Bulk high-entropy hexaborides

For the first time, a group of CaB₆-typed cubic rare earth high-entropy hexaborides have been successfully fabricated into dense bulk pellets (>98.5 % in relative densities). The specimens are prepared from elemental precursors via in-situ metal-boron reactive spark plasma sintering. The sintered bulk pellets are determined to be single-phase without any detectable oxides or other secondary phases. The homogenous elemental distributions have been confirmed at both microscale and nanoscale. The Vickers microhardness are measured to be 16?18 GPa at a standard indentation load of 9.8 N. The nanoindentation hardness and Young’s moduli have been measured to be 19?22 GPa and 190?250 GPa, respectively, by nanoindentation test using a maximum load of 500 mN. The material work functions are determined to be 3.7–4.0 eV by ultraviolet photoelectron spectroscopy characterizations, which are significantly higher than that of LaB₆.     

Psychotherapy with HIV-infected clients: Factors influencing notification of third parties.

This article investigates psychologists' reactions to a hypothetical case involving an HIV-positive client who is involved in a monogamous relationship and whose behavior places his partner at risk. Results indicate that respondents attribute more responsibility to the client to protect his partner when the relationship is heterosexual rather than homosexual. Respondents attribute greater responsibility to the client's partner for self-protection when the relationship is a short-term, homosexual relationship. Regardless of relationship type, a majority of respondents feel an ethical responsibility to protect the partner and seem willing to break confidentiality to do so if necessary. There is not, however, clear agreement about this course of action. Alternative strategies for assisting client disclosure are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Work Setting and Burnout Among Professional Psychologists.

How does work setting relate to burnout among professional psychologists? Five hundred and seventy-one doctoral psychologists responded to a survey about professional activities, work environment, and burnout. Solo and group independent practitioners reported a greater sense of personal accomplishment than agency respondents. However, women experienced higher levels of emotional exhaustion in agency settings than in either solo or group independent practice, whereas men experienced higher exhaustion in group independent practice. Overall, greater emotional exhaustion was associated with less control over work activities, working more hours, spending more time on administrative tasks and paperwork, seeing more managed care clients and fewer direct pay clients, and having to deal with more negative client behaviors. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Sensor Geometry and Sampling Methods for Space-Variant Image Processing

: Space-variant imaging sensors have many advantages over conventional raster imaging sensors. They provide a large field of view for a given pixel count while maintaining a high resolution at the centre of the field of view and, in addition, produce a mapping that is scale and rotation invariant. The effectiveness of the sensor depends greatly upon the geometry used and the sampling methods employed. In this paper, we define a sensor geometry and introduce an ideal weighted sampling method, where the pixels in the image lying at the intersection of sensor cells, are subdivided into smaller sub-pixels, and an interpolation method using a variable width interpolation mask, whose size varies exponentially with the size and shape of the cells in the sensor array. We compare the computational requirements of these methods, and show that they are scale and rotation invariant, when the image is scaled or rotated about its centre, giving the sensor a functionality similar to that provided by the retinal mapping present in the mammalian retina. These results illustrate the advantages that can be obtained in real-time tracking applications in computer vision, where computational and memory requirements need to be kept to a minimum. Received: 29 August 2001, Received in revised form: 15 January 2002, Accepted: 15 January 2002 ID="A1" Correspondence and offprint requests to: R. Young, School of Engineering and Information Technology, University of Sussex, Brighton, Sussex BN1 9QT, UK. Email: r.c.d.young@sussex.co.uk     

Functional Patterning of Biopolymer Thin Films Using Enzymes and Lithographic Methods

Two different lithographic techniques for the patterning of thin biopolymer films are developed. The first method is based on using a microstructured elastomeric mold for the structuring of thin films of regenerated cellulose. The thin films are manufactured by spin‐coating of trimethylsilyl cellulose (TMSC) and subsequent regeneration. The microchannels formed by the mold and the cellulose film are filled with a cellulase solution by capillary action. In the areas exposed to the enzyme solution, the cellulose film is digested, whereas the area in contact with the mold is protected from the enzymatic activity. Optical thickness measurements, atomic force microscopy and fluorescent staining confirm a successful patterning of cellulose on several substrates by this method. The second method is based on the structured regeneration of thin TMSC films. TMSC surfaces are protected with metal masks and exposed to vapors of hydrochloric acid. These treatments result in hydrophilic cellulose structures surrounded by hydrophobic TMSC with differing physicochemical properties. Treatments of the obtained structures with cellulases allow the selective removal of pure cellulose, whereas a TMSC pattern remains on the surface. These TMSC can be regenerated back to pure cellulose by treatments with vapors of hydrochloric acid. The developed methods allow the effective fabrication of micropatterned biopolymer thin films suitable for further functionalization and application in, e.g., bioanalytical devices. This is shown by the immobilization and detection of single‐stranded DNA on structured cellulose surfaces. Owing to the versatility of both patterning approaches the methods can be further extended to other combinations of substrates and enzymes.     

