Jonas Klein  Michael Philippi  Fatih Alarslan  Tim Jähnichen  Dirk Enke  Martin Steinhart  Markus Haase 《Small (Weinheim an der Bergstrasse, Germany)》2023,19(10):2207674

High-temperature treatment of functional nanomaterials, through postsynthesis calcination, often represents an important step to unlock their full potential. However, such calcination steps usually severely limit the preparation of colloidal solutions of the nanoparticles due to the formation of sintered agglomerates. Herein, a simple route is reported to obtain colloidal solutions of calcined n-conductive antimony doped tin oxide (ATO) as well as titanium dioxide (TiO₂) nanoparticles without the need for additional sacrificial materials. This is achieved by making use of the reduced contact between individual nanoparticles when they are assembled into aerogels. Following the calcination of the aerogels at 500 °C, redispersion of the nanoparticles into stable colloidal solutions with various solvents can be achieved. Although a slight degree of sintering is inevitable, the size of the resulting aggregates in solution is still remarkably small with values below 30 nm.  相似文献   

    

Juan S. Rocha-Ortiz  Jianchang Wu  Jonas Wenzel  Andreas J. Bornschlegl  Jose Dario Perea  Salvador Leon  Anastasia Barabash  Anna-Sophie Wollny  Dirk M. Guldi  Jiyun Zhang  Alberto Insuasty  Larry Lüer  Alejandro Ortiz  Andreas Hirsch  Christoph J. Brabec 《Advanced functional materials》2023,33(44):2304262

Dumbbell-shaped systems based on PAHs-BODIPY-triarylamine hybrids TM-(01-04) are designed as novel and highly efficient hole-transporting materials for usage in planar inverted perovskite solar cells. BODIPY is employed as a bridge between the PAH units, and the effects of the conjugated π-system's covalent attachment and size are investigated. Fluorescence quenching, 3D fluorescence heat maps, and theoretical studies support energy transfer within the moieties. The systems are extremely resistant to UVC 254 nm germicidal light sources and present remarkable thermal stability at degradation temperatures exceeding 350 °C. Integrating these systems into perovskite solar cells results in outstanding power conversion efficiency (PCE), with TM-02-based devices exhibiting a PCE of 20.26%. The devices base on TM-01, TM-03, and TM-04 achieve PCE values of 16.98%, 17.58%, and 18.80%, respectively. The long-term stability of these devices is measured for 600 h, with initial efficiency retention between 94% and 86%. The TM-04-based device presents noticeable stability of 94%, better than the reference polymer PTAA with 91%. These findings highlight the exciting potential of dumbbell-shaped systems based on PAHs-BODIPY-triarylamine derivatives for next-generation photovoltaics.  相似文献   

    

Wei Hu  Yaorui Hu  Yao Pei  Rongrong Li  Fuyi Xu  Xiaodong Chi  Jia Mi  Jonas Bergquist  Lu Lu  Luping Zhang  Chunhua Yang 《International journal of molecular sciences》2023,24(1)

Cervical carcinoma (CC) is the second most prevalent gynecologic cancer in females across the world. To obtain a better understanding of the mechanisms underlying the development of CC, high-resolution label-free mass spectrometry was performed on CC and adjacent normal tissues from eight patients. A total of 2631 proteins were identified, and 46 significant differently expressed proteins (DEPs) were found between CC and normal tissues (p < 0.01, fold change >10 or <0.1). Ingenuity pathway analysis revealed that the majority of the proteins were involved in the regulation of eIF4 and p70S6K signaling and mTOR signaling. Among 46 DEPs, Integrinβ6 (ITGB6), PPP1CB, TMPO, PTGES3 (P23) and DTX3L were significantly upregulated, while Desmin (DES) was significantly downregulated in CC tissues compared with the adjacent normal tissues. In in vivo and in vitro experiments, DTX3L knockdown suppressed CC cell proliferation, migration, invasion and xenograft tumorigenesis, and enhanced cell apoptosis. Combination of silencing DTX3L and cisplatin treatment induced higher apoptosis percentage compared to cisplatin treatment alone. Moreover, DTX3L silencing inhibited the PI3K/AKT/mTOR signal pathway. Thus, our results suggested DTX3L could regulate CC progression through the PI3K/AKT/mTOR signal pathway and is potentially a novel biomarker and therapeutic target for CC.  相似文献   

    

