含七氟异丙基的苯胺类化合物的合成

以连二亚硫酸钠为引发剂,在苯环上通过自由基亲电取代反应引入七氟异丙基,合成了一系列含七氟异丙基的苯胺类衍生物,研究了各种条件对反应的速度和收率的影响。最佳结果为:芳胺与七氟异丙基碘的物质的量比1:1.1～1.5,连二亚硫酸钠、碳酸氢钠与苯胺的物质的量分别为1.1～1.3,相转移催化剂四丁基溴化铵与苯胺的物质的量比在0.05～0.1,溶剂总用量使苯胺浓度在0.5～1.0mol/L;反应温度10～20℃;溶剂采用乙醚。取代基供电子性越强,反应时间越短,产率越高;氨基的对位优先反应,氨基的邻位较难发生反应;且七氟异丙基总是优先取代在芳环电子云密度较高的位置上。     

加强消防法制建设 构建依法治火体系的思考

消防法制建设是增强消防工作规范性的关键,有利于在相关法律法规的引导下优化依法治火体系,实现对火灾隐患的全面排查,满足社会生产生活需求。消防法制建设也是依法治国战略实施中的关键内容,顺应当前消防工作的发展趋势,促进社会经济的稳定发展。然而,在实践工作中也面临着一定的挑战,导致依法治火体系建设的阻力增大。文章将对消防法制建设的特点进行分析,明确加强消防法制建设构建依法治火体系的重要性,提出消防法制建设和依法治火体系构建中的问题,并提出相应的解决对策,为实践工作提供参考。     

电力系统中无触点有载调压装置的研究与应用

随着科技和经济的发展,大量用电设备对供电质量的要求越来越高,传统的有载调压变压器由于其固有的缺陷而不能满足要求。现有的通过继电器切换或炭刷来调节电压的交流稳压器通常用在低压用户端,而且也存在一些弊端。目前正研究的无触点有载调压变压器,由于晶闸管是直接用于主电路,因此需要大量的晶闸管串并联,控制复杂,体积大,价格高,并且技术也未成熟,并没有推向市场。基于此,本文提出了一种配电系统的无触点有载调压拓扑结构,它具有上述装置的优点,同时又克服了其缺点。本文除了对其工作原理,主电路进行了介绍外,还重点对暂态无冲击控制条件进行了分析,最后通过实验对该设备进行了验证。     

电力变压器经济运行研究

变压器参数是研究变压器经济运行的基础,运用最小二乘法对变压器参数进行校验并采用VB语言编制相应的软件,实例表明该校验方法对变压器经济运行计算是必要的,实用的。     

Analysis of miRNA Expression Profiling of RIP2 Knockdown in Chicken HD11 Cells When Infected with Avian Pathogenic E. coli (APEC)

Colibacillosis is an acute and chronic avian disease caused by avian pathogenic E. coli (APEC). Previous studies have demonstrated that RIP2 plays a significant role in APEC infection. Moreover, increasing evidence indicates that microRNAs (miRNAs) are involved in host–pathogen interactions and the immune response. However, the role of miRNAs in the host against APEC infection remains unclear. Herein, we attempted to reveal new miRNAs potentially involved in the regulation of the immune and inflammatory response against APEC infection, with a particular focus on those possibly correlated with RIP2 expression, via miRNA-seq, RT-qPCR, Western blotting, dual-luciferase reporter assay, and CCK-8. The results showed that a total of 93 and 148 differentially expressed (DE) miRNAs were identified in the knockdown of RIP2 cells following APEC infection (shRIP2+APEC) vs. knockdown of RIP2 cells (shRIP2) and shRIP2 vs. wild-type cells (WT), respectively. Among those identified DE miRNAs, the biological function of gga-miR-455-5p was investigated. It was found that gga-miR-455-5p regulated by RIP2 was involved in the immune and inflammatory response against APEC infection via targeting of IRF2 to modulate the expression of type I interferons. Additionally, RIP2 could directly regulate the production of the type I interferons. Altogether, these findings highlighted the crucial role of miRNAs, especially gga-miR-455-5p, in host defense against APEC infection.     

Wire-in-Wire TiO2/C Nanofibers Free-Standing Anodes for Li-Ion and K-Ion Batteries with Long Cycling Stability and High Capacity

Wearable and portable mobile phones play a critical role in the market,and one of the key technologies is the flexible electrode with high spe-cific capacity an...     

皮带布料机在龙滩大坝碾压混凝土施工中的应用

以美国ROTEC公司的塔带机、供料线为代表的皮带布料机已成功应用于三峡工程常态混凝土浇筑,而用于大坝主体工程碾压混凝土浇筑是个新事物;碾压混凝土施工具有连续、快速、高强度的特点,势必要求混凝土输送各个环节与之匹配、相适应。从拌和楼放料、供料线接料设计、供料线保温、塔（顶）带机仓面布料等方面入手对皮带布料机进行了分析,总结了皮带布料机在浇筑碾压混凝土施工中的经验。     

Effects of Ferroptosis on Male Reproduction

Ferroptosis is a relatively novel form of regulated cell death that was discovered in 2012. With the increasing research related to the mechanisms of ferroptosis, previous studies have demonstrated that the inactive of the intracellular antioxidant system and iron overload can result in the accumulation of reactive oxygen species (ROS), which can ultimately cause lipid peroxidation in the various cell types of the body. ROS accumulation can cause sperm damage by attacking the plasma membrane and damaging DNA. Acute ferroptosis causes oxidative damage to sperm DNA and testicular oxidative stress, thereby causing male reproductive dysfunction. This review aims to discuss the metabolic network of ferroptosis, summarize and analyze the relationship between male reproductive diseases caused by iron overload as well as lipid peroxidation, and provide a novel direction for the research and prevention of various male reproductive diseases.     

拉西瓦水电站高地应力区特大地下厂房开挖施工技术

拉西瓦水电站地下厂房厂区地应力高、地质条件较复杂,特大厂房与众多洞室的立体交叉,增加了厂房特别是高边墙的施工难度,围岩稳定和快速施工是本工程的难点和重点。该地下厂房的施工方法、施工程序、爆破参数,可为以后同类工程施工提供一定的经验和借鉴。     

BOPP薄膜市场现状及发展趋势

介绍了我国双向拉伸聚丙烯薄膜的市场现状,并对其发展趋势进行了展望。