Porous polymer derived ceramic (PDC)-montmorillonite-H3PMo12O40/SiO2 composite membranes for microbial fuel cell (MFC) application

Ceramic membranes can serve as viable alternatives to the less mechanically stable polymeric membranes utilized in microbial fuel cells (MFCs). In this work, a series of polymer-derived ceramic (PDC) proton exchange composite membranes with large ion exchange capacity (IEC) values, high cation transport numbers, and low oxygen diffusion coefficients have been synthesized at various pyrolysis temperatures using a pressing technique. These materials were composed of a polysiloxane matrix mixed with proton-conducting fillers such as montmorillonite and H₃PMo₁₂O₄₀/SiO₂ at different ratios. By tuning the average pore sizes of the membranes between 0.1 and 1?µm and their hydrophilic/hydrophobic characteristics, the maximum IEC of 0.6072 mequiv/g and cation transport number of 0.6988 were obtained, which is 67% and 72% of polymeric nafion performance, respectively. In addition, the minimal oxygen mass transfer coefficient achieved by this approach was equal to 5.62?×?10^?4 cm/s, which is very close to the commercial nafion membrane value. The fabricated PDC composite membranes meet all the essential criteria required for their use in MFC applications and represent a high potential to overcome limitations of polymeric membrane.     

Erfassen von Ursache-Wirkungs-Beziehungen in Flusslandschaften: Vermittlung von Systemwissen in Schulen als Beitrag für ein nachhaltiges Flussgebietsmanagement

A scientific understanding of the processes at work in river landscapes represents an important basis for including the local populace in effective and sustainable river landscape management. By conveying system-based knowledge to students, these future inhabitants and users of river landscapes will be better able to recognize contexts and connections, understand project-related decisions and policies, and support sustainable planning efforts. As such, in October 2012 the Austrian Federal Ministry for Science and Research started the “FlussAu:WOW!” project, part of the “Sparkling Science” research program. In the project, scientists work together with the students from two upper-level high-school classes over a period of two years, investigating research questions on river landscape management. The scientific goal of the project is to create a set of indicators to represent the functionality of floodplains. In the first school year, the researchers worked on key questions together with the students in workshops, performed field surveys and analyzed the results of fieldwork. In the subsequent discussions, the researchers constantly pointed out the complex interrelations at work in river-floodplain systems. Students’ knowledge was evaluated in pre-project and post-project tests. The analysis of the pre-tests revealed major knowledge gaps on questions concerning river landscape management, e.g. on factors that place major pressures on these regions. A comparison between the pre- and post-tests confirmed a significant improvement in the students’ factual knowledge after the first year; however, the post-project tests only showed a coupling of that knowledge with a recognition of cause-and-effect relations in sporadic cases. Beyond factual knowledge, it is above all a grasp of the interconnections between individual system elements that serves as an essential basis of education. Interactive, modern approaches are critical to conveying interdisciplinary knowledge. As part of the “FlussAu:WOW!” project, in the second school year system-based learning is implemented with the help of innovative modeling and simulation software. In both the pre- and post-tests, questions on the students’ interests revealed a high level of motivation to join in the research, and considerable interest in questions concerning nature and the environment. As a result, by the end of the first school year the cooperation between researchers, educators and students had already made a valuable contribution to sustainable river landscape management.     

The Role of the LINC Complex in Sperm Development and Function

The LINC (LInker of Nucleoskeleton and Cytoskeleton) complex is localized within the nuclear envelope and consists of SUN (Sad1/UNc84 homology domain-containing) proteins located in the inner nuclear membrane and KASH (Klarsicht/Anc1/Syne1 homology domain-containing) proteins located in the outer nuclear membrane, hence linking nuclear with cytoplasmic structures. While the nucleoplasm-facing side acts as a key player for correct pairing of homolog chromosomes and rapid chromosome movements during meiosis, the cytoplasm-facing side plays a pivotal role for sperm head development and proper acrosome formation during spermiogenesis. A further complex present in spermatozoa is involved in head-to-tail coupling. An intact LINC complex is crucial for the production of fertile sperm, as mutations in genes encoding for complex proteins are known to be associated with male subfertility in both mice and men. The present review provides a comprehensive overview on our current knowledge of LINC complex subtypes present in germ cells and its central role for male reproduction. Future studies on distinct LINC complex components are an absolute requirement to improve the diagnosis of idiopathic male factor infertility and the outcome of assisted reproduction.     

