A sight on the current nanoparticle-based gene delivery vectors

Nowadays, gene delivery for therapeutic objects is considered one of the most promising strategies to cure both the genetic and acquired diseases of human. The design of efficient gene delivery vectors possessing the high transfection efficiencies and low cytotoxicity is considered the major challenge for delivering a target gene to specific tissues or cells. On this base, the investigations on non-viral gene vectors with the ability to overcome physiological barriers are increasing. Among the non-viral vectors, nanoparticles showed remarkable properties regarding gene delivery such as the ability to target the specific tissue or cells, protect target gene against nuclease degradation, improve DNA stability, and increase the transformation efficiency or safety. This review attempts to represent a current nanoparticle based on its lipid, polymer, hybrid, and inorganic properties. Among them, hybrids, as efficient vectors, are utilized in gene delivery in terms of materials (synthetic or natural), design, and in vitro/in vivo transformation efficiency.     

Using Fuzzy Cost‐Based FMEA,GRA and Profitability Theory for Minimizing Failures at a Healthcare Diagnosis Service

This paper proposes an integrated approach to identify, evaluate and improve the potential failures in a service setting. This integrated approach combines Fuzzy cost‐based service‐specific FMEA (FCS‐FMEA), Grey Relational Analysis (GRA) and profitability theory for better prioritization of the service failures by considering cost as an important issue and using the profitability theory in a way that the corrective actions costs are taken into account. Considering profitability with FCS‐FMEA and GRA reduces the losses caused by failure occurrence. Besides, a maximization linear mathematical problem is used to select the best mix of failures to be repaired. We apply our approach to an academic example concerning the potential failures diagnosis of the Internal Medicine service of a hospital located in Seoul, Korea. We applied our approach and solved the associated maximization problem by a commercial solver, producing an optimal solution which indicates the most convenient mix of failures to be repaired by considering available budget. Copyright © 2013 John Wiley & Sons, Ltd.     

Study of effect of old corrugated cardboard in properties of polypropylene composites: Study of mechanical properties,thermal behavior,and morphological properties

The investigation of the economical use of lignocellulose waste, which is one of the environmental problems facing nations, is ongoing. In this study, waste cardboard paper fiber reinforcing polypropylene (PP) composites was developed. In order to modify the PP matrix maleated PP (MA‐g‐PP) a 5 wt% and a grafting rate of 1 and 2 wt% was used as a compatibilizer. The effects of fiber and compatibilizer content as well as graft content are evaluated by mechanical, thermal property measurements, and scanning electron microscopy (SEM). The compatibilizer improved all mechanical properties significantly. Thus, the tensile strength of MA‐g‐PP‐containing composites increases compared to PP/cardboard composites paper content increases. However, the tensile modulus of a PP‐based composite increases with an increase in paper fiber with the compatibilizer having little effect. SEM revealed that the addition of MA‐g‐PP generates strong interactions between a PP matrix and paper fibers. However, the addition of the MA‐g‐PP compatibilizing agent gives a significant improvement on the crystallization of the composites, whereas the compatibilized PP/old corrugated cardboard (OCC) composites have higher crystallinity (Xc) than uncompatibilized PP/OCC composites. The MA‐g‐PP also diminished the water absorption in the composites. J. VINYL ADDIT. TECHNOL., 22:231–238, 2016. © 2014 Society of Plastics Engineers     

Dispersion of chiral amino acid organomodified Cloisite Na in poly(vinyl alcohol) matrix for designing of novel bionanocomposite films

In this study the inorganic nanolayers of Cloisite Na⁺ was modified with ammonium salt of l-valine amino acid (Val) and then it was dispersed in poly(vinyl alcohol) (PVA) matrix. The PVA/Cloisite Na⁺/Val bionanocomposites (BNC)s were prepared by solution intercalation technique using ultrasonic irradiation. The reaction between this novel organically modified Cloisite Na⁺ and PVA occurred by the hydrogen bonding and hydrophobic interactions. The basal spacing of the Cloisite Na⁺/Val was studied by X-ray diffraction. The thermal stability and optical clarity of PVA and PVA/Cloisite Na⁺/Val are also studied by thermogravimetric analysis (TGA) and UV–visible transmission spectra, respectively. TGA results show that using Cloisite Na⁺/Val in the PVA matrix improved the thermal stability property of the resulting BNC films. The morphological image of synthesized materials was studied by scanning electron microscopy, and transmission electron microscopy. The nanocomposite structure study specified a coexistence of exfoliated and intercalated Cloisite Na⁺/Val layers in the PVA matrix.     

