Insulin resistance in cancer patients is associated with enhanced tumor necrosis factor-alpha expression in skeletal muscle

The roles of tumor necrosis factor (TNF)-alpha and the facilitative glucose transporter (GLUT) 4 on the induction of insulin resistance in peripheral tissues of cancer patients was examined by quantitative competitive PCR on biopsies of abdominal rectal muscle from patients with gastrointestinal cancer. The degree of insulin resistance in these patients was measured by the euglycemic hyperinsulinemic glucose clamp using a high physiologic insulin concentration (100 microU/ml). Quantitative competitive PCR was carried out using DNA competitors constructed by deleting 20-30 bp between the two primer annealing sites. Decreased glucose uptake (M value) in peripheral tissues was accompanied by a significantly increased TNF-alpha mRNA in skeletal muscle (r=0.867, p=0.0025). GLUT4 mRNA, however, was positively correlated with M values (r=0.739, p=0.015). The amounts of mRNAs for TNF-alpha and GLUT4 in skeletal muscle were not correlated. Serum TNF-alpha concentrations remained below the limit of detection. These findings suggest that the insulin resistance in peripheral tissues of cancer patients is in part due to the induction TNF-alpha mRNA and the down regulation of GLUT4 mRNA in peripheral tissues.     

Systematic Evaluation of Construction Equipment Alternatives: Case Study

Selecting the right equipment for the project is inherently a multifaceted cost and benefit evaluation process that is further compounded by the complexity of today’s building projects and the lack of systematic tools for the consideration of soft factors. This paper presents a detailed application example of a model based on an analytical hierarchy process (AHP) approach. This model was developed to address the difficulties experienced during the multifaceted process. The example illustrates how an AHP-based model helps address the multitude of qualitative, intangible factors, both among the factors themselves and then vis-à-vis costs, by means of a systematic and traceable process. The method enables project managers and their equipment selection teams to exercise their knowledge, intuition, and professional judgment, and at the same time to address the context and specifics of the particular projects under examination. The example should be helpful for construction practitioners dealing with similar equipment selection issues. Researchers may find interest in the implementation of a multiattribute-decision-making method for a typical construction management problem.     

Random model sampling: Making craig interpolation work when it should not

One of the most serious problems when doing program analyses is dealing with function calls. While function inlining is the traditional approach to this problem, it nonetheless suffers from the increase in analysis complexity due to the state space explosion. Craig interpolation has been successfully used in recent years in the context of bounded model checking to do function summarization which allows one to replace the complete function body with its succinct summary and, therefore, reduce the complexity, but unfortunately this technique can be applied only to a pair of unsatisfiable formulae. In this work-in-progress paper we present an approach to function summarization based on Craig interpolation that overcomes its limitation by using random model sampling. It captures interesting input/output relations, strengthening satisfiable formulae into unsatisfiable ones and thus allowing the use of Craig interpolation. Evaluation results show the applicability of this approach; in our future work we plan to do a more extensive evaluation on real-world examples.     

Fiber Bragg grating (FBG) characterization and shaping by localpressure

The spatial distribution of the chirp profile of a 4-cm-long nonuniform fiber Bragg grating (FBG) was studied with the exertion of local pressure on the fiber through the application of transverse force to a small grating section (~0.3 mm). The technique was also used for spectrally shaping a previously unchirped, 18-cm-long Bragg grating, generating a narrow transmission window (~400 MHz) inside its reflective band. A physical model was developed in order to estimate the phase shifts induced by pressure. A numerical simulation based on the piecewise-uniform approach was also used to calculate the consequent changes in reflected spectrum. Experimental and theoretical data show good agreement and the pressure technique proved to be adequate for grating characterization and spectral shaping     

Refractories for shielding thermocouples when measuring high temperatures

Conclusions Tips made of MgO can operate in argon at 2400°C for up to 5 h.Tips of ZrO₂ are suitable for measuring temperatures up to 2400°C for several minutes and for longer periods up to 1900°C both in vacuum and in atmospheres of nitrogen and argon.Long tips should be fitted to graphite rods.     

Room-temperature ionic liquids: slow dynamics, viscosity, and the red edge effect

Ionic liquids (ILs) have recently attracted significant attention from academic and industrial sources. This is because, while their vapor pressures are negligible, many of them are liquids at room temperature and can dissolve a wide range of polar and nonpolar organic and inorganic molecules. In this Account, we discuss the progress of our laboratory in understanding the dynamics, spectroscopy, and fluid dynamics of selected imidazolium-based ILs using computational and analytical tools that we have recently developed. Our results indicate that the red edge effect, the non-Newtonian behavior, and the existence of locally heterogeneous environments on a time scale relevant to chemical and photochemical reactivity are closely linked to the viscosity and highly structured character of these liquids.