Eco-Friendly Natural Clay: Montmorillonite Modified with Nickel or Ruthenium as an Effective Catalyst in Gamma-Valerolactone Synthesis

Catalysis Letters - Ni/Ru metals supported on cheap and available support montmorillonite K10 were used for the selective hydrogenation of levulinic acid to γ-valerolactone. Different loadings...     

Nonparametric Time Series Prediction Through Adaptive Model Selection

We consider the problem of one-step ahead prediction for time series generated by an underlying stationary stochastic process obeying the condition of absolute regularity, describing the mixing nature of process. We make use of recent results from the theory of empirical processes, and adapt the uniform convergence framework of Vapnik and Chervonenkis to the problem of time series prediction, obtaining finite sample bounds. Furthermore, by allowing both the model complexity and memory size to be adaptively determined by the data, we derive nonparametric rates of convergence through an extension of the method of structural risk minimization suggested by Vapnik. All our results are derived for general L error measures, and apply to both exponentially and algebraically mixing processes.     

Modulation of Induced Cytotoxicity of Doxorubicin by Using Apoferritin and Liposomal Cages

Doxorubicin is an effective chemotherapeutic drug, however, its toxicity is a significant limitation in therapy. Encapsulation of doxorubicin inside liposomes or ferritin cages decreases cardiotoxicity while maintaining anticancer potency. We synthesized novel apoferritin- and liposome-encapsulated forms of doxorubicin (“Apodox” and “lip-8-dox”) and compared its toxicity with doxorubicin and Myocet on prostate cell lines. Three different prostatic cell lines PNT1A, 22Rv1, and LNCaP were chosen. The toxicity of the modified doxorubicin forms was compared to conventional doxorubicin using the MTT assay, real-time cell impedance-based cell growth method (RTCA), and flow cytometry. The efficiency of doxorubicin entrapment was 56% in apoferritin cages and 42% in the liposome carrier. The accuracy of the RTCA system was verified by flow-cytometric analysis of cell viability. The doxorubicin half maximal inhibition concentrations (IC₅₀) were determined as 170.5, 234.0, and 169.0 nM for PNT1A, 22Rv1, and LNCaP, respectively by RTCA. Lip8-dox is less toxic on the non-tumor cell line PNT1A compared to doxorubicin, while still maintaining the toxicity to tumorous cell lines similar to doxorubicin or epirubicin (IC₅₀ = 2076.7 nM for PNT1A vs. 935.3 and 729.0 nM for 22Rv1 and LNCaP). Apodox IC₅₀ was determined as follows: 603.1, 1344.2, and 931.2 nM for PNT1A, 22Rv1, and LNCaP.     

Pervaporative Separation of Methanol–Methyl Acetate Mixtures with Commercial PVA Membranes

Pervaporation may successfully be implemented for the separation of azeotropic mixtures which generally requires energy intensive separation procedures. Separation of methanol from methyl acetate by pervaporation is a representative application. In this study the commercial polyvinyl alcohol (PVA)-based membranes PERVAP^TM 4155-30, PERVAP^TM 4155-70, and PERVAP^TM 4155-80 were used to recover methanol from binary methanol–methyl acetate mixtures. The separation performance was investigated for various operating parameters such as feed composition, feed temperature, and permeate pressure and discussed in terms of permeance and selectivity. An empirical model was developed to quantify the effect of membrane swelling on the permeate flux.