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31.
    
Alzheimer’s disease (AD) is a progressive condition and the most common cause of dementia worldwide. The neuropathological changes characteristic of the disorder can be successfully detected before the development of full-blown AD. Early diagnosis of the disease constitutes a formidable challenge for clinicians. CSF biomarkers are the in vivo evidence of neuropathological changes developing in the brain of dementia patients. Therefore, measurement of their concentrations allows for improved accuracy of clinical diagnosis. Moreover, AD biomarkers may provide an indication of disease stage. Importantly, the CSF biomarkers of AD play a pivotal role in the new diagnostic criteria for the disease, and in the recent biological definition of AD by the National Institute on Aging, NIH and Alzheimer’s Association. Due to the necessity of collecting CSF by lumbar puncture, the procedure seems to be an important issue not only from a medical, but also a legal, viewpoint. Furthermore, recent technological advances may contribute to the automation of AD biomarkers measurement and may result in the establishment of unified cut-off values and reference limits. Moreover, a group of international experts in the field of AD biomarkers have developed a consensus and guidelines on the interpretation of CSF biomarkers in the context of AD diagnosis. Thus, technological advancement and expert recommendations may contribute to a more widespread use of these diagnostic tests in clinical practice to support a diagnosis of mild cognitive impairment (MCI) or dementia due to AD. This review article presents up-to-date data regarding the usefulness of CSF biomarkers in routine clinical practice and in biomarkers research.  相似文献   
32.
    
The human body’s natural protective barrier, the skin, is exposed daily to minor or major mechanical trauma, which can compromise its integrity. Therefore, the search for new dressing materials that can offer new functionalisation is fully justified. In this work, the development of two new types of dressings based on poly(3-hydroxyoctanoate) (P(3HO)) is presented. One of the groups was supplemented with conjugates of an anti-inflammatory substance (diclofenac) that was covalently linked to oligomers of hydroxycarboxylic acids (Oli-dicP(3HO)). The novel dressings were prepared using the solvent casting/particulate leaching technique. To our knowledge, this is the first paper in which P(3HO)-based dressings were used in mice wound treatment. The results of our research confirm that dressings based on P(3HO) are safe, do not induce an inflammatory response, reduce the expression of pro-inflammatory cytokines, provide adequate wound moisture, support angiogenesis, and, thanks to their hydrophobic characteristics, provide an ideal protective barrier. Newly designed dressings containing Oli-dicP(3HO) can promote tissue regeneration by partially reducing the inflammation at the injury site. To conclude, the presented materials might be potential candidates as excellent dressings for wound treatment.  相似文献   
33.
    
Quercetin, classified as a flavonoid, is a strong antioxidant that plays a significant role in the regulation of physiological processes in plants, which is particularly important in the case of biotic and abiotic stresses. The study investigated the effect of the use of potassium quercetin solutions in various concentrations (0.5%, 1.0%, 3.0% and 5.0%) on the physiological and biochemical properties of wheat seedlings. A pot experiment was carried out in order to determine the most beneficial dose of this flavonoid acting as a bio-stimulant for wheat plants. Spraying with quercetin derivative solutions was performed twice, and physiological measurements (chlorophyll content and fluorescence as well as gas exchange) were carried out on the first and seventh days after each application. The total phenolic compounds content and the total antioxidant capacity were also determined. It was shown that the concentrations of potassium quercetin applied have a stimulating effect on the course of physiological processes. In the case of most of the tested physiological parameters (chlorophyll content and fluorescence and gas exchange) and the total antioxidant capacity, no significant differences were observed in their increase as a result of application with concentrations of 3.0 and 5.0%. Therefore, the beneficial effect of quercetin on the analysed parameters is already observed when spraying with a concentration of 3.0%.  相似文献   
34.
    