Jonas Oeing  Kevin Brandt  Michael Wiedau  Dr. Gregor Tolksdorf  Wolfgang Welscher  Prof. Dr.-Ing. Norbert Kockmann 《化学，工程师，技术》2023,95(7):1049-1060

Digitalization shows that data and its exchange are indispensable for a versatile and sustainable process industry. There must be a shift from a document-oriented to a data-oriented process industry. Standards for the harmonization of data structures play an essential role in this change. In engineering, DEXPI (Data Exchange in the Process Industry) is already a well-developed, machine-readable data standard for describing piping and instrumentation diagrams (P&ID). In this publication, industry, software vendors, and research institutions have joined forces to demonstrate the current developments and potentials of machine-readable P&IDs in the DEXPI format combined with artificial intelligence. The aim is to use graph neural networks to learn patterns in machine-readable P&ID data, which results in the efficient engineering and development of new P&IDs.  相似文献   

    

Dr. Erik Strandberg  Dr. Parvesh Wadhwani  Dr. Jochen Bürck  Dr. Patrick Anders  Dr. Christian Mink  Dr. Jonas van den Berg  Raffaele A. M. Ciriello  Dr. Manuel N. Melo  Prof. Dr. Miguel A. R. B. Castanho  Prof. Dr. Eduard Bardají  Prof. Dr. Jakob P. Ulmschneider  Prof. Dr. Anne S. Ulrich 《Chembiochem : a European journal of chemical biology》2023,24(4):e202200602

BP100 is a cationic undecamer peptide with antimicrobial and cell-penetrating activities. The orientation of this amphiphilic α-helix in lipid bilayers was examined under numerous conditions using solid-state ¹⁹F, ¹⁵N and ²H NMR. At high temperatures in saturated phosphatidylcholine lipids, BP100 lies flat on the membrane surface, as expected. Upon lowering the temperature towards the lipid phase transition, the helix is found to flip into an upright transmembrane orientation. In thin bilayers, this inserted state was stable at low peptide concentration, but thicker membranes required higher peptide concentrations. In the presence of lysolipids, the inserted state prevailed even at high temperature. Molecular dynamics simulations suggest that BP100 monomer insertion can be stabilized by snorkeling lysine side chains. These results demonstrate that even a very short helix like BP100 can span (and thereby penetrate through) a cellular membrane under suitable conditions.  相似文献   

    

Zhiyong Wang;Shuai Fu;Wenjie Zhang;Baokun Liang;Tsai-Jung Liu;Mike Hambsch;Jonas F. Pöhls;Yufeng Wu;Jianjun Zhang;Tianshu Lan;Xiaodong Li;Haoyuan Qi;Miroslav Polozij;Stefan C. B. Mannsfeld;Ute Kaiser;Mischa Bonn;R. Thomas Weitz;Thomas Heine;Stuart S. P. Parkin;Hai I. Wang;Renhao Dong;Xinliang Feng; 《Advanced materials (Deerfield Beach, Fla.)》2024,36(21):2311454

Two-dimensional van der Waals heterostructures (2D vdWhs) are of significant interest due to their intriguing physical properties critically defined by the constituent monolayers and their interlayer coupling. Synthetic access to 2D vdWhs based on chemically tunable monolayer organic 2D materials remains challenging. Herein, the fabrication of a novel organic–inorganic bilayer vdWh by combining π-conjugated 2D coordination polymer (2DCP, i.e., Cu3BHT, BHT = benzenehexathiol) with graphene is reported. Monolayer Cu3BHT with detectable µm2-scale uniformity and atomic flatness is synthesized using on-water surface chemistry. A combination of diffraction and imaging techniques enables the determination of the crystal structure of monolayer Cu3BHT with atomic precision. Leveraging the strong interlayer coupling, Cu3BHT-graphene vdWh exhibits highly efficient photoinduced interlayer charge separation with a net electron transfer efficiency of up to 34% from Cu3BHT to graphene, superior to those of reported bilayer 2D vdWhs and molecular-graphene vdWhs. This study unveils the potential for developing novel 2DCP-based vdWhs with intriguing physical properties.  相似文献   

    

Mirta Galesic  Henrik Olsson  Jonas Dalege  Tamara van der Does  Daniel L. Stein 《Journal of the Royal Society Interface》2021,18(176)

