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101.
102.
Lorenzo Landini Daniel Souza Monteiro de Araujo Mustafa Titiz Pierangelo Geppetti Romina Nassini Francesco De Logu 《International journal of molecular sciences》2022,23(9)
The transient receptor potential ankyrin 1 (TRPA1), a member of the TRP superfamily of channels, is primarily localized in a subpopulation of primary sensory neurons of the trigeminal, vagal, and dorsal root ganglia, where its activation mediates neurogenic inflammatory responses. TRPA1 expression in resident tissue cells, inflammatory, and immune cells, through the indirect modulation of a large series of intracellular pathways, orchestrates a range of cellular processes, such as cytokine production, cell differentiation, and cytotoxicity. Therefore, the TRPA1 pathway has been proposed as a protective mechanism to detect and respond to harmful agents in various pathological conditions, including several inflammatory diseases. Specific attention has been paid to TRPA1 contribution to the transition of inflammation and immune responses from an early defensive response to a chronic pathological condition. In this view, TRPA1 antagonists may be regarded as beneficial tools for the treatment of inflammatory conditions. 相似文献
103.
Cagatay Yelkarasi Nina Recek Kursat Kazmanli Janez Kova
Miran Mozeti
Mustafa Urgen Ita Junkar 《International journal of molecular sciences》2022,23(9)
Nanoporous ceramic coatings such as titania are promoted to produce drug-free cardiovascular stents with a low risk of in-stent restenosis (ISR) because of their selectivity towards vascular cell proliferation. The brittle coatings applied on stents are prone to cracking because they are subjected to plastic deformation during implantation. This study aims to overcome this problem by using a unique process without refraining from biocompatibility. Accordingly, a titanium film with 1 µm thickness was deposited on 316 LVM stainless-steel sheets using magnetron sputtering. Then, the samples were anodized to produce nanoporous oxide. The nanoporous oxide was removed by ultrasonication, leaving an approximately 500 nm metallic titanium layer with a nanopatterned surface. XPS studies revealed the presence of a 5 nm-thick TiO2 surface layer with a trace amount of fluorinated titanium on nanopatterned surfaces. Oxygen plasma treatment of the nanopatterned surface produced an additional 5 nm-thick fluoride-free oxide layer. The samples did not exhibit any cracking or spallation during plastic deformation. Cell viability studies showed that nanopatterned surfaces stimulate endothelial cell proliferation while reducing the proliferation of smooth muscle cells. Plasma treatment further accelerated the proliferation of endothelial cells. Activation of blood platelets did not occur on oxygen plasma-treated, fluoride-free nanopatterned surfaces. The presented surface treatment method can also be applied to other stent materials such as CoCr, nitinol, and orthopedic implants. 相似文献
104.
东营凹陷和惠民凹陷作为济阳坳陷南部两个相邻的、构造格局相似的陆相箕状断陷,其石油地质特征有相似之处,但油气富集程度有明显差异。控制油气富集的主要因素有油源条件、构造特征、火山活动以及生储盖组合与构造的配置等。生储盖组合与构造特征的配置,是造成不同构造部位主要储油气层位和油气藏类型差异性的直接原因。结合油源特征、生储盖组合和输导系统特征,东营、惠民凹陷的油气成藏模式可归为5种类型:洼陷带自生自储-侧向运移成藏模式、洼陷区上生下储-垂向运移成藏模式、中央隆起带和北部陡坡带下生上储-垂向运移成藏模式、南部斜坡带下生上储-复合运移成藏模式和周边凸起区新生古储-复合成藏模式。 相似文献
105.
Yongchao Tang Yue Wei Anthony F.Hollenkamp Mustafa Musameh Aaron Seeber Tao Jin Xin Pan Han Zhang Yanan Hou Zongbin Zhao Xiaojuan Hao Jieshan Qiu Chunyi Zhi 《纳微快报(英文)》2021,(11):280-293
As promising anodes for sodium-ion batteries, metal sulfides ubiquitously suffer from low-rate and high-plateau issues, greatly hindering their application in f... 相似文献
106.
Evaluation of damage to light structures erected on a fill material rich in expansive soil 总被引:2,自引:0,他引:2
Mustafa Ozer Resat Ulusay Nihat Sinan Isik 《Bulletin of Engineering Geology and the Environment》2012,71(1):21-36
The paper reports a study of the cause of defects in light structures and the toppling of a wall constructed on a fill material
rich in Ankara clay. Laboratory tests were carried out on vertical and horizontal samples from boreholes and a trial pit was
excavated near the damaged structures. The results showed that in the vicinity of the toppled wall, swelling pressures in
the horizontal direction were greater than those measured in the vertical direction. The swelling properties of the fill material
were higher than those of original Ankara clay as determined previously by other investigators, suggesting that breakdown
of the cementing bonds and a change in the fabric are the main factors affecting the swelling pressure of disturbed and compacted
expansive soils. The calculations to predict uplift showed a good agreement with the observations in the damaged structures.
It is concluded that swelling was the main cause of the damage to the light structures at the study site and resulted from
the highly expansive nature of the fill material, poor drainage, the semi-arid climate, poor construction methods and ineffective
precautions. Some recommendations for minimizing the effects of swelling at the study site are briefly outlined. 相似文献
107.
N. Emrahoğlu İ. Yeğingil V. Peştemalci O. Şenkal H. M. Kandirmaz 《International journal of remote sensing》2013,34(4):649-655
In this study, a new classification algorithm in which only the selected pixels have been attempted to be classified (selected pixels classification: SPC) has been introduced and compared with the well known supervised classification methods such as maximum likelihood, minimum distance, nearest neighbour and condensed nearest neighbour. To examine the algorithm, Landsat Thematic Mapper (TM) data have been used to classify the crop cover in the selected region. It is clearly demonstrated that the SPC method has the higher accuracy with comparable CPU times. 相似文献
108.
This paper introduces a new model for robot behavior categorization. Correlation based adaptive resonance theory (CobART) networks are integrated hierarchically in order to develop an adequate categorization, and to elicit various behaviors performed by the robot. The proposed model is developed by adding a second layer CobART network which receives first layer CobART network categories as an input, and back-propagates the matching information to the first layer networks. The first layer CobART networks categorize self-behavior data of a robot or an object in the environment while the second layer CobART network categorizes the robot's behavior with respect to its effect on the object. Experiments show that the proposed model generates reasonable categorization of behaviors being tested. Moreover, it can learn different forms of the behaviors, and it can detect the relations between them. In essence, the model has an expandable architecture and it contains reusable parts. The first layer CobART networks can be integrated with other CobART networks for another categorization task. Hence, the model presents a way to reveal all behaviors performed by the robot at the same time. 相似文献
109.
110.
Turkey has a great number of hazelnut trees that possess nutritious components. However, only the inside part of the hazelnut is used as a nutrient, while the rest of it is waste. This study suggests that the waste parts of the Turkish hazelnut could be used as a natural dye for dyeing textile fabrics. The dyeing properties of the leaves, coat, shell and dice of the hazelnut were studied on wool, cotton and viscose fabric by using three different mordants: copper sulphate, iron sulphate and aluminium sulphate. The selected dyed fibre sample surfaces were observed using a scanning electron microscope. The colour strength (K/S), light, washing, rubbing, and perspiration fastness levels of the dyed fabrics were investigated. The experimental natural dyeing results indicate that waste hazelnut‐based products can be used as a natural dye for textile coloration. 相似文献