Tendinopathies are painful, disabling conditions that afflict 25% of the adult human population. Filling an unmet need for realistic large-animal models, we here present an ovine model of tendon injury for the comparative study of adult scarring repair and fetal regeneration. Complete regeneration of the fetal tendon within 28 days is demonstrated, while adult tendon defects remained macroscopically and histologically evident five months post-injury. In addition to a comprehensive histological assessment, proteome analyses of secretomes were performed. Confirming histological data, a specific and pronounced inflammation accompanied by activation of neutrophils in adult tendon defects was observed, corroborated by the significant up-regulation of pro-inflammatory factors, neutrophil attracting chemokines, the release of potentially tissue-damaging antimicrobial and extracellular matrix-degrading enzymes, and a response to oxidative stress. In contrast, secreted proteins of injured fetal tendons included proteins initiating the resolution of inflammation or promoting functional extracellular matrix production. These results demonstrate the power and relevance of our novel ovine fetal tendon regeneration model, which thus promises to accelerate research in the field. First insights from the model already support our molecular understanding of successful fetal tendon healing processes and may guide improved therapeutic strategies.  相似文献   
35.
    
Theophylline, a typical representative of active pharmaceutical ingredients, was selected to study the characteristics of experimental and theoretical solubility measured at 25 °C in a broad range of solvents, including neat, binary mixtures and ternary natural deep eutectics (NADES) prepared with choline chloride, polyols and water. There was a strong synergistic effect of organic solvents mixed with water, and among the experimentally studied binary systems, the one containing DMSO with water in unimolar proportions was found to be the most effective in theophylline dissolution. Likewise, for NADES, the addition of water (0.2 molar fraction) resulted in increased solubility compared to pure eutectics, with the highest solubilisation potential offered by the composition of choline chloride with glycerol. The ensemble of Statistica Automated Neural Networks (SANNs) developed using intermolecular interactions in pure systems has been found to be a very accurate model for solubility computations. This machine learning protocol was also applied as an extensive screening for potential solvents with higher solubility of theophylline. Such solvents were identified in all three subgroups, including neat solvents, binary mixtures and ternary NADES systems. Some methodological considerations of SANNs applications for future modelling were also provided. Although the developed protocol is focused exclusively on theophylline solubility, it also has general importance and can be used for the development of predictive models adequate for solvent screening of other compounds in a variety of systems. Formulation of such a model offers rational guidance for the selection of proper candidates as solubilisers in the designed solvents screening.  相似文献   
36.
    
Atherosclerosis and nonalcoholic fatty liver disease are leading causes of morbidity and mortality in the Western countries. The renin–angiotensin system (RAS) with its two main opposing effectors, i.e., angiotensin II (Ang II) and Ang-(1–7), is widely recognized as a major regulator of cardiovascular function and body metabolic processes. Angiotensin-converting enzyme 2 (ACE2) by breaking-down Ang II forms Ang-(1–7) and thus favors Ang-(1–7) actions. Therefore, the aim of our study was to comprehensively evaluate the influence of prolonged treatment with ACE2 activator, diminazene aceturate (DIZE) on the development of atherosclerotic lesions and hepatic steatosis in apoE−/− mice fed a high-fat diet (HFD). We have shown that DIZE stabilized atherosclerotic lesions and attenuated hepatic steatosis in apoE−/− mice fed an HFD. Such effects were associated with decreased total macrophages content and increased α-smooth muscle actin levels in atherosclerotic plaques. Moreover, DIZE changed polarization of macrophages towards increased amount of anti-inflammatory M2 macrophages in the atherosclerotic lesions. Interestingly, the anti-steatotic action of DIZE in the liver was related to the elevated levels of HDL in the plasma, decreased levels of triglycerides, and increased biosynthesis and concentration of taurine in the liver of apoE−/− mice. However, exact molecular mechanisms of both anti-atherosclerotic and anti-steatotic actions of DIZE require further investigations.  相似文献   
37.
    
