On the influence of gamma prime upon machining of advanced nickel based superalloy

Whilst gamma prime (γ′) phase is the strengthening phase in Ni-based superalloys its influence on machining has been seldom investigated. This paper reports for the first time on the effect of γ′ upon machining of Ni-based superalloys when cutting with parameters yielding different cutting temperature intervals which lead to strengthening/softening effects on the workpiece (sub)surface. In-depth XRD, SEM/FIB, EBSD analysis and unique micro-pillar testing in the workpiece superficial layers indicated that with the increase of γ′ fraction the grain plastic deformation significantly decreased, while specific cutting energy can switch from low to high values influenced by the real cutting temperature.     

Experimental investigation of a pulsating heat pipe for hybrid vehicle applications

This paper deals with the experimental results of an unlooped pulsating heat pipe (PHP) developed and tested in an electronic thermal management field with hybrid vehicle applications in mind. The 2.5 mm inner tube diameter device was cooled by an air heat exchanger to replicate the environment of a vehicle.In order to characterize this pulsating heat pipe, four working fluids have been tested. They are acetone, methanol, water, and n-pentane, with applied thermal power ranging from 25 W to 550 W, air temperature ranging from 10 °C to 60 °C and air velocity ranging from 0.25 m s^?1 to 2 m s^?1. Three inclinations have also been tested according to their horizontal positions: +45° (condenser above the evaporator), 0° and ?45° (condenser below the evaporator).Among the different results, some of the most revelatory were obtained with regard to unfavourable inclination (?45°), for which the performances were very interesting considering a terrestrial application. On the other hand, one also observed low temperature limitations for water as a working fluid and degradation of performances for n-pentane tested at 60 °C air temperature. On an overall basis, however, it should be noted that the PHP functioned with high reliability and reproducibility and without any failure during the start-up or working stage.     

Drying nano particles solution on an oscillating tip at an air liquid interface: what we can learn, what we can do

Evaporation of fluid at micro and nanometer scale may be used to self-assemble nanometre-sized particles in suspension. Evaporating process can be used to gently control flow in micro and nanofluidics, thus providing a potential mean to design a fine pattern onto a surface or to functionalize a nanoprobe tip. In this paper, we present an original experimental approach to explore this open and rather virgin domain. We use an oscillating tip at an air liquid interface with a controlled dipping depth of the tip within the range of the micrometer. Also, very small dipping depths of a few ten nanometers were achieved with multi walls carbon nanotubes glued at the tip apex. The liquid is an aqueous solution of functionalized nanoparticles diluted in water. Evaporation of water is the driving force determining the arrangement of nanoparticles on the tip. The results show various nanoparticles deposition patterns, from which the deposits can be classified in two categories. The type of deposit is shown to be strongly dependent on whether or not the triple line is pinned and of the peptide coating of the gold nanoparticle. In order to assess the classification, companion dynamical studies of nanomeniscus and related dissipation processes involved with thinning effects are presented.     

Performance of 60 GHz Virtual Cellular Networks Using Multiple Receiving Antennas

During the past years, research covering propagation, channelcharacterization and wireless systems performance have yield asubstantial knowledge of the 60 GHz channel. The unlicensed 60 GHzfrequency band presents many attractive properties for wirelesscommunications. The environments in which the 60 GHzinfrastructure are to be designed are typically propagation- andcoverage-limited. This paper describes the important factors thatmust be taken into account when designing a wireless local areanetwork (WLAN) architecture operating in this frequency band.Therefore, we motivate the reasons of using distributedtransmitting antennas and multiple receiving antennas (MRA) inorder to mitigate the poor Direction of Arrival (DoA) diversityand to exploit the spatial diversity at the receiver. Such asystem can be considered as a multiple input multiple output(MIMO) system. We investigate the advantages of combining aVirtual Cellular Network (VCN) (using single frequency network anddistributed antennas) and MRA for the downlink. Several ways tocombine the signals with different levels of complexity arepresented. In the most complex case using Singular ValueDecomposition (SVD), it is possible to add coherently thecontribution of each antenna in a virtual cell while retaining thepath diversity inherent to the VCN infrastructure. The schemesyield several advantages: symbol diversity is improved, pathdiversity is still present, antenna gain using multiplebeamformers is increased and the multipath can be reduced. Theconcept is applicable to most types of single frequency networksbut it is especially well appropriate for the 60 GHz VCN/WLANusing orthogonal frequency division multiplexing (OFDM).Simulations give a realistic performance for QPSK, 8-PSK, and16-QAM baseband modulations with a 256-subcarrier OFDM using arate 1/2–convolutional code for a 2 ×2 VCN system.Results show a E_b/N₀ improvement of up to 6.2 dB usingthesingular value decomposition method with 16-QAM compared to thesingle input single output (SISO) coded reference.     

