Changes in the respiratory system of patients with rheumatoid arthritis--personal observations

13 patients with RA admitted to our Institute with symptoms of respiratory involvement were described. Taking under consideration pulmonary function tests, radiological findings and histological examinations, we recognised 7 cases with interstitial lung disease, 3 cases with recurrent respiratory infection with bronchiectasis, 1 case with pleuritis, 1 with Caplan's syndrome and 1 with alveolar haemorrhage. The role of RF, and treatment with gold in the development of interstitial lung disease, as well as character of physiologic abnormalities concerning the small airways and its potential connection with bronchiolitis were discussed.     

Determination of porous glass surface free energy components from contact angles

The contact angles of water drops and diiodomethane drops on pellets made of controlled porosity glasses have been measured. The surface of the glasses was modified by thermal treatment at 873 K which led to an increase in the surface concentration of boron atoms. Glass modified with Carbowax 20M (polyethylene glycol) and fully hydroxylated glass have also been studied. Using the measured contact angles and modified Young equation, the dispersion and nondispersion components of the glass surface free energy have been calculated. The values show that with increasing heating time (increasing surface density of boron atoms) an increase in the surface polarity takes place. However, the polarity of the same samples decreases after treatment with Carbowax, increasingly so with higher boron atom concentrations.     

Classification of hyperspectral remote sensing image via rotation-invariant local binary pattern-based weighted generalized closest neighbor

The Journal of Supercomputing - In this article, the authors suggested a rotation-invariant local binary pattern-based weighted generalized closest neighbor (RILBP-WGCN) method for HSI...     

DTA measurements of normal-incommensurate phase transition in (NH4)2ZnCl4 and K2ZnCl4 crystals

Differential thermal analysis (DTA) was applied to determine the changes in enthalpy and entropy of (NH₄)₂ZnCl₄ and K₂ZnCl₄ crystals at their phase transition from the orthorhombic normal phase to the incommensurate phase. The temperature of this transition, T _i , is 406 K for (NH₄)₂ZnCl₄ and 555 K for K₂ZnCl₄ and the entropy changes (S/R) are 0.053 and 0.035, respectively. The low value obtained for S/R is characteristic of incommensurate phase transitions. The results were compared with the data reported for other crystals of the A₂BX₄ family. Thermal properties of the crystals of the A₂ZnCl₄ subgroup were found to the correlated with the length of A-Cl bonds.     

A model with length scales for composites with periodic structure. Steady state heat conduction problem

A new high-order model for analysing distribution of temperature in periodic composites is proposed. The original scalar elliptic problem with Y-periodic coefficients (Y is a cube) is replaced with a vectorial elliptic problem of constant coefficients. The unknown fields are: the averaged distribution of temperature and the vector field which stands for perturbation of the temperature within the cells of periodicity. The recovery of temperature in the original composite is given by the approximation: 0(x)=0(x) +h ^a (x/) _a (x) analogous with the first terms of the two-scale asymptotic expansion known from the homogenization theory. The functions h are defined as approximations of the solutions to the basic cell problems. In contrast to the two-scale expansion the expression for satisfies the boundary condition.     

Polymorphisms in EGFR Gene Predict Clinical Outcome in Unresectable Non-Small Cell Lung Cancer Treated with Radiotherapy and Platinum-Based Chemoradiotherapy

For non-small cell lung cancer (NSCLC), radiotherapy (RT) and platinum-based chemotherapy (CHT) are among the main treatment options. On the other hand, radioresistance and cytotoxic drug resistance are common causes of failure. The epidermal growth factor receptor (EGFR) plays an important role in radioresponse and therapy resistance. We hypothesized that single nucleotide polymorphisms (SNPs) in the EGFR gene might affect individual sensitivity to these treatments, and thus, therapy outcome and prognosis. The association between functional EGFR SNPs and overall (OS), locoregional recurrence-free (LFRS), and metastasis-free (MFS) survival was examined in 436 patients with unresectable NSCLC receiving RT and platinum-based CHTRT. In a multivariate analysis, the rs712830 CC homozygotes showed reduced OS in the whole group (p = 0.039) and in the curative treatment subset (p = 0.047). The rs712829 TT genotype was strongly associated with decreased LRFS (p = 0.006), and the T-C haplotype was a risk factor for locoregional recurrence in our patients (p = 0.003). The rs2227983 GG alone and in combination with rs712829 T was an indicator of unfavorable LRFS (p = 0.028 and 0.002, respectively). Moreover, significant independent effects of these SNPs on OS, LRFS, and MFS were observed. Our results demonstrate that inherited EGFR gene variants may predict clinical outcomes in NSCLC treated with DNA damage-inducing therapy.     

The Co-Culture of Staphylococcal Biofilm and Fibroblast Cell Line: The Correlation of Biological Phenomena with Metabolic NMR1 Footprint

Staphylococcus aureus is one of the most prevalent pathogens associated with several types of biofilm-based infections, including infections of chronic wounds. Mature staphylococcal biofilm is extremely hard to eradicate from a wound and displays a high tendency to induce recurring infections. Therefore, in the present study, we aimed to investigate in vitro the interaction between S. aureus biofilm and fibroblast cells searching for metabolites that could be considered as potential biomarkers of critical colonization and infection. Utilizing advanced microscopy and microbiological methods to examine biofilm formation and the staphylococcal infection process, we were able to distinguish 4 phases of biofilm development. The analysis of staphylococcal biofilm influence on the viability of fibroblasts allowed us to pinpoint the moment of critical colonization—12 h post contamination. Based on the obtained model we performed a metabolomics analysis by ¹H NMR spectroscopy to provide new insights into the pathophysiology of infection. We identified a set of metabolites related to the switch to anaerobic metabolism that was characteristic for staphylococcal biofilm co-cultured with fibroblast cells. The data presented in this study may be thus considered a noteworthy but preliminary step in the direction of developing a new, NMR-based tool for rapid diagnosing of infection in a chronic wound.     

Nomadic Work: Romance and Reality. A Response to Barbara Czarniawska’s ‘Nomadic Work as Life-Story Plot’

This article takes departure in Barbara Czarniawska’s discussion of ‘Nomadic Work as Life-Story Plot’. It contextualises her analysis of actors’ interpretations of nomadic work with a bi-focal review of the ambiguous realities of these phenomena. Firstly, an examination of key aspects of the socio-economic and political context of nomadic work in global neoliberal economies reveals precarious conditions that cloud romantic interpretations of nomadicity. Secondly, a review of studies of everyday practices of nomadic work shows how neoliberal, but also alternative futures are enacted through creative appropriation of collaborative technologies. One example is the work of digital ‘disaster deck’ volunteers and its potential for the mobilization of ‘rapid, highly localized assistance’ through closer collaboration between a distributed crowd, local communities, and official emergency responders (Starbird and Palen 2013). This and other examples suggest emergent new practices and politics of dwelling in mobility that are focused on sociality and collaboration, straddling virtual and physical commons. The twin critique developed in this response can augment narrative analysis to inform more integrated CSCW innovation that challenges the ‘brave new world of work’.