An interactive multiple-response simulation optimization method

This study proposes a new interactive multicriteria method for determining the best levels of the decision variables needed to optimize a stochastic computer simulation with multiple response variables. The method, called the Pairwise Comparison Stochastic Cutting Plane (PCSCP) method, combines good features from interactive multiple objective mathematical programming and response surface methodology. The major characteristics of the PCSCP method are: (1) it interacts progressively with the decision-maker (DM) to obtain her preferences, (2) it uses experimental design to explore the decision space adequately while reducing the burden on the DM, and (3) it uses the preference information provided by the DM and the sampling error in the responses to reduce the decision space. The mechanics of the method are illustrated with a numerical example. Some computational studies evaluating the method are also reported.     

Drug release from heat-treated polyvinyl alcohol films

Polyvinyl alcohol (PVA) films containing 10% w/w of a model drug, sulphathiazole, were cast from aqueous solutions and subjected to heat treatment at specific temperatures for known periods of time. Heat treatment at temperatures above the T_g of the PVA films slowed down the rate of drug release from the films. Increasing the temperature of heat treatment from 120°C to 160°C further decreased the rate of drug release. On the other hand, if the heat treatment were conducted at a temperature below the T_g e.g. at 80°C, there were insignificant differences between the release profile of sulphathiazole from heat-treated films and that from untreated films. The duration of heat treatment affected the rate of drug release to a smaller extent compared to the temperature of heat treatment. These results correlated with the heat induced changes in the morphology of, and in the extent of water uptake by the PVA films.     

Cying for Me, Cying for Us: Relational Dialectics in a Korean Social Network Site

This study employs a relational dialectics approach to gain insights into the nature of relational communication via Cyworld , a Korean social network site. Qualitative analysis of in-depth interview data from 49 users suggests that Cyworld users routinely negotiate multiple dialectical tensions that are created within the online world, transferred from face-to-face contexts, or imposed by interpersonal principles that relate to Korea's collectivistic culture. The interviewees experienced a new relational dialectic of interpersonal relations versus self-relation, analogous to Baxter and Montgomery's (1996) connection-autonomy contradiction. Their responses suggest that Cyworld's design features and functions encourage users to transcend the high-context communication of Korean culture by offering an alternative channel for elaborate and emotional communication, which fosters the reframing of relational issues offline. Cy-Ilchons (online buddies) virtually extend the Korean cultural concept of blood ties, called yons, in ways that intensify the openness-closedness contradiction at early stages of relationship formation.     

Parasitic Bipolar Junction Transistors in a Floating-Gate MOSFET for Fluorescence Detection

In this letter, we examined whether the parasitic bipolar junction transistors (BJTs) in the MOSFET fabricated by the standard CMOS process can play a role as a fluorescence detector. To suppress the action of two vertical parasitic BJTs, the gate and n-well were tied in the parasitic BJTs, and the body node was connected to the drain. The proposed device was compared with the inherent and the parasitic diodes in the MOSFET. It had 100 times higher photocurrents than the diodes in the MOSFET. In addition, it was applied for the detection of the fluorescent signal, and could detect near 10 nM of Alexa 546. Therefore, CMOS-process-compatible parasitic BJTs can be used as a photodetector in an integrated fluorescence detector.     

Thermal stratification and reactor piping integrity

Thermal stratification, cycling, and striping phenomena have drawn much attention recently because of the incidents at several nuclear plants that raised significant safety concerns. The concerns due to these phenomena relate to thermal fatigue in branch pipes connected to the main coolant piping. Nuclear utility industry is addressing the issue with the aim to understand the mechanisms that lead to fatigue in nominally stagnant piping systems near the reactor coolant piping. Two key results from this effort are described in this paper. First, tests to investigate the interaction between the main coolant piping and the stagnant attached lines by turbulence penetration are described and a working correlation is obtained. Turbulence penetration into unisolable lines, or the transport of turbulence into stagnant piping from the reactor coolant system (RCS) line, represents a mechanism for carrying hot RCS water into regions filled with cold water. The possibility of stratification of the two fluids (and the resultant thermal stresses) is the reason for developing an understanding of the turbulence penetration process. Secondly, results of an evaluation to develop a loading definition for thermal striping are included. Based on this testing several important conclusions relating to fatigue in nominally static reactor coolant systems are reached.