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101.
Y Miwa M Negishi R Hanaoka Y Hatano H Iwabuchi H Kanemitu S Kaga M Hashimoto T Kasama H Ide E Shimada K Tadokoro 《Canadian Metallurgical Quarterly》1998,38(5):735-740
Recurrent respiratory papillomatosis (RRP), usually confined to the nasopharynx, trachea, and larynx, occasionally can progress to extensive bronchopulmonary disease. Most cases of bronchopulmonary and laryngeal papillomatosis are cytologically benign and do not undergo malignant transformation; however, squamous cell carcinoma (SCC) can arise in RRP in the absence of known risk factors such as radiation and smoking. In this study, the authors investigated molecular genetic alterations occurring in a case of metastasizing SCC that arose in long-standing bronchopulmonary papillomatosis. Genomic DNA from tracheal papillomata, tracheobronchial papillomata, SCC of the lung, and a lymph node metastasis was extracted. The physical state of the human papillomavirus type 11 (HPV-11) DNA was investigated by two-dimensional gel electrophoresis. Molecular genetic alterations of the host genome were studied by direct sequencing of polymerase chain reaction-amplified gene fragments and restriction fragment length polymorphism (RFLP) analysis. Episomal and integrated forms of HPV-11 sequences were detected in histologically benign tumors, but only the integrated form of the viral DNA could be found in malignant tissue samples. Molecular genetic studies revealed that an allelic loss of the interferon-beta gene (IFNbeta-1) and an endogenous type of mutation of the p53 antioncogene were found only in the malignant lesions. Mutations were not observed in the ras, neu, or multiple tumor suppressor (MTS1/p16) genes in any specimens. The authors' data indicated that the p53 genetic mutation was associated with integration of HPV-11 in histologically malignant lesions. This association may promote a progressive genetic instability that can lead to the development and clonal expansion of malignant lesions in RRP. 相似文献
102.
T Miyamoto Y Kuramitsu A Ookuma S Trevanich K Honjoh S Hatano 《Canadian Metallurgical Quarterly》1998,61(10):1312-1316
A physical, cognitive, or mental disability presents significant challenges to an individual in gaining access to a coordinated program of preventive, primary, and secondary health care services. This article describes the health care needs of people with disabilities and discusses how the financial incentives in managed care may threaten access to the health care services they need to maintain their health and functional independence. We argue that despite the shortcomings of present models, managed care has the potential to improve the health care of people with disabilities. Moreover, as health plans become increasingly accountable to consumers (and begin to compete on the basis of quality), they will not be able to ignore the distinct health care needs of people with disabilities. 相似文献
103.
A new hydrogen production method, the HyPr-RING process was applied to a vacuum residue of Arabian light crude oil to clarify the effects of added water, calcium hydroxide, which absorbs carbon dioxide, and the reaction temperature. It was determined that when a sufficient amount of calcium hydroxide was present, it provided enough water to produce hydrogen and additional water was not necessary. To consume all of the carbon dioxide in 1 mol of carbon from the feedstock, 25 mol% of calcium hydroxide was needed and hydrogen production was saturated at 50 mol%. Carbon conversion was dependent mainly on the temperature and was slightly dependent on water and pressure. The reaction pressure was as low as 4.2 MPa. Thermal decomposition of the feedstock was the dominant reaction below 600 °C, which produced methane. 相似文献
104.
105.
Sui Jung?Kang Shigeki?Yokoyama Nobuou?Matsuzaka Nanae?Hatano Takahiro?Kobayashi Rie?Touma Takakazu?IshimatsuEmail author 《Artificial Life and Robotics》2004,8(1):38-41
A technique to analyze the functional instability of an ankle is proposed. The technique is based on measurements using two digital still cameras. We carried out several experiments using this technique. Subjects are requested to stand on an experimental table whose angle of inclination is adjusted. By comparing the postures of both feet, we could tell that the subjects had experienced an ankle sprain and had functional instabilities in their ankles.This work was presented in part at the 8th International Symposium on Artificial Life and Robotics, Oita, Japan, January 24–26, 2003 相似文献
106.