Considering the advent of antibiotic resistance, the study of bacterial metabolic behavior stimulated by novel antimicrobial agents becomes a relevant tool to elucidate involved adaptive pathways. Profiling of volatile metabolites was performed to monitor alterations of bacterial metabolism induced by biosynthesized silver nanoparticles (bio-AgNPs). Escherichia coli, Enterococcus faecalis, Klebsiella pneumoniae and Proteus mirabilis were isolated from pressure ulcers, and their cultures were prepared in the presence/absence of bio-AgNPs at 12.5, 25 and 50 µg mL−1. Headspace solid phase microextraction associated to gas chromatography–mass spectrometry was the employed analytical platform. At the lower concentration level, the agent promoted positive modulation of products of fermentation routes and bioactive volatiles, indicating an attempt of bacteria to adapt to an ongoing suppression of cellular respiration. Augmented response of aldehydes and other possible products of lipid oxidative cleavage was noticed for increasing levels of bio-AgNPs. The greatest concentration of agent caused a reduction of 44 to 80% in the variety of compounds found in the control samples. Pathway analysis indicated overall inhibition of amino acids and fatty acids routes. The present assessment may provide a deeper understanding of molecular mechanisms of bio-AgNPs and how the metabolic response of bacteria is untangled.  相似文献   
38.
Mobile devices with 3G/4G networking often waste energy in the so-called “tail time” during which the radio is kept on even though no communication is occurring. Prior work has proposed policies to reduce this energy waste by batching network requests. However, this work is challenging to apply in practice due to a lack of mechanisms. In response, we have developed DelayDroid, a framework that allows a developer to add the needed policy to existing, unmodified Android applications (apps) with no human effort as well as no SDK/OS changes. This allows such prior work (as well as our own policies) to be readily deployed and evaluated. The DelayDroid compile-time uses static analysis and bytecode refactoring to identify method calls that send network requests and modify such calls to detour them to the DelayDroid run-time. The run-time then applies a policy to batch them, avoiding the tail time energy waste. DelayDroid also includes a cross-app communication mechanism that supports policies that optimize across multiple apps running together, and we propose a policy that does so. We evaluated the correctness and universality of the DelayDroid mechanisms on 14 popular Android apps chosen from the Google App Store. To evaluate our proposed policy, we studied three DelayDroid-enabled apps (weather forecasting, email client, and news client) running together, finding that the DelayDroid mechanisms combined with our policy can reduce 3G/4G tail time energy waste by 36%.  相似文献   
39.
The visual richness of computer graphics applications is frequently limited by the difficulty of obtaining high‐quality, detailed 3D models. This paper proposes a method for realistically transferring details (specifically, displacement maps) from existing high‐quality 3D models to simple shapes that may be created with easy‐to‐learn modeling tools. Our key insight is to use metric learning to find a combination of geometric features that successfully predicts detail‐map similarities on the source mesh; we use the learned feature combination to drive the detail transfer. The latter uses a variant of multi‐resolution non‐parametric texture synthesis, augmented by a high‐frequency detail transfer step in texture space. We demonstrate that our technique can successfully transfer details among a variety of shapes including furniture and clothing.  相似文献   
40.
While the experimental detection of entanglement provides already quite a difficult task, experimental quantification of entanglement is even more challenging, and has not yet been studied thoroughly. In this paper we discuss several issues concerning bounds on concurrence measurable collectively on copies of a given quantum state. Firstly, we concentrate on the recent bound on concurrence by (Mintert and Buchleitner in Phys Rev Lett 98:140505/1–140505/4, 2007). Relating it to the reduction criterion for separability we provide yet another proof of the bound and point out some possibilities following from the proof which could lead to improvement of the bound. Then, relating concurrence to the generalized robustness of entanglement, we provide a method allowing for construction of lower bounds on concurrence from any positive map (not only the reduction one). All these quantities can be measured as mean values of some two-copy observables. In this sense the method generalizes the Mintert–Buchleitner bound and recovers it when the reduction map is used. As a particular case we investigate the bound obtained from the transposition map. Interestingly, comparison with MB bound performed on the class of ${4\otimes 4}While the experimental detection of entanglement provides already quite a difficult task, experimental quantification of entanglement is even more challenging, and has not yet been studied thoroughly. In this paper we discuss several issues concerning bounds on concurrence measurable collectively on copies of a given quantum state. Firstly, we concentrate on the recent bound on concurrence by (Mintert and Buchleitner in Phys Rev Lett 98:140505/1–140505/4, 2007). Relating it to the reduction criterion for separability we provide yet another proof of the bound and point out some possibilities following from the proof which could lead to improvement of the bound. Then, relating concurrence to the generalized robustness of entanglement, we provide a method allowing for construction of lower bounds on concurrence from any positive map (not only the reduction one). All these quantities can be measured as mean values of some two-copy observables. In this sense the method generalizes the Mintert–Buchleitner bound and recovers it when the reduction map is used. As a particular case we investigate the bound obtained from the transposition map. Interestingly, comparison with MB bound performed on the class of 4?4{4\otimes 4} rotationally invariant states shows that the new bound is positive in regions in which the MB bound gives zero. Finally, we provide measurable upper bounds on the whole class of concurrences.  相似文献   
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