A Novel Kind of Wideband Low-Profile Dielectric Resonator Antenna Suitable for Beam-scanning Applications

In this paper, a low-profile wideband dielectric resonator antenna(DRA) with a very compact planar size is investigated. The antenna consists of a high permittivity dielectric sheet on the top, a low permittivity substrate in the middle, and a probe feeding structure at the bottom. By digging an annular slot in the designated area of the square dielectric sheet, the resonant frequency of fundamental TE111 mode can be effectively increased to be close to the high-order TE131 mode. The two modes c...     

记者外出采访的必备设备——Mini采集、编辑、回传系统

作为当代新闻记者,需要在第一时间采访到节目素材并在第一时间播出.结合实例,给出了一个适于记者外出采访,能够完成采集、编辑、回传工作的Mini系统.     

传动带成型机张力控制系统的优化设计

通过对传动带成型机张力控制系统的控制方案进行比较与分析,优化设计了以单片机为核心、以磁粉制动器为执行元件的恒张力控制系统。该张力控制系统采用智能调节,能进行参数修改、调节变频器加减速曲线及时间常数,可防止卷绕物拉断,具有在线监视、通讯功能,系统操作方便、直观,排线间距控制精度较高,能大幅度提高传动带成品率,具有推广应用价值。     

Systematic adsorption process of petroleum hydrocarbon by immobilised petroleum-degradation bacteria system in degradation pathways

In order to effectively control petroleum hydrocarbon pollution by immobilisation technology,it is necessary to understanding the degradation pathways of petrol...     

Bile Acid–Drug Interaction via Organic Anion-Transporting Polypeptide 4C1 Is a Potential Mechanism of Altered Pharmacokinetics of Renally Excreted Drugs

Patients with liver diseases not only experience the adverse effects of liver-metabolized drugs, but also the unexpected adverse effects of renally excreted drugs. Bile acids alter the expression of renal drug transporters, however, the direct effects of bile acids on drug transport remain unknown. Renal drug transporter organic anion-transporting polypeptide 4C1 (OATP4C1) was reported to be inhibited by chenodeoxycholic acid. Therefore, we predicted that the inhibition of OATP4C1-mediated transport by bile acids might be a potential mechanism for the altered pharmacokinetics of renally excreted drugs. We screened 45 types of bile acids and calculated the IC₅₀, K_i values, and bile acid–drug interaction (BDI) indices of bile acids whose inhibitory effect on OATP4C1 was >50%. From the screening results, lithocholic acid (LCA), glycine-conjugated lithocholic acid (GLCA), and taurine-conjugated lithocholic acid (TLCA) were newly identified as inhibitors of OATP4C1. Since the BDI index of LCA was 0.278, LCA is likely to inhibit OATP4C1-mediated transport in clinical settings. Our findings suggest that dose adjustment of renally excreted drugs may be required in patients with renal failure as well as in patients with hepatic failure. We believe that our findings provide essential information for drug development and safe drug treatment in clinics.     

HDAC8-Selective Inhibition by PCI-34051 Enhances the Anticancer Effects of ACY-241 in Ovarian Cancer Cells

HDAC6 is overexpressed in ovarian cancer and is known to be correlated with tumorigenesis. Accordingly, ACY-241, a selective HDAC6 inhibitor, is currently under clinical trial and has been tested in combination with various drugs. HDAC8, another member of the HDAC family, has recently gained attention as a novel target for cancer therapy. Here, we evaluated the synergistic anticancer effects of PCI-34051 and ACY-241 in ovarian cancer. Among various ovarian cancer cells, PCI-34051 effectively suppresses cell proliferation in wild-type p53 ovarian cancer cells compared with mutant p53 ovarian cancer cells. In ovarian cancer cells harboring wild-type p53, PCI-34051 in combination with ACY-241 synergistically represses cell proliferation, enhances apoptosis, and suppresses cell migration. The expression of pro-apoptotic proteins is synergistically upregulated, whereas the expressions of anti-apoptotic proteins and metastasis-associated proteins are significantly downregulated in combination treatment. Furthermore, the level of acetyl-p53 at K381 is synergistically upregulated upon combination treatment. Overall, co-inhibition of HDAC6 and HDAC8 through selective inhibitors synergistically suppresses cancer cell proliferation and metastasis in p53 wild-type ovarian cancer cells. These results suggest a novel approach to treating ovarian cancer patients and the therapeutic potential in developing HDAC6/8 dual inhibitors.     

Early Expression of Tet1 and Tet2 in Mouse Zygotes Altered DNA Methylation Status and Affected Embryonic Development

Ten-eleven translocation (Tet) dioxygenases can induce DNA demethylation by catalyzing 5-methylcytosine(5mC) to 5-hydroxymethylcytosine(5hmC), and play important roles during mammalian development. In mouse, Tet1 and Tet2 are not expressed in pronucleus-staged embryos and are not involved in the genomic demethylation of early zygotes. Here, we investigated the influence of Tet1 and Tet2 on methylation of parental genomes by ectopically expressing Tet1 and Tet2 in zygotes. Immunofluorescence staining showed a marked 5hmC increase in the maternal pronucleus after injection of Tet1 or Tet2 mRNA into zygotes. Whole-genome bisulfite sequencing further revealed that Tet2 greatly enhanced the global demethylation of both parental genomes, while Tet1 only promoted the paternal demethylation. Tet1 and Tet2 overexpression altered the DNA methylation across genomes, including various genic elements and germline-specific differently methylated regions. Tet2 exhibited overall stronger demethylation activity than Tet1. Either Tet1 or Tet2 overexpression impaired preimplantation embryonic development. These results demonstrated that early expression of Tet1 and Tet2 could substantially alter the zygotic methylation landscape and damage embryonic development. These findings provide new insights into understanding the function of Tet dioxygenases and the mechanism of DNA methylation in relation to embryogenesis.     

运动模糊图像的维纳滤波复原研究

根据运动造成图像模糊的特点详细分析了匀速直线运动模糊图像的退化模型和恢复模型,提出直接在运动方向上建立点扩展函数的算法,并利用改进的霍夫变换检测点扩散参数,再利用二次维纳滤波的方法复原图像。通过实验表明在图像先验条件的要求没有增加的情况下,该方法提高图了像复原的抗噪性和稳定性,并且有效的保持图像细节。     

用不对称醚作调节剂合成苯乙烯-异戊二烯-丁二烯橡胶的反应动力学

以苯乙烯(St)、异戊二烯(Ip)和丁二烯(Bd)为单体,正丁基锂(n-BuLi)为引发荆,乙基乙二醇叔丁基醚(BET)为结构调节剂,合成了线型无规结构的苯乙烯-异戊二烯-丁二烯橡胶(SIBR),进行了聚合反应动力学研究,并与以四氢呋喃(THF)为结构调节剂的体系进行了比较.结果表明,BET的加入提高了聚合反应速率;随反应温度的升高和BET/n-BuLi(摩尔比)的增大,聚合反应速率加快,尤其是St的反应速率提高显著;BET调节聚合速率的能力明显高于THF.     

PET中环状低聚物的表征及控制方法的研究进展

鉴于环状低聚物的诸多危害,归纳了PET中环状低聚物的表征方法,具体介绍了低聚物的分离方法及其性能的研究方法,重点总结了目前减少环状低聚物含量的一些新的措施和方法,以期为今后的相关研究提供参考,并提出应该建立工业上简便易行的环状低聚物含量检测方法。