Plastic-containing materials as alternative reductants for base metal production

Shredder residue materials are produced after the removal of ferrous and non-ferrous fractions from end-of-life electronic equipment. Despite the high plastic content and metal value in the ash, high percentages of these materials are currently sent to landfills. In this study, the potential of utilising shredder residue material and other plastic-containing materials as reducing agents was studied. Plastic-containing materials were co-injected with coal into a zinc-fuming furnace in Boliden-Rönnskär smelter. The data obtained from the trial, such as the data from the chemical analysis of the slag and the steam production, are discussed. The observations indicate that plastic-containing material can replace up to 1?ton?h^?1 of coal without a significant decrease in the zinc reduction rate.     

A new quantum-dot cellular automata full-adder

A novel expandable five-input majority gate for quantum-dot cellular automata and a new full-adder cell are presented. Quantum-dot cellular automata (QCA) is an emerging technology and a possible alternative for semiconductor transistor based technologies. A novel QCA majority-logic gate is proposed. This component is suitable for designing QCA circuits. The gate is simple in structure and powerful in terms of implementing digital functions. By applying these kinds of gates, the hardware requirement for a QCA design can be reduced and circuits can be simpler in level, gate counts and clock phases. In order to verify the functionality of the proposed device, some physical proofs are provided. The proper functionality of the FA is checked by means of computer simulations using QCADesigner tool. Both simulation results and physical relations confirm our claims and its usefulness in designing every digital circuit.     

Rheological properties of biopolymers drilling fluids

Drilling muds are complex fluids, generally used to clean the well, maintain hole integrity, transport the rock cuttings, lubricate the drill bit and control formation pressures. Two basic types of drilling fluids are used, water based muds (WBM) and oil based muds (OBM). OBM are very effective but polluting, and environmental regulations continue to restrict the use of oil based muds in many areas of the world. In order to reduce the mud toxicity, we developed water based mud systems using two biopolymers, which are xanthan gum and scleroglucan, generally proposed for high permeability reservoirs or for complex geometries such as horizontal wells. In this study, we evaluated the rheological behaviour of different samples and we determined the effect of components such as clay, calcium carbonate and potassium chloride. This formulations exhibit non-Newtonian rheological behaviour which can be described well by the tree parameter in Herschel–Bulkley rheological model.     

Polyester condensation adducts as novel photo stabilizers for polystyrene

Polycondensation adducts formed by the reaction of maleic anhydride with some Polyalcohols, namely, phloroglucinol, glycerol, and ethylene glycol, were prepared, characterized, and investigated as photostabilizers for polystyrene. Their Photostabilizing effectiveness was evaluated by measuring the extent of weight loss (%), the amount of gel formed as well as the viscosity average molecular weight of the soluble fractions of the degraded polymer. The results indicated better stabilizing effects of these stabilizers compared with that of the UV absorber, phenyl salicylate. A synergistic effect was achieved when the investigated photostabilizers were mixed with phenyl salicylate in a weight ratio of 1 : 1, and a radical mechanism is proposed to account for the action of the polycondensation adducts as photostabilizers. J. VINYL ADDIT. TECHNOL., 19:293–301, 2013. © 2013 Society of Plastics Engineers     

Biomarkers of meat tenderness: Present knowledge and perspectives in regards to our current understanding of the mechanisms involved

Biomarkers of the meat quality are of prime importance for meat industry, which has to satisfy consumers' expectations and, for them, meat tenderness is and will remain the primary and most important quality attribute. The tenderization of meat starts immediately after animal death with the onset of apoptosis followed by a cooperative action of endogenous proteolytic systems. Before consideration of the biomarkers identified so far, we present here some new features on the apoptotic process. Among them, the most important is the recent discovery of a complex family of serpins capable to inhibit, in a pseudo-irreversible manner, caspases, the major enzymes responsible of cell dismantling during apoptosis. The biomarkers so far identified have been then sorted and grouped according to their common biological functions. All of them refer to a series of biological pathways including glycolytic and oxidative energy production, cell detoxification, protease inhibition and production of Heat Shock Proteins. Some unusual biomarkers are also presented: annexins, galectins and peroxiredoxins. On this basis, a detailed analysis of these metabolic pathways allowed us to identify some domains of interest for future investigations. It was thus emphasized that mitochondria, an important organelle in the production of energy from carbohydrates, lipids and proteins are a central element in the initiation and development of apoptosis. It was therefore stressed forward that, in fact, very little is known about the postmortem fate of these organelles and their multiple associated activities. Other topics discussed here would provide avenues for the future in the context of identifying reliable predictors of the ultimate meat tenderness.