A clustering-based modified variable neighborhood search algorithm for a dynamic job shop scheduling problem

The dynamic job shop scheduling (DJSS) problem occurs when some real-time events are taken into account in the ordinary job shop scheduling problem. Most researches about the DJSS problem have focused on methods in which the problem’s input data structure and their probable relationship are not considered in the optimization process while some useful information can be extracted from such data. In this paper, the variable neighborhood search (VNS) combined with the k-means algorithm as a modified VNS (MVNS) algorithm is proposed to address the DJSS problem. The k-means algorithm as a cluster analysis algorithm is used to place similar jobs according to their processing time into the same clusters. Jobs from different clusters are considered to have greater probability to be selected when an adjacent for a solution is made in an optimization process using the MVNS algorithm. To deal with the dynamic nature of the problem, an event-driven policy is also selected. Computational results obtained using the proposed method in comparison with VNS and other common algorithms illustrate better performance in a variety of shop floor conditions.     

Constrained grinding optimization for time,cost, and surface roughness using NSGA-II

Selection of parameters in machining process significantly affects quality, productivity, and cost of a component. This paper presents an optimization procedure to determine the optimal values of wheel speed, workpiece speed, and depth of cut in a grinding process considering certain grinding conditions. Experimental studies have been carried out to obtain optimum conditions. Mathematical models have also been developed for estimating the surface roughness based on experimental investigations. A non-dominated sorting genetic algorithm (NSGA II) is then used to solve this multi-objective optimization problem. The objectives under investigation in this study are surface finish, total grinding time, and production cost subjected to the constraints of production rate and wheel wear parameters. The Pareto-optimal fronts provide a wide range of trade-off operating conditions which an appropriate operating point can be selected by a decision maker. The results show the proposed algorithm demonstrates applicability of machining optimization considering conflicting objectives.     

Investigation on the resistance spot-welded austenitic/ferritic stainless steel

In this work, the effect of weld current on joining capability of austenitic stainless steel (AISI 304) and ferritic stainless steel (AISI 430) sheets with application of resistance spot welding process was investigated. Macrostructure, microstructure, microhardness, tensile shear strength, and failure mode of welded materials were evaluated for different weld currents. The values of weld current were 2.5, 3.75, and 5 kA. It was found that when the weld current increased, the nugget size and the weld strength were increased. Two distinct failure modes including interfacial and pullout were observed during tensile shear test. Finally, an adequate weld current was obtained.     

Optimisation of probiotic yoghurt production enriched with phytosterols

To optimise the formulation of phytosterol‐enriched probiotic yoghurt, the effect of different concentrations of phytosterols, fat and the probiotic inoculation rate on the survival of Lactobacillus acidophilus LA‐5, Bifidobacterium lactis BB‐12 and physicochemical indices over 14 days of storage was explored. Data analysis showed that the phytosterol concentration and fat content were two crucial factors affecting probiotic viability. Addition of phytosterols had no adverse effect on the overall scores for sensory attributes. Regarding maximisation of viability and storage time, the optimum conditions were found to be fat = 8.07% (w/v), phytosterol = 18 g/L, probiotic inoculation rate = 71.42 mg/L and storage time = 12 days.     

Fabrication,characterization and evaluation of the effect of PLGA and PLGA–PEG biomaterials on the proliferation and neurogenesis potential of human neural SH-SY5Y cells

In recent years with regard to the development of nanotechnology and neural stem cell discovery, the combinatorial therapeutic strategies of neural progenitor cells and appropriate biomaterials have raised the hope for brain regeneration following neurological disorders. This study aimed to explore the proliferation and neurogenic effect of PLGA and PLGA–PEG nanofibers on human SH-SY5Y cells in in vitro condition. Nanofibers of PLGA and PLGA–PEG biomaterials were synthesized and fabricated using electrospinning method. Physicochemical features were examined using HNMR, FT-IR, and water contact angle assays. Ultrastructural morphology, the orientation of nanofibers, cell distribution and attachment were visualized by SEM imaging. Cell survival and proliferation rate were measured. Differentiation capacity was monitored by immunofluorescence staining of Map-2. HNMR, FT-IR assays confirmed the integration of PEG to PLGA backbone. Water contact angel assay showed increasing surface hydrophilicity in PLGA–PEG biomaterial compared to the PLGA substrate. SEM analysis revealed the reduction of PLGA–PEG nanofibers' diameter compared to the PLGA group. Cell attachment was observed in both groups while PLGA–PEG had a superior effect in the promotion of survival rate compared to other groups (p < .05). Compared to the PLGA group, PLGA–PEG increased the number of Ki67⁺ cells (p < .01). PLGA–PEG biomaterial induced neural maturation by increasing protein Map-2 compared to the PLGA scaffold in a three-dimensional culture system. According to our data, structural modification of PLGA with PEG could enhance orientated differentiation and the dynamic growth of neural cells.     