Differential Regulation of cGMP Signaling in Human Melanoma Cells at Altered Gravity: Simulated Microgravity Down-Regulates Cancer-Related Gene Expression and Motility

Altered gravity is known to affect cellular function by changes in gene expression and cellular signaling. The intracellular signaling molecule cyclic guanosine-3^′,5^′-monophosphate (cGMP), a product of guanylyl cyclases (GC), e.g., the nitric oxide (NO)-sensitive soluble GC (sGC) or natriuretic peptide-activated GC (GC-A/GC-B), is involved in melanocyte response to environmental stress. NO-sGC-cGMP signaling is operational in human melanocytes and non-metastatic melanoma cells, whereas up-regulated expression of GC-A/GC-B and inducible NO synthase (iNOS) are found in metastatic melanoma cells, the deadliest skin cancer. Here, we investigated the effects of altered gravity on the mRNA expression of NOS isoforms, sGC, GC-A/GC-B and multidrug resistance-associated proteins 4/5 (MRP4/MRP5) as selective cGMP exporters in human melanoma cells with different metastatic potential and pigmentation. A specific centrifuge (DLR, Cologne Germany) was used to generate hypergravity (5 g for 24 h) and a fast-rotating 2-D clinostat (60 rpm) to simulate microgravity values ≤?0.012 g for 24 h. The results demonstrate that hypergravity up-regulates the endothelial NOS-sGC-MRP4/MRP5 pathway in non-metastatic melanoma cells, but down-regulates it in simulated microgravity when compared to 1 g. Additionally, the suppression of sGC expression and activity has been suggested to correlate inversely to tumor aggressiveness. Finally, hypergravity is ineffective in highly metastatic melanoma cells, whereas simulated microgravity down-regulates predominantly the expression of the cancer-related genes iNOS and GC-A/GC-B (shown additionally on protein levels) as well as motility in comparison to 1 g. The results suggest that future studies in real microgravity can benefit from considering GC-cGMP signaling as possible factor for melanocyte transformation.     

Haptic collision handling for simulation of transnasal surgery

Simulation of endoscopic navigation in the narrow nasal cavity poses important challenges to the computation of adequate and near‐realistic collision response and haptic feedback because extensive multidirectional contact and massive tissue deformations are inevitable. We present a virtual coupling algorithm that provides stable collision response as well as intuitive and smooth haptic interaction in all phases of the simulation. In each iteration, continuous collision detection between the point shell representing the surface of the virtual patient anatomy and the endoscope, represented by a cylinder, is performed. This allows for rolling back the instrument movement to the point in time the first collision occurred. Subsequently, a relaxation process locally optimizes the position and orientation of the instrument. A novel method of applying contact forces to colliding tissues and thus triggering appropriate deformations improves the fluency of navigation. This paper describes the algorithm and presents experimental results. © Her Majesty the Queen in Right of Canada 2012. Reproduced with the permission of the Minister of Medical Devices, National Research Council Canada.     

Strong Markov random field model

The strong Markov random field (strong-MRF) model is a submodel of the more general MRF-Gibbs model. The strong-MRF model defines a system whose field is Markovian with respect to a defined neighborhood, and all subneighborhoods are also Markovian. A checkerboard pattern is a perfect example of a strong Markovian system. Although the strong Markovian system requires a more stringent assumption about the field, it does have some very nice mathematical properties. One mathematical property is the ability to define the strong-MRF model with respect to its marginal distributions over the cliques. Also, a direct equivalence to the Analysis-of-Variance (ANOVA) log-linear construction can be proven. From this proof, the general ANOVA log-linear construction formula is acquired.