Alpha-tricalcium phosphate (α-TCP): solid state synthesis from different calcium precursors and the hydraulic reactivity

The effects of solid state synthesis process parameters and primary calcium precursor on the cement-type hydration efficiency (at 37°C) of α-tricalcium phosphate (Ca₃(PO₄)₂ or α-TCP) into hydroxyapatite (Ca_10−xHPO₄(PO₄)_6−x(OH)_2−x x = 0–1, or HAp) have been investigated. α-TCP was synthesized by firing of stoichiometric amount of calcium carbonate (CaCO₃) and monetite (CaHPO₄) at 1150–1350°C for 2 h. Three commercial grade CaCO₃ powders of different purity were used as the starting material and the resultant α-TCP products for all synthesis routes were compared in terms of the material properties and the reactivity. The reactant CaHPO₄ was also custom synthesized from the respective CaCO₃ source. A low firing temperature in the range of 1150–1350°C promoted formation of β-polymorph as a second phase in the resultant TCP. Meanwhile, higher firing temperatures resulted in phase pure α-TCP with poor hydraulic reactivity. The extension of firing operation also led to a decrease in the reactivity. It was found that identical synthesis history, morphology, particle size and crystallinity match between the α-TCPs produced from different CaCO₃ sources do not essentially culminate in products exhibiting similar hydraulic reactivity. The changes in reactivity are arising from differences in the trace amount of impurities found in the CaCO₃ precursors. In this regard, a correlation between the observed hydraulic reactivities and the impurity content of the CaCO₃ powders—as determined by inductively coupled plasma mass spectrometry—has been established. A high level of magnesium impurity in the CaCO₃ almost completely hampers the hydration of α-TCP. This impurity also favors formation of β- instead of α-polymorph in the product of TCP upon firing.     

Effect of pulse potential on alkaline water electrolysis performance

In this study, the effect of pulse potential on alkaline water electrolysis energy consumption is investigated. A specially designed electrical circuit is used to observe the effect of different duty cycles and frequency values on water electrolysis energy consumption in different concentration values of alkaline solution. The results show that using pulse potential enhances the mass transport of oxygen and hydrogen bubbles due to the pumping effect. This provides less contact with oxygen bubbles to improve corrosion resistance of anode electrodes. Moreover, decreasing mass transfer losses on the electrode surface resulted in a 20–25% lower energy consumption to produce 1 mol of hydrogen in the cell. The optimum frequency for 10% and 50% duty cycle and 10% and 15% concentration are investigated. For 10% duty cycle, the optimum frequency is specified around 140–200 kHz and for 50% duty cycle, it is around 380–400 kHz for all concentration values.     

A new approach for fuel injection into a solar receiver/ reactor: Numerical and experimental investigation

An innovative and efficient design of solar receivers/reactors can enhance the production of clean fuels via concentrated solar energy. This study presents a new jet-type burner nozzle for gaseous feedstock injection into a cavity solar receiver inspired from the combustion technology. The nozzle design was adapted from a combustion burner and successfully implemented into a solar receiver and studied the influence of the nozzle design on the fluid mixing and temperature distribution inside the solar receiver using a 7 kW solar simulator and nitrogen as working fluid. Finally, a thorough computational fluid dynamics (CFD) analysis was performed and validated against the experimental results. The CFD results showed a variation of the gas flow pattern and gas mixing after the burner nozzle adaptation, which resulted an intense effect on the heat transfer inside the solar receiver.

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Characteristics of meat emulsion systems as influenced by different levels of lemon albedo

The effect of the addition of lemon albedo on the functional properties of emulsions was studied by using a model system. Oil/water (O/W) model emulsion systems were prepared by the addition of two types of lemon albedo (raw and dehydrated) at five concentrations (0.0%, 2.5%, 5.0%, 7.5% and 10%) to mechanically deboned chicken meat. The emulsion capacity, stability, viscosity and flow properties of the prepared model emulsions were analyzed. In addition, the colour parameters of cooked emulsion gel were determined. The addition of lemon albedo increased the emulsion capacity (EC) and the highest EC value was reached with 5% of albedo added. However, further increase in the albedo concentration caused an inverse trend in the EC values. A similar trend was observed in the emulsion stability (ES) values. Dehydrated albedo (DA) addition caused higher EC and ES values than did raw albedo (RA). DA increased the L^∗, a^∗ and b^∗ values of the cooked emulsion gels. Emulsion viscosity (EV) values were positively correlated with an increase in albedo concentration and the highest EV value was obtained from the emulsions with 10% albedo. Albedo addition did not change the flow properties of the emulsions and, in addition, increased the pseudoplasticity. As a consequence, the use of lemon albedo might be a potential dietary fiber source to enhance the functional and technological properties for frankfurter-type meat products.     

