inspection is tedious and potentially biased. We propose robust non-linear regression via M-estimation as a statistical technique for automated implementation. The approach of finding M-estimates by Iteratively Reweighted Least Squares (IRLS) and the resulting optimization problem are described. Initial parameter estimates for iterative methods are important, so self-starting methods for our model are presented. We outline the software implementation, done in Matlab and deployed as an Excel application via the Matlab Excel Builder Toolkit. Results of M-estimation are compared with least squares estimates before and after manual editing.     

Robustness of representations in multilayer feedforward neural networks

Recent research has shown that multilayer feedforward networks with sigmoidal activation functions are universal approximators, and that this holds for more general activations as well. The mathematical underpinning for these results has been various: Kolmogorov's resolution of Hilbert's thirteenth problem; the Stone-Weierstrass theorem; approximation of Fourier and Radon integral representations; and convergence of probability measures. This paper

Bismuth crystal twinning in thermal cycling

It was found that thermal cycling of monocrystalline bismuth in a regime of (77 373°K) leads to the appearance of a network of system {110} thermal twins in the surface layer of the specimens, accompanied by a decrease in microhardness at low loading.Translated from Inzhenerno-Fizicheskii Zhurnal, Vol. 39, No. 1, pp. 148–149, July, 1980.     

Thermal explosion in a hot gas mixture with organic gel fuel droplets

Recent experimental evidence has uncovered the peculiar behavior of certain gel droplets which, under appropriate ambient thermal conditions, evaporate and burn in an oscillatory fashion. In this work a preliminary foray is made into the theoretical analysis of the nature of the evolution of a hot gas mixture containing organic gel fuel droplets with oscillatory evaporation within the context of thermal-explosion theory. The problem is modeled as a system of highly nonlinear singularly perturbed ordinary differential equations. Non-dimensionalization of the equations enables identification of the parameters that play a major role in determining the dynamical regimes of the system of equations. The method of integral manifolds is exploited for the analysis and it is found, that for certain parametric regions, the system exhibits new dynamical behavior that is quite different from that found for conventional liquid droplets.     

磁控溅射法镀制氮化铝薄膜特性研究

氮化铝薄膜具有高折射率,良好的化学稳定性,耐磨摩、高电阻等特性在微电子器件和光学薄膜中有着广泛地应用.本文研究了反应式磁控溅射方法利用Ar/N2混合气体镀制氮化铝薄膜的工艺过程,实验表明在高真空和高泵浦速率条件下,放电电压直接依赖于反应气体珠浓度.薄膜的折射率,消光系数和薄膜硬度都依赖于氮气浓度的比例.通过工艺研究,找到了氮气在不同浓度下对氮化铝薄膜的折射率,消光系数以及薄膜硬度的影响,找出了镀制氮化镀制氮化铝薄膜的最佳工艺参数.在Ar/N2工作气体中氮气含量保持在40%条件下,用反应式磁控溅射方法,可以精确镀制出良好的氮化铝薄膜,其中折射率范围在2.25~2.4之间,消光系数为10-3,薄膜显微硬度大于20GPa.该薄膜可以广泛应用于微电子器件和光电器件上.     

Experimental heat transfer in supercritical water flowing inside channels (survey)

This literature survey is for heat transfer to supercritical water flowing in channels. The objectives are to assess the work that was done and to understand the specifics of heat transfer at these conditions. Our exhaustive literature search, which included over 450 papers, showed that the majority of experimental data were obtained in vertical tubes, some data in horizontal tubes and just a few in other flow geometries including bundles. In general, the experiments showed that there are three heat transfer modes in fluids at supercritical pressures: (1) normal heat transfer, (2) deteriorated heat transfer with lower values of the heat transfer coefficient (HTC) and hence higher values of wall temperature within some part of a test section compared to those of normal heat transfer and (3) improved heat transfer with higher values of the HTC and hence lower values of wall temperature within some part of a test section compared to those of normal heat transfer. The deteriorated heat transfer usually appears at high heat fluxes and lower mass fluxes. Also, a peak in HTC near the critical and pseudo-critical points was recorded. Due to the limited number of publications that are devoted to heat transfer in bundles cooled with water at supercritical pressures, more work is definitely needed to provide the additional information for design purposes.     

Micromechanical Modeling of the Effective Viscoelastic Properties of Inhomogeneous Materials Using Fraction-exponential Operators

A new analytical approach for’ micromechanical modeling of the effective viscoelastic behavior of a’ composite material is presented. Fractionexponential operators are. used to describe the viscoelastic properties of the constituents. To construct the corresponding elastic solution, effective field method is used. Effective viscoelastic operators are obtained from the Volter ra’s elasticity-viscoelasticity correspondence principle. Incompatible deformation that often occurs during the manufacturiig process is taken intp account. All the formulas are obtained in explicit ready-to-use form.     

Facial motion cloning

We propose a method for automatically copying facial motion from one 3D face model to another, while preserving the compliance of the motion to the MPEG-4 Face and Body Animation (FBA) standard. Despite the enormous progress in the field of Facial Animation, producing a new animatable face from scratch is still a tremendous task for an artist. Although many methods exist to animate a face automatically based on procedural methods, these methods still need to be initialized by defining facial regions or similar, and they lack flexibility because the artist can only obtain the facial motion that a particular algorithm offers. Therefore a very common approach is interpolation between key facial expressions, usually called morph targets, containing either speech elements (visemes) or emotional expressions. Following the same approach, the MPEG-4 Facial Animation specification offers a method for interpolation of facial motion from key positions, called Facial Animation Tables, which are essentially morph targets corresponding to all possible motions specified in MPEG-4. The problem of this approach is that the artist needs to create a new set of morph targets for each new face model. In case of MPEG-4 there are 86 morph targets, which is a lot of work to create manually. Our method solves this problem by cloning the morph targets, i.e. by automatically copying the motion of vertices, as well as geometry transforms, from source face to target face while maintaining the regional correspondences and the correct scale of motion. It requires the user only to identify a subset of the MPEG-4 Feature Points in the source and target faces. The scale of the movement is normalized with respect to MPEG-4 normalization units (FAPUs), meaning that the MPEG-4 FBA compliance of the copied motion is preserved. Our method is therefore suitable not only for cloning of free facial expressions, but also of MPEG-4 compatible facial motion, in particular the Facial Animation Tables. We believe that Facial Motion Cloning offers dramatic time saving to artists producing morph targets for facial animation or MPEG-4 Facial Animation Tables.     

FREQUENCY DOMAIN ANALYSIS OF FAST AND SLOW MOTIONS IN SLIDING MODES

A frequency domain approach to analysis of fast and slow motions in sliding modes is proposed in the paper. The proposed approach is based on the construction of a relay system that is equivalent to the original sliding mode control system and on the application of the locus of a perturbed relay system method. A precise model of the fast motions and a non‐reduced order model of the slow motions for the SISO linear time‐invariant case are obtained as a result of the proposed approach.