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41.
The main purpose of a gene interaction network is to map the relationships of the genes that are out of sight when a genomic study is tackled. DNA microarrays allow the measure of gene expression of thousands of genes at the same time. These data constitute the numeric seed for the induction of the gene networks. In this paper, we propose a new approach to build gene networks by means of Bayesian classifiers, variable selection and bootstrap resampling. The interactions induced by the Bayesian classifiers are based both on the expression levels and on the phenotype information of the supervised variable. Feature selection and bootstrap resampling add reliability and robustness to the overall process removing the false positive findings. The consensus among all the induced models produces a hierarchy of dependences and, thus, of variables. Biologists can define the depth level of the model hierarchy so the set of interactions and genes involved can vary from a sparse to a dense set. Experimental results show how these networks perform well on classification tasks. The biological validation matches previous biological findings and opens new hypothesis for future studies. 相似文献
42.
Jan Rosell Carlos Vázquez Alexander Pérez Pedro Iñiguez 《Journal of Intelligent and Robotic Systems》2008,53(3):223-245
Haptic devices allow a user to feel either reaction forces from virtual interactions or reaction forces reflected from a remote
site during a bilateral teleoperation task. Also, guiding forces can be exerted to train the user in the performance of a
virtual task or to assist him/her to safely teleoperate a robot. The generation of guiding forces relies on the existence
of a motion plan that provides the direction to be followed to reach the goal from any free configuration of the configuration
space (-space). This paper proposes a method to obtain such a plan that interleaves a sampling-based exploration of -space with an efficient computation of harmonic functions. A deterministic sampling sequence (with a bias based on harmonic
function values) is used to obtain a hierarchical cell decomposition model of -space. A harmonic function is iteratively computed over the partially known model using a novel approach. The harmonic function
is the navigation function used as motion plan. The approach has been implemented in a planner (called the Kautham planner) that, given an initial and a goal configuration, provides: (a) a channel of cells connecting the cell that contains
the initial configuration with the cell that contains the goal configuration; (b) two harmonic functions over the whole -space, one that guides motions towards the channel and another that guides motions within the channel towards the goal; and
(c) a path computed over a roadmap built with the free samples of the channel. The harmonic functions and the solution path
are then used to generate the guiding forces for the haptic device. The planning approach is illustrated with examples on
2D and 3D workspaces.
This work was partially supported by the CICYT projects DPI2005-00112 and DPI2007-63665. 相似文献
43.
Leonid B. Freidovich Pedro La Hera Uwe Mettin Anders Robertsson Anton S. Shiriaev Rolf Johansson 《Asian journal of control》2009,11(5):548-556
We consider an underactuated two‐link robot called the inertia wheel pendulum. The system consists of a free planar rotational pendulum and a symmetric disk attached to its end, which is directly controlled by a DC‐motor. The goal is to create stable oscillations of the pendulum, which is not directly actuated. We exploit a recently proposed feedback‐control design strategy based on motion planning via virtual holonomic constraints. This strategy is shown to be useful for design of regulators for achieving orbitally exponentially stable oscillatory motions. The main contribution is a step‐by‐step procedure on how to achieve oscillations with pre‐specified amplitude from a given range and an arbitrary independently chosen period. The theoretical results are verified via experiments with a real hardware setup. Copyright © 2009 John Wiley and Sons Asia Pte Ltd and Chinese Automatic Control Society 相似文献
44.
Pedro Furtado 《Service Oriented Computing and Applications》2009,3(3):159-169
Typical request processing systems, such as web servers and database servers, try to accommodate all requests as fast as possible,
which can be described as a Best-Effort approach. However, different application items may have different quality-of-service
(QoS) requirements, and this can be viewed as an orthogonal concern to the basic system functionality. In this paper we propose
the QoS-Broker, a middleware for delivering QoS over servers and applications. We show its architecture to support contracts
over varied targets including queries, transactions, services or sessions, also allowing expressions on variables to be specified
in those targets. We also discuss how the QoS-Broker implements basic strategies for QoS over workloads. Our experimental
results illustrate the middleware by applying priority and weighted- fair-queuing based differentiation over clients and over
transactions, and also admission control, using a benchmark as a case-study. 相似文献
45.
