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排序方式: 共有1439条查询结果,搜索用时 0 毫秒
81.
Sueva Cantalupo Vito Alessandro Lasorsa Roberta Russo Immacolata Andolfo Giuseppe DAlterio Barbara Eleni Rosato Giulia Frisso Pasquale Abete Gian Marco Cassese Giuseppe Servillo Ivan Gentile Carmelo Piscopo Matteo Della Monica Giuseppe Fiorentino Giuseppe Russo Pellegrino Cerino Carlo Buonerba Biancamaria Pierri Massimo Zollo Achille Iolascon Mario Capasso 《International journal of molecular sciences》2021,22(10)
Genome-wide association studies (GWAS) found locus 3p21.31 associated with severe COVID-19. CCR5 resides at the same locus and, given its known biological role in other infection diseases, we investigated if common noncoding and rare coding variants, affecting CCR5, can predispose to severe COVID-19. We combined single nucleotide polymorphisms (SNPs) that met the suggestive significance level (P ≤ 1 × 10−5) at the 3p21.31 locus in public GWAS datasets (6406 COVID-19 hospitalized patients and 902,088 controls) with gene expression data from 208 lung tissues, Hi-C, and Chip-seq data. Through whole exome sequencing (WES), we explored rare coding variants in 147 severe COVID-19 patients. We identified three SNPs (rs9845542, rs12639314, and rs35951367) associated with severe COVID-19 whose risk alleles correlated with low CCR5 expression in lung tissues. The rs35951367 resided in a CTFC binding site that interacts with CCR5 gene in lung tissues and was confirmed to be associated with severe COVID-19 in two independent datasets. We also identified a rare coding variant (rs34418657) associated with the risk of developing severe COVID-19. Our results suggest a biological role of CCR5 in the progression of COVID-19 as common and rare genetic variants can increase the risk of developing severe COVID-19 by affecting the functions of CCR5. 相似文献
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83.
Enrico Capuzzi Alice Caldiroli Martina Capellazzi Ilaria Tagliabue Matteo Marcatili Fabrizia Colmegna Massimo Clerici Massimiliano Buoli Antonios Dakanalis 《International journal of molecular sciences》2021,22(17)
Esketamine (ESK) has been approved as a rapid-acting intranasal treatment for treatment-resistant depression (TRD). Although existing studies have investigated the efficacy of ESK in the 4-week induction phase, our knowledge about long-term ESK efficacy remains poor. The aim of this systematic review was to summarize the available data on long-term ESK efficacy for TRD. A systematic search was performed including articles in English, up to 31 March 2021. The search found 7 relevant studies, involving 1024 adult TRD patients. Continuing treatment with ESK after the 4-week induction phase may be associated with stable efficacy in relapse prevention among TRD patients. Conversely, the long-term antidepressant effectiveness upon discontinuation of ESK might be limited, although data from three studies had a moderate to high risk of bias. Overall, the results on the effectiveness of this compound in the long term are mixed. According to our findings, ESK treatment should be continued following the induction phase to reach a stable efficacy in relapse prevention, while the long-term antidepressant and anti-suicidal effects of ESK after discontinuation are inconsistent. Currently, the level of proof of ESK efficacy in long-term TRD treatment remains low and more RCTs with larger sample sizes and active comparators are needed. 相似文献
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86.
Michele Dei Nicolò Nizza Massimo Piotto Paolo Bruschi 《Analog Integrated Circuits and Signal Processing》2009,58(1):43-47
A compact voltage controlled CMOS current divider is presented. Differently from previous implementations, exploiting the
MOSFET translinear characteristics in subthreshold region, the proposed circuit is based on devices operating from moderate
to strong inversion. An input current linearity range of nearly a decade is obtained by compensating for the deviations from
the ideal drain current square-law approximation through an original empirical approach. The circuit is suitable for use as
a building block in analog multipliers and for transconductor continuous tuning. The effectiveness of the proposed configuration
is demonstrated by means of electrical simulations, performed on a prototype designed with a commercial process. The robustness
of the linearization algorithm with respect to temperature variations is proven. 相似文献
87.