Concurrent impact of chipping and pitting damages in a locomotive power transmission system

Journal of Mechanical Science and Technology - The reliability of power transmission systems in locomotives directly impacts trains’ availability and running safety. The failure of gears,...     

Optimization of Output Power and Thermal Efficiency of Solar‐Dish Stirling Engine Using Finite Time Thermodynamic Analysis

This paper presents an investigation on finite time thermodynamic (FTT) evaluation of a solar‐dish Stirling heat engine. FTTs has been applied to determine the output power and the corresponding thermal efficiency, exergetic efficiency, and the rate of entropy generation of a solar Stirling system with a finite rate of heat transfer, regenerative heat loss, conductive thermal bridging loss, and finite regeneration process time. Further imperfect performance of the dish collector and convective/radiative heat transfer mechanisms in the hot end as well as the convective heat transfer in the heat sink of the engine are considered in the developed model. The output power of the engine is maximized while the highest temperature of the engine is considered as a design parameter. In addition, thermal efficiency, exergetic efficiency, and the rate of entropy generation corresponding to the optimum value of the output power is evaluated. Results imply that the optimized absorber temperature is some where between 850 K and 1000 K. Sensitivity of results against variations of the system parameters are studied in detail. The present analysis provides a good theoretical guidance for the designing of dish collectors and operating the Stirling heat engine system.     

Study of Unrecovered Strain and Critical Stresses in One-Way Shape Memory Nitinol

Unique thermomechanical properties of Nitinol known as shape memory and superelasticity make it applicable for different fields such as biomedical, structural, and aerospace engineering. These unique properties are due to the comparatively large recoverable strain, which is being produced in a martensitic phase transformation. However, under certain ranges of stresses and temperatures, Nitinol wires exhibit unrecovered strain. For cyclic applications, it is important to understand the strain behavior of Nitinol wires. In this study, the unrecovered strain of different Nitinol wire diameters was investigated using constant stress experiment. Uniaxial tensile test has been also performed to find the range of critical stresses. It was observed that the unrecovered strain produced in the first loading-unloading cycle affects the total strain in the subsequent cycles. Moreover, a critical range of stress was found beyond which the unrecovered strain was negligible while the wires heated up to the range of 70-80°C, depending on the wire diameters. The unrecovered strain of wire diameters of 0.19 mm and less was found to be sensitive to the critical stress. On the other hand, for wire diameters bigger than 0.19 mm this connection between the unrecovered strain and the critical stress was not observed for the same range of heating temperature.     

Differential Domain Distribution of gnomAD- and Disease-Linked Connexin Missense Variants

Twenty-one human genes encode connexins, a family of homologous proteins making gap junction (GJ) channels, which mediate direct intercellular communication to synchronize tissue/organ activities. Genetic variants in more than half of the connexin genes are associated with dozens of different Mendelian inherited diseases. With rapid advances in DNA sequencing technology, more variants are being identified not only in families and individuals with diseases but also in people in the general population without any apparent linkage to Mendelian inherited diseases. Nevertheless, it remains challenging to classify the pathogenicity of a newly identified connexin variant. Here, we analyzed the disease- and Genome Aggregation Database (gnomAD, as a proxy of the general population)-linked variants in the coding region of the four disease-linked α connexin genes. We found that the most abundant and position-sensitive missense variants showed distinct domain distribution preference between disease- and gnomAD-linked variants. Plotting missense variants on topological and structural models revealed that disease-linked missense variants are highly enriched on the structurally stable/resolved domains, especially the pore-lining domains, while the gnomAD-linked missense variants are highly enriched in the structurally unstable/unresolved domains, especially the carboxyl terminus. In addition, disease-linked variants tend to be on highly conserved residues and those positions show evolutionary co-variation, while the gnomAD-linked missense variants are likely on less conserved residue positions and on positions without co-variation. Collectively, the revealed distribution patterns of disease- and gnomAD-linked missense variants further our understanding of the GJ structure–biological function relationship, which is valuable for classifying the pathogenicity of newly identified connexin variants.