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RD Smith L Hunyady JA Olivares-Reyes B Mihalik S Jayadev KJ Catt 《Canadian Metallurgical Quarterly》1998,54(6):935-941
Autosomal recessive juvenile parkinsonism (AR-JP) is a distinct clinical and genetic entity characterized by selective degeneration of nigral dopaminergic neurons and young-onset parkinsonism with remarkable response to levodopa. Recently, we mapped the gene locus for AR-JP to chromosome 6q25.2-q27 by linkage analysis and we identified a novel large gene, Parkin, consisting of 12 exons from this region; mutations of this gene were found to be the cause of AR-JP in two families. Now we report results of extensive molecular analysis on 34 affected individuals from 18 unrelated families with AR-JP. We found four different homozygous intragenic deletional mutations, involving exons 3 to 4, exon 3, exon 4, and exon 5 in 10 families (17 affected individuals). In addition to the exonic deletions, we identified a novel one-base deletion involving exon 5 in two families (2 affected individuals). All mutations so far found were deletional types in which large exonic deletion accounted for 50% (17 of 34) and the one-base deletion accounted for 6% (2/34); in the remaining, no homozygous mutations were found in the coding regions. Our findings indicate that loss of function of the Parkin protein results in the clinical phenotype of AR-JP and that subregions between introns 2 and 5 of the Parkin gene are mutational hot spots. 相似文献
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A random telephone survey was used to interview 598 employees about instances, if any, when they had been physically attacked or threatened in the workplace. Demographic and workplace characteristics are analyzed as correlates of these forms of violence. The only characteristic consistently associated with higher risk is a work schedule that included nighttime hours. However, although few strong or consistent correlates of workplace violence were found, there were clear negative consequences associated with being victimized at work: lower job satisfaction, greater job stress, increased considerations of job change, and an increased likelihood of bringing mace, a gun, or another weapon to work. 相似文献
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RD Howard RS Martens SA Innis JM Drnevich J Hale 《Canadian Metallurgical Quarterly》1998,55(5):1151-1163
A sexual size dimorphism usually occurs when size-dependent reproductive advantages exist in only one sex. Studies on Japanese medaka, Oryzias latipes, have demonstrated reproductive size advantages in females but not in males, even though males and females are similar in body size. We conducted mate-choice and mate-copying tests in which a female could first associate with, then mate with, either a large (>/=1 sd+X standard length) or a small male (=1 sd-X standard length). Large males obtained a mating advantage in both tests, and both mate choice and mate competition influenced their mating success. In the majority of trials, females associated with large males. Association preferences of females corresponded to their mating preferences when mate competition between males was weak; however, when mate competition was strong, large males obtained almost every mating regardless of female association preference. Preference for large males may provide females with a reproductive advantage if males mate multiply because small males become sperm-depleted sooner than large males. We found no indication that females copied the mating decisions of other females. Repeatability of female mating preference was low, not because females mated at random with respect to male size, but because most females consistently preferred large males. We also conducted mating tests at four density levels and found that large males maintained their mating advantage relative to small males at all densities. Thus, male and female medaka may be similar in body size because large size provides a fecundity advantage for females, as demonstrated in previous studies, and large size provides a mating advantage for males, as demonstrated in our study. Copyright 1998 The Association for the Study of Animal Behaviour. Copyright 1998 The Association for the Study of Animal Behaviour. 相似文献
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CR Divgi AM Scott K McDermott PS Fallone S Hilton K Siler N Carmichael F Daghighian RD Finn AM Cohen 《Canadian Metallurgical Quarterly》1994,21(1):9-15
Ten patients with colorectal cancer metastases received 125I-B72.3 and 131I-CC49 prior to laparotomy (five patients received 1 mg, and five 20 mg of each mAb). Tumor:serum ratios of 131I-CC49 were better than those of 125I-B72.3 (P < 0.01 at 1 mg; P = 0.05 at 20 mg; P < 0.01 at both doses). All known lesions > or = 1 cm in diameter were visualized at the 20 mg dose. There was no difference in absolute tumor uptake of 125I-B72.3 or 131I-CC49. We conclude that mAb CC49 has better relative uptake in colorectal cancers than mAb B72.3. 相似文献
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R Rabinowitz M Barkin JF Schillinger RD Jeffs GT Cook 《Canadian Metallurgical Quarterly》1977,118(3):436-439
Bypass of the left ventricle was accomplished in dogs and the entire circulation was supported temporarily by only the right ventricle. The atrial septum was excised, and the atrium was repartitioned so that the pulmonary veins were in continuity with the right ventricle and the venae cavae were connected through the atrium. Anastomosis of the superior vena cava to the right pulmonary artery brought systemic venous return directly to the lungs. The main pulmonary artery was ligated proximal to the bifurcation, preserving distal confluence of right and left pulmonary arteries. A tubular prosthesis between the proximal pulmonary artery and the aorta connected the right ventricle to the systemic circuit. This procedure, or some modification of the principle, may have clinical feasibility in the treatment of patients with hypoplastic left heart syndrome. 相似文献