Elena Molina Mercedes Ramos Pedro J. Martin-álvarez 《Zeitschrift für Lebensmitteluntersuchung und -Forschung A》1995,201(4):331-335
Stepwise multiple linear regression (SMLR) and principal components regression (PCR) have been used to predict the percentages of cows', goats' and ewes' milk in Iberico cheese, using the results obtained by electrophoretic analysis (PAGE and IEF) of whey proteins, using standard cheeses. Similar predictions of the percentages of milks from the three species were obtained when either SMLR or PCR were applied to the electrophoretic data, i.e. the optical intensity of the electrophoretic bands (PAGE or IEF) of the whey proteins. The root mean square error of prediction in cross-validation (RMSEPCV) was lower than 4% in all cases. 相似文献
46.
Fouto Ana R. Nunes Rita G. Pinto Joana Alves Luísa Calado Sofia Gonçalves Carina Rebolo Margarida Viana-Baptista Miguel Vilela Pedro Figueiredo Patrícia 《Magma (New York, N.Y.)》2022,35(5):779-790
Magnetic Resonance Materials in Physics, Biology and Medicine - Histogram-based metrics extracted from diffusion-tensor imaging (DTI) have been suggested as potential biomarkers for cerebral small... 相似文献
47.
Ortega-Cabezas Pedro Miguel Colmenar-Santos Antonio Borge-Diez David Blanes-Peiró Jorge Juan Higuera-Pérez Jorge Alcaide Eric 《Software Quality Journal》2022,30(3):687-728
Software Quality Journal - The number of electronic control units (ECU) installed in vehicles is increasingly high. Manufacturers must improve the software quality and reduce cost by proposing... 相似文献
48.
Mu Lei Wang Yuan Zang Yong Araujo Stemler Pedro Malaquias 《Journal of Failure Analysis and Prevention》2017,17(2):321-329
This paper is a contribution to the prediction of edge fracture behavior using uncoupled ductile fracture models. A fully integrated simulation framework for the edge fracture prediction is proposed with the shear-induced pre-damage considered. User-defined material subroutines are coded with uncoupled ductile fracture models (Lou-Huh, Oh, Brozzo) incorporated, which are calibrated using the fracture strains of various loading paths. A series of 3D numerical simulations are performed and compared with the results of hole-expansion tests. The effects of pre-damage field and fracture models are analyzed and discussed.
相似文献49.
In the steel industry, the iron making system deals with large quantities of materials and energy and so it can play a critical role in reducing emissions and production costs. More specifically, excess by-product gases should be used for electricity generation; otherwise, they lead to pollution. A life cycle analysis is performed to compare the environmental impact of an iron making system with a combined cycle power plant (CCPP), to a system producing the same amount of electricity in a coal power plant. The results for a Chinese steel plant show a 33% reduction in the energy conservation and emission reduction potential for the CCPP system, which is thus more environmentally friendly. A mathematical programming formulation is then proposed for optimal scheduling. It incorporates key technological constraints and is sensitive to hourly changing electricity prices. The outcome is a 19% increase in revenue from electricity sales compared to a schedule that does not dynamically adjust to the price profile. The results also show that emissions from by-product gases can be avoided completely. The paper ends with a sensitivity analysis to evaluate the impact of changes in product demand, gas storage and CCPP capacity, and emission cost. 相似文献
50.
Criticality Analysis for Maintenance Purposes: A Study for Complex In‐service Engineering Assets
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Adolfo Crespo Márquez Pedro Moreu de León Antonio Sola Rosique Juan F. Gómez Fernández 《Quality and Reliability Engineering International》2016,32(2):519-533
The purpose of this paper is to establish a basis for a criticality analysis, considered here as a prerequisite, a first required step to review the current maintenance programs, of complex in‐service engineering assets. Review is understood as a reality check, a testing of whether the current maintenance activities are well aligned to actual business objectives and needs. This paper describes an efficient and rational working process and a model resulting in a hierarchy of assets, based on risk analysis and cost–benefit principles, which will be ranked according to their importance for the business to meet specific goals. Starting from a multicriteria analysis, the proposed model converts relevant criteria impacting equipment criticality into a single score presenting the criticality level. Although detailed implementation of techniques like Root Cause Failure Analysis and Reliability Centered Maintenance will be recommended for further optimization of the maintenance activities, the reasons why criticality analysis deserves the attention of engineers and maintenance and reliability managers are precisely explained here. A case study is presented to help the reader understand the process and to operationalize the model. Copyright © 2015 John Wiley & Sons, Ltd. 相似文献