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排序方式: 共有143条查询结果,搜索用时 15 毫秒
71.
Dr. Lluís Ballell Dr. Robert H. Bates Dr. Rob J. Young Daniel Alvarez‐Gomez Dr. Emilio Alvarez‐Ruiz Vanessa Barroso Delia Blanco Benigno Crespo Dr. Jaime Escribano Rubén González Sonia Lozano Dr. Sophie Huss Angel Santos‐Villarejo Dr. José Julio Martín‐Plaza Dr. Alfonso Mendoza Dr. María José Rebollo‐Lopez Dr. Modesto Remuiñan‐Blanco Dr. José Luis Lavandera Dr. Esther Pérez‐Herran Dr. Francisco Javier Gamo‐Benito Dr. José Francisco García‐Bustos Dr. David Barros Dr. Julia P. Castro Dr. Nicholas Cammack 《ChemMedChem》2013,8(2):313-321
With the aim of fuelling open‐source, translational, early‐stage drug discovery activities, the results of the recently completed antimycobacterial phenotypic screening campaign against Mycobacterium bovis BCG with hit confirmation in M. tuberculosis H37Rv were made publicly accessible. A set of 177 potent non‐cytotoxic H37Rv hits was identified and will be made available to maximize the potential impact of the compounds toward a chemical genetics/proteomics exercise, while at the same time providing a plethora of potential starting points for new synthetic lead‐generation activities. Two additional drug‐discovery‐relevant datasets are included: a) a drug‐like property analysis reflecting the latest lead‐like guidelines and b) an early lead‐generation package of the most promising hits within the clusters identified. 相似文献
72.
Josep Lluís Mateo 《Architectural Design》2012,82(6):46-51
In historic towns and villages, topography layered by the detritus of previous structures mark out and continue to inform the identity and design of new buildings and streets. Spanish architect Josep Lluís Mateo describes two projects in his native Catalonia – one from the early 1980s for the redevelopment the medieval town of Ullastret, near Girona, and another from 2011 for a film theatre in Barcelona – that were influenced from the bottom up by the earth beneath his feet. 相似文献
73.
Fernández P Carrera G Grimalt JO Ventura M Camarero L Catalan J Nickus U Thies H Psenner R 《Environmental science & technology》2003,37(15):3261-3267
Polycyclic aromatic hydrocarbons (PAH) were measured in bulk atmospheric deposition collected in three remote areas of Europe during 1997-1998. Mean total PAH fluxes over a period of 18 months were 1560 +/- 750 and 1150 +/- 630 ng m(-2) mo(-1) in the Pyrenees and the Alps, respectively. In the Caledonian mountains (Scandinavia) the observed mean fluxes were 1900 +/- 940 ng m(-2) mo(-1) (6 month collection). Similar qualitative PAH compositions (p values <0.05) in the bulk atmospheric deposition have been observed between sites, which are dominated by the more volatile parent compounds. The main differences between lakes are related to the high molecular weight compounds. Atmospheric deposition of PAH to these remote sites appears to be independent of their concentrations in the atmosphere, which are similar between sites (in the range of 1.8-3.0 ng x m(-3)), being controlled mainly by particle deposition, followed by precipitation and air temperature. A multilevel regression model including these three variables accounted for 74% of the total variability in total PAH bulk deposition; however, the contribution of each variable in the model is compound and site-dependent. The deposition of high molecular weight PAH depends more on particle deposition and precipitation, whereas air temperature is the main factor controlling the deposition fluxes of the low molecular weight PAH. 相似文献
74.
Vega Pérez-Gracia Daniel Di Capua Ramón González-Drigo Lluís Pujades 《NDT & E International》2009,42(4):336-344
High-resolution ground-penetrating radar (GPR) evaluations of structures are usually carried out using antennas with high nominal centre frequencies (between 1 and 2 GHz). A comprehensive characterization of such an antenna would make it possible to determine the capabilities of a system and obtain accurate data interpretations. This paper describes the experimental determination of the radiation pattern of a commercial 1.6 GHz antenna, which forms part of a comprehensive experimental characterization. Radiation patterns are closely related to spatial resolution, so the horizontal and vertical resolutions are evaluated first. The footprint of the antenna is then measured in air using simple devices at different distances. The final result is the approximate spatial radiation pattern of the emitted energy, measured in air. Finally, these measurements are also taken in sand to obtain the radiation pattern and footprint of the antenna in this medium. 相似文献
75.
Sara Fontdecaba Pere Grima Lluís Marco Lourdes Rodero José A. Sánchez-Espigares Ignasi Solé Xavier Tort-Martorell Dominique Demessence Victor Martínez De Pablo Jordi Zubelzu 《Water Resources Management》2012,26(2):499-516
Water management has become a vital concern for both water supply companies and public administrations due to the importance
of water for life and current scarcity in many areas. Studies exist that attempt to explain which factors influence water
demand. In general, these studies are based on a small sample of consumers and they predict domestic water consumption using
ordinary least squares regression models with a small number of socioeconomic variables as predictors, usually: price, population,
population density, age, and nationality. We have followed a different approach in two ways; one, in the scope of the study:
we have included in the study all consumers of the Barcelona area and as many socioeconomic variables as possible (all the
available data from official statistics institutions); and also in the methodology: first, we have segmented clients into
homogeneous socioeconomic groups that, as we show later in the Barcelona case, also have homogeneous water consumption habits.
This allows for a better understanding of water consumption behaviours and also for better predictions through modeling water
consumption in each segment. This is so because the segments’ inner variability is smaller than the general one; thus, the
models have a smaller residual variance and allow for more accurate forecasts of water consumption. The methodology was applied
to the Barcelona metropolitan area, where it was possible to construct a database including both water consumption and socioeconomic
information with more than one million observations. Data quality was a primary concern, and thus a careful exploratory data
analysis procedure led to a careful treatment of missing observations and to the detection and correction or removal of anomalies.
This has resulted in a stable division of the one million water consumers into 6 homogeneous groups and models for each of
the groups. Although the methodology has been developed and applied to the Barcelona area, it is general and thus can be applied
to any other region or metropolitan area. 相似文献
76.
介绍鞍钢半连轧1780轧机基础混凝土施工中应用的新技术,包括BW-Ⅱ橡胶止水条,短角钢熔槽帮条焊技术及后落带的施工,并对大体积混凝土的养护提出几点看法。 相似文献
77.
Dietary proanthocyanidins modulate melatonin levels in plasma and the expression pattern of clock genes in the hypothalamus of rats 下载免费PDF全文
78.
In this research note, we introduce a graded BDI agent development framework, g-BDI for short, that allows to build agents as multi-context systems that reason about three fundamental and graded mental attitudes (i.e. beliefs, desires and intentions). We propose a sound and complete logical framework for them and some logical extensions to accommodate slightly different views on desires. 相似文献
79.
Resveratrol Potently Counteracts Quercetin Starvation‐Induced Autophagy and Sensitizes HepG2 Cancer Cells to Apoptosis 下载免费PDF全文