Nebulized Gadolinium‐Based Nanoparticles: A Theranostic Approach for Lung Tumor Imaging and Radiosensitization

Lung cancer is the most common and most fatal cancer worldwide. Thus, improving early diagnosis and therapy is necessary. Previously, gadolinium‐based ultra‐small rigid platforms (USRPs) were developed to serve as multimodal imaging probes and as radiosensitizing agents. In addition, it was demonstrated that USRPs can be detected in the lungs using ultrashort echo‐time magnetic resonance imaging (UTE‐MRI) and fluorescence imaging after intrapulmonary administration in healthy animals. The goal of the present study is to evaluate their theranostic properties in mice with bioluminescent orthotopic lung cancer, after intrapulmonary nebulization or conventional intravenous administration. It is found that lung tumors can be detected non‐invasively using fluorescence tomography or UTE‐MRI after nebulization of USRPs, and this is confirmed by histological analysis of the lung sections. The deposition of USRPs around the tumor nodules is sufficient to generate a radiosensitizing effect when the mice are subjected to a single dose of 10 Gy conventional radiation one day after inhalation (mean survival time of 112 days versus 77 days for irradiated mice without USRPs treatment). No apparent systemic toxicity or induction of inflammation is observed. These results demonstrate the theranostic properties of USRPs for the multimodal detection of lung tumors and improved radiotherapy after nebulization.     

Application of scatterometric porosimetry to characterize porous ultra low-k patterned layers

Porous materials such as ultra low-k dielectrics are commonly used in micro and nano technologies. Since porosity leads to an increased sensitivity of the material to etching and post-etching plasma processes, porosity, pore size and surface modifications need to be assessed during material integration. In this work, the recently developed Scatterometric Porosimetry technique using a porosimetry acquisition coupled with a scatterometric analysis is applied to measure the properties of porous patterned layers. Measurements are performed on specially fabricated gratings after exposure to different plasma treatments. A side-by-side comparison between Ellipsometric Porosimetry and Scatterometric Porosimetry is carried out on different plasma-treated samples and shows a different impact of the plasma processes on patterned materials compared with blanket films. These results highlight the interest of Scatterometric Porosimetry to characterize sidewall damage after each step of the process. It also appears as a good complementary technique to Ellipsometric Porosimetry which only allows quantitative measurements on continuous layers.     

Fate of N-nitrosodimethylamine, trihalomethane and haloacetic acid precursors in tertiary treatment including biofiltration

The presence of disinfection by-products (DBPs) such as trihalomethanes (THMs), haloacetic acids (HAAs) and N-nitrosamines in water is of great concern due to their adverse effects on human health. In this work, the removal of N-nitrosodimethylamine (NDMA), total THM and five HAA precursors from secondary effluent by biological activated carbon (BAC) is investigated at full and pilot scale. In the pilot plant two filter media, sand and granular activated carbon, are tested. In addition, we evaluate the influence of ozonation prior to BAC filtration on its performance. Among the bulk of NDMA precursors, the fate of four pharmaceuticals containing a dimethylamino moiety in the chemical structure are individually investigated. Both NDMA formation potential and each of the studied pharmaceuticals are dramatically reduced by the BAC even in the absence of main ozonation prior to the filtration. The low removal of NDMA precursors at the sand filtration in comparison to the removal of NDMA precursors at the BAC suggests that adsorption may play an important role on the removal of NDMA precursors by BAC. Contrary, the precursors for THM and HAA formation are reduced in both sand filtration and BAC indicating that the precursors for the formation of these DBPs are to some extent biodegradable.     

Fibroblast growth factor-2 has opposite effects on human breast cancer MCF-7 cell growth depending on the activation level of the mitogen-activated protein kinase pathway

In human breast cancer MCF-7 and MCF-7ras cells, we demonstrated that whereas insulin had a mitogenic effect on both cell lines, fibroblast growth factor-2 (FGF-2) had opposite effects, stimulating MCF-7 and inhibiting MCF-7ras cell proliferation. The inhibitory signal induced by FGF-2 was related to sustained mitogen-activated protein kinase (MAPK) activation in MCF-7ras cells, while transient MAPK activation was associated with MCF-7 cell proliferation. FGF-2 was further used in combination with insulin or cAMP. In MCF-7 cells, insulin and cAMP reversed the mitogenic effect of FGF-2. In MCF-7ras cells, insulin did not modify the inhibitory effect of FGF-2, but cAMP markedly enhanced it. These effects were also associated with an increased level and duration of MAPK activation. PD98056 abolished the effect of FGF-2 on DNA synthesis in both cell lines, demonstrating that the dual effect of FGF-2 on cell proliferation is dependent on the activity of the extracellular-signal-regulated kinase 1 and 2 (ERK1/2) signalling pathway.