Effect of scaffold architecture and BMP-2/BMP-7 delivery on in vitro bone regeneration

The aim of this study was to develop 3-D tissue engineered constructs that mimic the in vivo conditions through a self-contained growth factor delivery system. A set of nanoparticles providing the release of BMP-2 initially followed by the release of BMP-7 were incorporated in poly(ε-caprolactone) scaffolds with different 3-D architectures produced by 3-D plotting and wet spinning. The release patterns were: each growth factor alone, simultaneous, and sequential. The orientation of the fibers did not have a significant effect on the kinetics of release of the model protein BSA; but affected proliferation of bone marrow mesenchymal stem cells. Cell proliferation on random scaffolds was significantly higher compared to the oriented ones. Delivery of BMP-2 alone suppressed MSC proliferation and increased the ALP activity to a higher level than that with BMP-7 delivery. Proliferation rate was suppressed the most by the sequential delivery of the two growth factors from the random scaffold on which the ALP activity was the highest. Results indicated the distinct effect of scaffold architecture and the mode of growth factor delivery on the proliferation and osteogenic differentiation of MSCs, enabling us to design multifunctional scaffolds capable of controlling bone healing.     

Oxygen plasma modification of polyurethane membranes

Polyurethane membranes were prepared under nitrogen atmosphere by using various proportions of toluene diisocyanates (TDI) and polypropylene-ethylene glycol (P) with addition of no other ingredients such as catalysts, initiator or solvent in order to achieve medical purity. Effects of composition on mechanical properties were examined. In general, modulus and UTS values demonstrated an increase and PSBR demonstrated a decrease as the TDI/Polyol ratio of the polymer increased. Elastic modulus, ultimate tensile strength (UTS) and per cent strain before rupture (PSBR) values were found to be in the range of 1.4–5.4 MPa, 0.9–1.9 MPa, and 60.4–99.7%, respectively. Surfaces of the membranes were modified by oxygen plasma applying glow-discharge technique and the effect of applied plasma power (10 W or 100 W, 15 min) on surface hydrophilicity and on the attachment of Vero cells were studied. Water contact angle values of the plasma modified surfaces varied between 67° and 46°, demonstrating a decrease as the applied plasma power was increased. The unmodified material had 42–45 cells attached per cm². It was observed that as the applied power increased the number of attached cells first increased (60–70 cells/cm² at 10 W) and then decreased (27–40 cells/cm² at 100 W). These demonstrated that surface properties of polyurethanes can be modified by plasma-glow discharge technique to achieve the optimum levels of cell attachment.     

Experimental investigation on performance and emission characteristics of waste tire pyrolysis oil–diesel blends in a diesel engine

Disposal of waste tires is one of the most important problems that should be solved. This problem can be solved by considering waste tires for production of hydrogen or fuel for diesel engines. This paper presents the studies on the performance and emission characteristics of a four stroke, four cylinders, naturally aspirated, direct-injected diesel engine running with various blends of waste tire pyrolysis oil (WTPO) with diesel fuel. Fuel properties, engine performance, and exhaust emissions of WTPO and its blends were analyzed and compared with those of petroleum diesel fuel. The experimental results showed that WTPO–diesel blends indicated similar performance with diesel fuel in terms of torque and power output of the test engine. It was found that the blends of pyrolysis oil of waste tire WTPO10 can efficiently be used in diesel engines without any engine modifications.     

Smartphone addiction and its relationship with social anxiety and loneliness

Individuals with psychosocial problems such as social phobia or feelings of loneliness might be vulnerable to excessive use of cyber-technological devices, such as smartphones. We aimed to determine the relationship of smartphone addiction with social phobia and loneliness in a sample of university students in Istanbul, Turkey. Three hundred and sixty-seven students who owned smartphones were given the Smartphone Addiction Scale (SAS), UCLA Loneliness Scale (UCLA-LS), and Brief Social Phobia Scale (BSPS). A significant difference was found in the mean SAS scores (p?<?.001) between users who declared that their main purpose for smartphone use was to access social networking sites. The BSPS scores showed positive correlations with all six subscales and with the total SAS scores. The total UCLA-LS scores were positively correlated with daily life disturbance, positive anticipation, cyber-oriented relationship, and total scores on the SAS. In regression analyses, total BSPS scores were significant predictors for SAS total scores (β?=?0.313, t?=?5.992, p?<?.001). In addition, BSPS scores were significant predictors for all six SAS subscales, whereas UCLA-LS scores were significant predictors for only cyber-oriented relationship subscale scores on the SAS (β?=?0.130, t?=?2.416, p?<?.05). The results of this study indicate that social phobia was associated with the risk for smartphone addiction in young people. Younger individuals who primarily use their smartphones to access social networking sites also have an excessive pattern of smartphone use.     

Validation of l-Tellurienylalanine as a Phenylalanine Isostere

Mass cytometry (MC) and imaging mass cytometry (IMC^TM) have emerged as important tools for the study of biological heterogeneity. We recently demonstrated the use of l -2-tellurienylalanine (TePhe), a mimic of phenylalanine (Phe), as an MC- and IMC-compatible protein synthesis reporter. In this work, the biochemical similarity of TePhe and its cognate analogue, Phe, are examined in the context of the RNase S complex. Isothermal titration calorimetry studies show that incorporation of TePhe preserves the interaction of S-peptide with S-protein, and the dissociation constants for the interaction of the Phe and TePhe peptides are within a factor of two. The resulting RNase S complex is catalytically active without significant alterations in the enzyme's kinetic parameters. Furthermore, circular dichroism spectroscopy does not reveal any changes to the secondary structure of TePhe-substituted RNase S. These findings provide strong evidence that TePhe functions as a Phe isostere in the context of a folded protein. It is anticipated that incorporation of TePhe into peptides or peptidomimetic scaffolds will enable facile generation of MC and IMC^TM probes.