Decline in striatal dopamine D1 and D2 receptor activation in aged F344 rats

Aging differentially affects receptor function. In the present electrophysiological study we compared neuronal responsiveness to locally applied dopamine D1 and D2 receptor agonist in the striatum of female Fischer 344 rats aged 3 and 26-27 months. In a subgroup of the old rats, the nigrostriatal dopamine bundle was destroyed unilaterally with 6-hydroxydopamine (6-OHDA) to assess receptor plasticity in response to denervation. Spontaneous firing rate of striatal neurons was higher in aged compared to young rats. Higher doses of the D1 agonist SKF 38393 or the D2 agonist quinpirole were required to elicit a 50% change in firing rate in aged compared to young rats. No difference with SKF 38393 or quinpirole was detected between 6-OHDA denervated and control (nonlesioned) striatum in aged rats. Supersensitivity to D2 agonists has been reported following 6-OHDA lesions in young rats. These observations suggest that D2 receptors in aged rat striatum might not be as plastic as in younger rats.     

Einfluß der Schrottvorwärmung mit Erdgas und Sauerstoff im Konverter auf den Sauerstoffumsatz des LD-Verfahrens

Stand der Erkenntnisse und Ziel der eigenen Versuche. Anlagenbeschreibung und Betriebsbeobachtungen. Untersuchung der Schlackenbildung während der Schrottvorwärmung. Änderungen der Roheisenzusammensetzung durch Reaktionen mit den Vorwärmschlacken. Betrachtungen zur Sauerstoffbilanz.     

Equivalent circuit for injection-locked negative-resistance oscillators

Calculations are carried out for a van der Pol type oscillator with external force. It is illustrated how the condition of synchronisation is changed when (i) the admittance of the microwave diode is assumed to consist of an additional voltage-dependent susceptance and (ii) the frequency-determining resonator has a series reactance.     

Two software tools for plane-wave scattering on nonspherical particles in the German Aerospace Center's Virtual Laboratory

We present the methodological background, the range of applicability, and the on-line usage of two software packages, MIESCHKA and CYL, which we have developed for light-scattering analysis on nonspherical particles. MIESCHKA solves Maxwell's equations in a rigorous way but is restricted to axisymmetric geometries, whereas CYL is an approximation for finite columns with nonspherical cross sections. We have established an easy on-line access to both of these programs through the Virtual Laboratory. Its generic software infrastructure was designed to simplify the web-based usage and to support the intercomparability of scientific software.     

Assessing forest fire as a potential PCDD/F source in Queensland, Australia

Forest fires are suggested as a potential and significant source of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans (PCDD/Fs), even though no studies to date provide sufficient evidence to confirm forest fires as a source of PCDD/Fs. Recent investigations in Queensland, Australia have identified a widespread contamination of PCDDs (in particular OCDD) in soils and sediments in the coastal region from an unknown source of PCDD/Fs. Queensland is predominately rural; it has few known anthropogenic sources of PCDD/Fs, whereas forest fires are a frequent occurrence. This study was conducted to assess forest fires as a potential source of the unknown PCDD/F contamination in Queensland. A combustion experiment was designed to assess the overall mass of PCDD/Fs before and after a simulated forest fire. The results from this study did not identify an increase in sigmaPCDD/Fs or OCDD after the combustion process. However, specific non-2,3,7,8 substituted lower chlorinated PCDD/Fs were elevated after the combustion process, suggesting formation from a precursor. The results from this study indicate that forest fires are unlikely to be the source of the unknown PCDD contamination in Queensland, rather they are a key mechanism for the redistribution of PCDD/Fs from existing sources and precursors.     

Graph separators: a parameterized view

Graph separation is a well-known tool to make (hard) graph problems accessible to a divide-and-conquer approach. We show how to use graph separator theorems in combination with (linear) problem kernels in order to develop fixed parameter algorithms for many well-known NP-hard (planar) graph problems. We coin the key notion of glueable select&verify graph problems and derive from that a prospective way to easily check whether a planar graph problem will allow for a fixed parameter algorithm of running time for constant c. One of the main contributions of the paper is to exactly compute the base c of the exponential term and its dependence on the various parameters specified by the employed separator theorem and the underlying graph problem. We discuss several strategies to improve on the involved constant c.     

Cost accounting for shared IT infrastructures

IT infrastructure, such as servers and networking equipment, accounts for a large proportion of the IT costs in modern organizations. Typically, this IT infrastructure is shared among multiple applications and customers. Cost allocation of shared IT infrastructure is difficult and regularly based on biased cost allocation keys, which often causes free-rider problems. Measuring usage is technically difficult and incurs high costs. In this paper we propose a method to derive adequate estimators for the resource consumption of a customer-oriented service. These so-called resource profiles can then provide a basis for cost allocation keys. The estimators are derived from a series of load tests, as they are typically done before an application is launched in larger organizations. Such profiles need to be unbiased and precise even in cases of varying workloads and in rather heterogeneous environments. We describe the results of a set of experiments in an infrastructure provided by the BMW Group, and illustrate how the estimation can be integrated into existing IT service management processes. In our experiments we use Queuing Networks to validate the estimated resource profiles under different workloads.