体育场馆照明工程常见问题与解决方法

随着大量的各种类型的体育场馆的兴建,体育场馆的照明工程成为建筑电气行业的一个重要分支.在场馆建设时应根据实际需要进行照明设计和施工,做到场馆的照明满足体育赛事在安全、可靠、达标方面的要求,并且兼顾赛时与赛后照明设施的充分利用,达到既经济又实用的目的.体育场馆照明工程设计和施工中存在一些常见的缺陷,在设计和施工中应认真加以研究,以保证工程的质量.     

HDAC8-Selective Inhibition by PCI-34051 Enhances the Anticancer Effects of ACY-241 in Ovarian Cancer Cells

HDAC6 is overexpressed in ovarian cancer and is known to be correlated with tumorigenesis. Accordingly, ACY-241, a selective HDAC6 inhibitor, is currently under clinical trial and has been tested in combination with various drugs. HDAC8, another member of the HDAC family, has recently gained attention as a novel target for cancer therapy. Here, we evaluated the synergistic anticancer effects of PCI-34051 and ACY-241 in ovarian cancer. Among various ovarian cancer cells, PCI-34051 effectively suppresses cell proliferation in wild-type p53 ovarian cancer cells compared with mutant p53 ovarian cancer cells. In ovarian cancer cells harboring wild-type p53, PCI-34051 in combination with ACY-241 synergistically represses cell proliferation, enhances apoptosis, and suppresses cell migration. The expression of pro-apoptotic proteins is synergistically upregulated, whereas the expressions of anti-apoptotic proteins and metastasis-associated proteins are significantly downregulated in combination treatment. Furthermore, the level of acetyl-p53 at K381 is synergistically upregulated upon combination treatment. Overall, co-inhibition of HDAC6 and HDAC8 through selective inhibitors synergistically suppresses cancer cell proliferation and metastasis in p53 wild-type ovarian cancer cells. These results suggest a novel approach to treating ovarian cancer patients and the therapeutic potential in developing HDAC6/8 dual inhibitors.     

Melanocortin-5 Receptor: Pharmacology and Its Regulation of Energy Metabolism

As the most recent melanocortin receptor (MCR) identified, melanocortin-5 receptor (MC5R) has unique tissue expression patterns, pharmacological properties, and physiological functions. Different from the other four MCR subtypes, MC5R is widely distributed in both the central nervous system and peripheral tissues and is associated with multiple functions. MC5R in sebaceous and preputial glands regulates lipid production and sexual behavior, respectively. MC5R expressed in immune cells is involved in immunomodulation. Among the five MCRs, MC5R is the predominant subtype expressed in skeletal muscle and white adipose tissue, tissues critical for energy metabolism. Activated MC5R triggers lipid mobilization in adipocytes and glucose uptake in skeletal muscle. Therefore, MC5R is a potential target for treating patients with obesity and diabetes mellitus. Melanocortin-2 receptor accessory proteins can modulate the cell surface expression, dimerization, and pharmacology of MC5R. This minireview summarizes the molecular and pharmacological properties of MC5R and highlights the progress made on MC5R in energy metabolism. We poInt. out knowledge gaps that need to be explored in the future.     

P2P computing for intelligence of things

Peer-to-Peer Networking and Applications -     

Open-circuit fault detection for three-phase inverter based on backpropagation neural network

Neural Computing and Applications - To realize real-time fault detection in power devices and enhance reliability of inverter circuits, this paper proposes a detection method based on Park’s...     

需求管理及配置管理与项目范围管理

需求管理、配置管理和项目范围管理在软件项目管理中具有重要的地位和作用。透彻分析了需求管理、配置管理和项目范围管理知识理论中的基本概念,有助于形成对需求管理、配置管理和项目范围管理的深刻理解,有利于规范和促进日常项目管理工作。     

某铀矿井场抽注液控制的数字化技术应用

在地浸采铀生产过程中,控制抽注液平衡和高效识别抽注液异常状态是保障浸出效能和井场的安全重要措施。以内蒙古某铀矿为例,介绍了该铀矿抽注液平衡联动控制与抽注液异常监测方面数字化技术的应用情况,探讨了应用数字化技术前后该铀矿山抽注液管控效能的变化。结果表明,应用数字化技术进行抽注液平衡控制能有效解决抽注液调控过程中人工控制所存在的劳动强度大、调控不及时和精度不足的问题;合理的模型设计能够高效识别抽注液异常状态。建立抽注液数字化管控体系有助于实现精益化管控、提升井场生产效能、降低安全风险。     

贵州电网输电线路在线监测系统运行分析

通过介绍贵州电网输电线路在线监测系统的应用和运行情况,对系统在运行过程中发生的缺陷和故障进行了统计和梳理,通过对故障原因的分析,提出了相应的改进对策。     

Influence of hexapod robot foot shape on sinking considering multibody dynamics

Journal of Mechanical Science and Technology - Hexapod robots have attracted attention for their excellent terrain adaptabilities. When a robot walks on soft soil, dynamic subsidence and slippage...     

Green cell association for multimedia transmission in cognitive heterogeneous networks

With the introduction of low‐powered pico/femto‐base stations and relay nodes into the macro‐cell, recent heterogeneous networks provide an attractive approach for future wireless communication. Although it may achieve better coverage and higher capacity, several problems remain unsolved before practical deployment. For example, how to select the proper cell from neighbor low‐powered cells and then occupy the radio resource without interference on macro‐users is both important and challenging, especially for rigorous multimedia applications. The traditional cell access algorithms and quality‐control parameters such as delay or throughput no longer suit well in this complex environment. An effective approach should be pursued. In this paper, we investigate this interesting cell association problem and propose a complete green resolution on the basis of thorough discussions about the multimedia transmission under these concerns. Cognitive radio is introduced to share spectrum between macro‐cell and low‐powered cells while securing the transmission of authorized macro‐users. We also bring forth the concept of ‘interference balance’ to better manage the overall interference and energy consumption in the network. Restless bandit model is formulated on the basis of channel state, data rate, interference control, and the carefully chosen intra‐refreshing rate for multimedia traffic. Then the cell association scheme is designed to be efficient and practical because of the simple index property of our model output. Simulation results have proven the performance of our proposed resolution compared with existing algorithms on interference constraint, multimedia distortion, and overall network energy consumption balance. Copyright © 2013 John Wiley & Sons, Ltd.