Massimo Merro 《Information and Computation》2009,207(2):194-208
We propose a process calculus to study the behavioural theory of Mobile Ad Hoc Networks. The operational semantics of our calculus is given both in terms of a Reduction Semantics and in terms of a Labelled Transition Semantics. We prove that the two semantics coincide. The labelled transition system is then used to derive the notions of (weak) simulation and bisimulation for ad hoc networks. The labelled bisimilarity completely characterises reduction barbed congruence, a standard branching-time and contextually-defined program equivalence. We then use our (bi)simulation proof method to formally prove a number of non-trivial properties of ad hoc networks. 相似文献
88.
Roberto Cigliutti Andrea Galtarossa Massimo Giltrelli Daniele Grosso Andrew W.R. Leitch Luca Palmieri Stefano Santoni Luca Schenato David Waswa 《Optical Fiber Technology》2009,15(3):242-250
Polarization Mode Dispersion (PMD) compensation has been a matter of investigation of several papers in literature. The proposed solutions belong basically to two large families: electronic compensators and optical compensators. Both PMD compensator schemes have advantages and disadvantages: electronic PMD compensators are usually simple to include in line-terminal, potentially low-cost, very fast, and FEC compatible but their development is strongly dependent on IC technology capability that at this time allows device developments up to the 10 Gbit/s bit rates area. Furthermore, they are strongly dependent on modulation formats, and they can operate only on a single channel. Conversely, optical compensators are independent of bit rate and modulation format and potentially they can compensate more channels simultaneously; their major drawbacks are the longer response time and the complexity in the feedback signal process within the control algorithm. In this paper we consider an optical Polarization Mode Dispersion Compensator (PMDC) that is simple to realize and easy to include at limited costs in each EDFA module (distributed compensation) as well as a single-stage front-end compensator. Numerical analysis of the PMDC and experimental results confirm the utility of the PMDC proposed and its capability in compensating DGD larger than 20 ps in NRZ and RZ 40 Gbit/s optical systems. 相似文献
89.
Carotenuto R Sabbi G Pappalardo M 《IEEE transactions on ultrasonics, ferroelectrics, and frequency control》2002,49(8):1039-1049
Spatial resolution in modern ultrasound imaging systems is limited by the high cost of large aperture transducer arrays, which require a large number of transducer elements and electronic channels. A new technique to enhance the spatial resolution of pulse-echo imaging systems is presented. The method attempts to build an image that could be obtained with a transducer array aperture larger than that physically available. We consider two images of the same object obtained with two different apertures, the full aperture and a subaperture, of the same transducer. A suitable artificial neural network (ANN) is trained to reproduce the relationship between the image obtained with the transducer full aperture and the image obtained with a subaperture. The inputs of the neural network are portions of the image obtained with the subaperture (low resolution image), and the target outputs are the corresponding portions of the image produced by the full aperture (high resolution image). After the network is trained, it can produce images with almost the same resolution of the full aperture transducer, but using a reduced number of real transducer elements. All computations are carried out on envelope-detected decimated images; for this reason, the computational cost is low and the method is suitable for real-time applications. The proposed method was applied to experimental data obtained with the ultrasound synthetic aperture focusing technique (SAFT), giving quite promising results. Realtime implementation on a modern, full-digital echographic system is currently being developed. 相似文献
90.
Livia D'Apuzzo Massimo Squillante 《Annals of Mathematics and Artificial Intelligence》2002,35(1-4):177-195
Starting by quasilinear means, we propose and analyze functionals that allow to represent the preferences of the decision maker in a more general setting; the preference order in the set of the alternatives depends on the way the functional has been generated. The functionals of this kind enjoy classical properties as independence and dominance principle. Anyway we stress that to make use of a single functional is not sufficient to describe paradoxical situations that arise for istance in the Kahneman and Tversky experiment. 相似文献