全文获取类型
收费全文 | 44588篇 |
免费 | 4572篇 |
国内免费 | 2708篇 |
专业分类
电工技术 | 3230篇 |
技术理论 | 1篇 |
综合类 | 5406篇 |
化学工业 | 6369篇 |
金属工艺 | 2432篇 |
机械仪表 | 3271篇 |
建筑科学 | 3377篇 |
矿业工程 | 1619篇 |
能源动力 | 1441篇 |
轻工业 | 3667篇 |
水利工程 | 1330篇 |
石油天然气 | 2408篇 |
武器工业 | 718篇 |
无线电 | 4381篇 |
一般工业技术 | 3748篇 |
冶金工业 | 2521篇 |
原子能技术 | 501篇 |
自动化技术 | 5448篇 |
出版年
2024年 | 157篇 |
2023年 | 523篇 |
2022年 | 1218篇 |
2021年 | 1695篇 |
2020年 | 1340篇 |
2019年 | 1022篇 |
2018年 | 1287篇 |
2017年 | 1305篇 |
2016年 | 1298篇 |
2015年 | 1646篇 |
2014年 | 2159篇 |
2013年 | 2390篇 |
2012年 | 2999篇 |
2011年 | 2896篇 |
2010年 | 2796篇 |
2009年 | 2600篇 |
2008年 | 2619篇 |
2007年 | 3139篇 |
2006年 | 3201篇 |
2005年 | 2301篇 |
2004年 | 2202篇 |
2003年 | 2423篇 |
2002年 | 1988篇 |
2001年 | 1740篇 |
2000年 | 1209篇 |
1999年 | 724篇 |
1998年 | 676篇 |
1997年 | 499篇 |
1996年 | 382篇 |
1995年 | 261篇 |
1994年 | 193篇 |
1993年 | 178篇 |
1992年 | 118篇 |
1991年 | 99篇 |
1990年 | 85篇 |
1989年 | 60篇 |
1988年 | 92篇 |
1987年 | 55篇 |
1986年 | 42篇 |
1985年 | 41篇 |
1984年 | 24篇 |
1983年 | 30篇 |
1982年 | 15篇 |
1981年 | 14篇 |
1980年 | 20篇 |
1979年 | 10篇 |
1977年 | 21篇 |
1976年 | 38篇 |
1959年 | 10篇 |
1951年 | 7篇 |
排序方式: 共有10000条查询结果,搜索用时 296 毫秒
71.
JI Kourie 《Canadian Metallurgical Quarterly》1997,157(1):39-51
In addition to its role in olfaction and as a primary epileptogenic site, the anterior piriform cortex has been suggested to play a role in neuroperception of deficiencies or imbalances in physiologically essential amino acids. In recent studies, amino acid deficient diets were shown to induce expression of c-fos in the anterior piriform cortex within the rapid time frame associated with the normal anorectic response to such diets. It became important to examine the neurocytochemical architecture of this region for clues as to how and more precisely where dietary amino acid deficiency or imbalance might be monitored. The relationships of neuropeptide Y-, somatostatin-, and cholecystokinin-containing neurons were of particular interest because ongoing studies indicate that those peptides administered to the anterior piriform cortex alter intake of diets deficient in essential amino acids. The neuropeptides were endogenous to intrinsic neurons only; none resembled pyramidal projection neurons. Peptidergic neurons and fibers were concentrated most heavily in layer III of the paleocortex. The cytoarchitecture suggests that neuropeptide Y-, somatostatin-, and cholecystokin-containing neurons of the anterior piriform cortex may relate synaptically or multisynaptically to local circuit neurons during electrical activity, modulation of olfactory information, and neuroperception of essential amino acids. 相似文献
72.
Sperm-induced Ca2+ signals mediate the events of oocyte activation at fertilization. In this study, the development of mechanisms involved in the generation of Ca2+ signals in human oocytes was investigated. The thiol reagent, thimerosal, which induces oscillations of intracellular Ca2+ ([Ca2+]i) similar to those seen during fertilization, was used to mobilize Ca2+ in in-vivo matured, immature and in-vitro matured human oocytes. There was an increase in the sensitivity to thimerosal during maturation of human oocytes, with oocytes from small antral follicles being relatively insensitive, compared with those from luteinized follicles, which displayed a large spike followed by sustained oscillations in [Ca2+]i. These oscillations were inhibited by caffeine which suggests that they were mediated by the inositol trisphosphate receptor Ca2+ release system. When immature oocytes were cultured in vitro they acquired the capacity to undergo a single large spike in [Ca2+]i, however, subsequent sustained oscillations were not observed, indicating that these oocytes failed to develop fully competent Ca2+ signalling mechanisms during culture in vitro. This finding may be a key factor in the poor developmental competence of in-vitro matured human oocytes. 相似文献
73.