Belief change and spread have been studied in many disciplines—from psychology, sociology, economics and philosophy, to biology, computer science and statistical physics—but we still do not have a firm grasp on why some beliefs change more easily and spread faster than others. To fully capture the complex social-cognitive system that gives rise to belief dynamics, we first review insights about structural components and processes of belief dynamics studied within different disciplines. We then outline a unifying quantitative framework that enables theoretical and empirical comparisons of different belief dynamic models. This framework uses a statistical physics formalism, grounded in cognitive and social theory, as well as empirical observations. We show how this framework can be used to integrate extant knowledge and develop a more comprehensive understanding of belief dynamics.  相似文献   

    

Jonas Gregorio de Souza  Francisco Silva Noelli  Marco Madella 《Journal of the Royal Society Interface》2021,18(183)

The expansion of forest farmers across tropical lowland South America during the Late Holocene has long been connected to climate change. The more humid conditions established during the Late Holocene are assumed to have driven the expansion of forests, which would have facilitated the dispersal of cultures that practised agroforestry. The Tupi, a language family of widespread distribution in South America, occupies a central place in the debate. Not only are they one of the largest families in the continent, but their expansion from an Amazonian homeland has long been hypothesized to have followed forested environments wherever they settled. Here, we assess that hypothesis using a simulation approach. We employ equation-based and cellular automaton models, simulating demic-diffusion processes under two different scenarios: a null model in which all land cells can be equally settled, and an alternative model in which non-forested cells cannot be settled or delay the expansion. We show that including land cover as a constraint to movement results in a better approximation of the Tupi expansion as reconstructed by archaeology and linguistics.  相似文献   

    

Vasile Postica  Oleg Lupan  Anna Gapeeva  Luka Hansen  Rasoul Khaledialidusti  Abhishek Kumar Mishra  Jonas Drewes  Holger Kersten  Franz Faupel  Rainer Adelung  Sandra Hansen 《Advanced Materials Technologies》2021,6(5):2001137

The undoped and metal-doped zinc oxide columnar films (ZnO:Sn, ZnO:Fe, ZnO:Ag, and ZnO:Cu) are covered with an ultra-thin layer of SiO₂ (10–20 nm). The electrical, UV, and volatile organic compounds (VOCs) sensing properties are evaluated under different ambient conditions for ≈7 months to investigate the impact of the top SiO₂-layer on the long-term stability of samples. The obtained results show a high immunity of sensing properties of SiO₂-coated samples to humidity. Furthermore, gas sensing measurements show that the loss in response after 203 days is significantly lower for coated samples indicating higher stability of sensing performance. For ZnO:Fe the gas response is reduced by about 90% after 203 days, but for SiO₂-coated ZnO:Fe columnar films the gas response is slightly reduced by only 38%. The density functional theory (DFT) calculations show that water species bind strongly with the surface SiO₂ layer atoms with a −0.129 e⁻ charge transfer, which is, much higher compared to the interaction with ethanol and acetone. Calculations show strong binding of water species on the SiO₂ layer indicating preferential absorption of water molecules on SiO₂. The obtained results demonstrate an important role of the top SiO₂ ultra-thin layer in order to produce humidity-tolerant sensitive devices.  相似文献   

    

Mario Fleischer  Lukas Schumann  Anne Hartmann  Reuben Scott Walker  Liliana Ifrim  Dorothea von Zadow  Jonas Lüske  Joachim Seybold  Martin Kriegel  Dirk Mürbe 《Journal of the Royal Society Interface》2022,19(187)

Speaking and singing are activities linked to increased aerosol particle emissions from the respiratory system, dependent on the utilized vocal intensity. As a result, these activities have experienced considerable restrictions in enclosed spaces since the onset of the COVID-19 pandemic due to the risk of infection from the SARS-CoV-2 virus, transmitted by virus-carrying aerosols. These constraints have affected public education and extracurricular activities for children as well, from in-person music instruction to children’s choirs. However, existing risk assessments for children have been based on emission measurements of adults. To address this, we measured the particle emission rates of 15 pre-adolescent children, all eight to ten years old, with a laser particle counter for the test conditions: breathing at rest, speaking, singing and shouting. Compared with values taken from 15 adults, emission rates for breathing, speaking and singing were significantly lower for children. Particle emission rates were reduced by a factor of 4.3 across all conditions, whereas emitted particle volume rates were reduced by a factor of 4.8. These data can supplement SARS-CoV-2 risk management scenarios for various school and extracurricular settings.  相似文献