A new interferometer for extreme ultraviolet (EUV) radiation with a laser produced plasma (LPP) laboratory source is under construction. The LPP source is operated with a Sn solid rod target on which pulsed YAG laser is focused to produce high temperature plasma emitting EUV radiation. The source is equipped with a newly designed debris stopper protecting a condenser multilayer mirror from the particle debris of the target. The condenser mirror focuses the light onto an EUV beam - splitter to form transmitted and reflected paths for producing interference fringes of a sharing type. The optical configuration is of a common path based on a triangular path type with a focusing at the beam- splitter, which is enabled to produce fringes by a low coherence radiation with a standard optical quality beam - splitter. The fringes are recorded by an imaging plate with pixels as small as 25μm. The dynamic range of linearity in detection of the EUV light was found to be more than 10^4 with sensitivity of 10^4 photo ns/pixel, enough for the purpose of interferogram recording possibly with one laser shot. 相似文献
107.
Planar thin-films of a 60ZrF4 · 35BaF2 · 5PrF3 composition were successfully prepared from Zr(hfa)4, Ba(hfa)2(tg), Pr(fod)3 and NF3 by an electron cyclotron resonance plasma-enhanced chemical vapor deposition technique. The films obtained were colorless and amorphous. As etching processing of the prepared thin-film, dry etching was performed using Ar, CF4, SF6, Cl2 and Cl2-BCl3 gases. The Ar etching in which no reactive ion-etching is anticipated exhibited the fastest etching rate. Wet etching was also performed using a ZrOCl2-HCl etching solution. The etching rate was extremely fast compared with those of dry etching. In this etching, however, undesirable side-etching occurred. At the present stage, therefore, the most preferable etching processing is dry etching by an Ar gas. 相似文献
108.
Takaya M. Katagiri T. Nagasawa S. Murakami Y. Hatano S. 《Advanced Packaging, IEEE Transactions on》2000,23(1):36-41
Two new optical fiber joining techniques have been developed for aerial distribution cables. One employs a compact mass-fusion splicer and the other involves a small mechanical splice. This paper describes their design and performance. These techniques are excellent for use in aerial sites and enable aerial distribution cable systems to be constructed efficiently. They will be useful for the economical construction of optical access networks for fiber-to-the-home 相似文献
109.
Keiko Sato Masami Naya Yuri Hatano Yoshio Kondo Mari Sato Keiji Nagano Shicheng Chen Mariko Naito Chikara Sato 《International journal of molecular sciences》2021,22(4)
The Gram-negative bacterium Flavobacterium johnsoniae employs gliding motility to move rapidly over solid surfaces. Gliding involves the movement of the adhesin SprB along the cell surface. F. johnsoniae spreads on nutrient-poor 1% agar-PY2, forming a thin film-like colony. We used electron microscopy and time-lapse fluorescence microscopy to investigate the structure of colonies formed by wild-type (WT) F. johnsoniae and by the sprB mutant (ΔsprB). In both cases, the bacteria were buried in the extracellular polymeric matrix (EPM) covering the top of the colony. In the spreading WT colonies, the EPM included a thick fiber framework and vesicles, revealing the formation of a biofilm, which is probably required for the spreading movement. Specific paths that were followed by bacterial clusters were observed at the leading edge of colonies, and abundant vesicle secretion and subsequent matrix formation were suggested. EPM-free channels were formed in upward biofilm protrusions, probably for cell migration. In the nonspreading ΔsprB colonies, cells were tightly packed in layers and the intercellular space was occupied by less matrix, indicating immature biofilm. This result suggests that SprB is not necessary for biofilm formation. We conclude that F. johnsoniae cells use gliding motility to spread and maturate biofilms. 相似文献
110.
Naomi Hirayama Akira Endo Kazuhiro Fujita Yasuhiro Hasegawa Naomichi Hatano Hiroaki Nakamura Ryōen Shirasaki 《Computer Physics Communications》2011,(1):90-92
The thermoelectric and thermomagnetic phenomena of two-dimensional electron gases at low temperatures are numerically examined using the finite-difference method. The temperature and the voltage are calculated from transport equations describing thermoelectric and thermomagnetic effects. The results demonstrate that a magnetic field distorts equipotential lines and generates an uneven distribution of the temperature, which can cause inhomogeneous heating of experimental systems. In particular, a part of the system is found to be colder than the temperature of the heat baths. 相似文献