7-hydroxystaurosporine (UCN-01) is a more selective protein kinase C inhibitor than staurosporine. UCN-01 exhibits antitumor activity in experimental tumor models and is presently in clinical trials. Our study reveals that human myeloblastic leukemia HL60 and K562 and colon carcinoma HT29 cells undergo internucleosomal DNA fragmentation and morphological changes characteristic of apoptosis after UCN-01 treatment. These three cell lines lack functional p53, and K562 and HT29 cells are usually resistant to apoptosis. DNA fragmentation in HT29 and K562 cells occurred after 1 day of treatment while it took less than 4 h in HL60 cells. Cycloheximide prevented UCN-01-induced DNA fragmentation in HT-29 cells, but not in HL60 and K562 cells, suggesting that macromolecular synthesis is selectively required for apoptotic DNA fragmentation in HT29 cells. UCN-01-induced DNA fragmentation was preceded by activation of cyclin B1/cdc2 kinase. Further studies in HL60 cells showed that UCN-01-induced apoptosis was associated with degradation of CPP32, PARP, and lamin B and that the inhibitor of caspases (ICE/CED-3 cysteine proteases), Z-VAD-FMK, and the serine protease inhibitor, DCI, protected HL60 cells from UCN-01-induced DNA fragmentation. However, only DCI and TPCK, but not Z-VAD-FMK, inhibited DNA fragmentation in the HL60 cell-free system, suggesting that serine protease(s) may play a role in the execution phase of apoptosis in HL60 cells treated with UCN-01. Z-VAD-FMK and DCI also inhibited apoptosis in HT29 cells. These data demonstrate that the protein kinase C inhibitor and antitumor agent, UCN-01 is a potent apoptosis inducer in cell lines that are usually resistant to apoptosis and lack p53 and that caspases and probably serine proteases are activated during UCN-01-induced apoptosis. 相似文献
74.
广义杠杆规则及其在配方计算中的应用 总被引:5,自引:3,他引:2
作者将相图中的一维杠杆规则推广至多元配料系统而成为广义杠杆规则,并利用这一规则对配方计算中解的可行域问题进行了深入的讨论,给出了几何解释及工艺诠释,对配方设计有一定的指导作用。 相似文献
75.
YC Lo L Brett CJ Kenyon SD Morley JI Mason BC Williams 《Canadian Metallurgical Quarterly》1998,24(3-4):559-563
We have employed polyclonal antibodies to a peptide sequence of bovine steroidogenic acute regulatory (StAR) protein and human placental 3beta-hydroxysteroid dehydrogenase (3beta-HSD) to determine the localisation and distribution of these proteins in rat and bovine adrenal glands. Immunohistochemical staining demonstrated the presence of StAR protein in the zona glomerulosa (ZG), zona fasciculata (ZF), zona reticularis (ZR) and in the medulla of both species. For 3beta-HSD, immunostaining was observed in the ZG, ZF and ZR of the rat adrenal and was absent in the medulla. Immunoblotting experiments showed intense bands for StAR protein (30 kDa, 37 kDa) in the mitochondria of bovine ZG, ZF and medulla and a less intense band (30 kDa) in the microsomes. In rat ZG and ZF/R mitochondria only the 30 kDa protein was present. For 3beta-HSD, an intense band (42 kDa) was found in microsomes and mitochondria of rat and bovine ZG and ZFR. A very faint signal for 3beta-HSD was seen in adrenal medulla. In conclusion, StAR (or a closely related) protein is present throughout the adrenal gland in rat and bovine species in contrast to 3beta-HSD which is confined to the steroidogenic zones. The possible function of StAR protein in the adrenal medulla merits investigation. 相似文献
76.
77.
Forty-three rescuers responding to a bus crash that killed 12 children and 4 adults and injured many more answered questionnaires at 1 and 13 months following the crash. This study compared the responses of the voluntary and professional helpers, using the Impact of Event Scale (IES) and the General Health Questionnaire (GHQ). For all helpers taken together, the decline in IES-intrusion and IES-total scores was significant from 1 to 13 months. The voluntary helpers reported significantly more intrusion and avoidance on the IES at 1 month than professional helpers, and for avoidance the voluntary helpers still evidenced a significantly higher score than professional helpers at 13 months. The GHQ scores at 13 months reflected that the long-term negative impact of the event was low. 相似文献
78.
Z. -G. Fan Y. -X. Zhuang G. Yang R. Shao G. -F. Zhang 《Journal of Alloys and Compounds》1993,200(1-2):33-36
The oxygen absorption process in highly aligned YBa2Cu3Ox samples in air and in pure oxygen was studied at several constant temperatures. The process can be expressed in two steps, a chemical reaction controlled step and a diffusion controlled step. The kinetic equations are as follows respectively:
(1 − at) ln(1 − at) + at = kDt
The activation energy was calculated using an Arrhenius equation. The technical conditions of heat treatment for oxygen absorption of highly aligned YBa2Cu3Ox crystals are discussed. 相似文献
79.
80.
利用Sobolev插值不等式和关于时间t的先验估计,研究了一类广义耦合的具有周期初值问题的KdV方程,得到了整体解和整体吸引子的存在性。 相似文献