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Standard numerical optimization methods become very computational time consuming when dealing with synthesis of array antenna excitation laws, especially when number of elements exceeds a few tenths. Array antenna designer needs a fast and efficient synthesis tool, since the design phase implies several reoptimizations within the definition phase, in order to satisfy tradeoffs on antagonistic requirements : performances, size, cost,… We propose the use of an efficient, from the computational time point of view, and secured, from the convergence point of view, synthesis method illustrated by two examples. The optimized solution satisfies a sta-tionarity condition, which leads to steady solutions in frequency but also with regard to errors (manufacturing, …). Based on analytical calculus performed before any numerical resolution and together with the use of fast Fourier transform algorithms, this method leads to reduced optimization times (in the order of a minute) for arrays of some tenths up to some hundred feeds, computations being performed on a pc. Two theoretical applications are presented and for each of them a computed example is also shown; moreover possible extensions are considered. 相似文献
13.
Microfluidic Manipulation of Core/Shell Nanoparticles for Oral Delivery of Chemotherapeutics: A New Treatment Approach for Colorectal Cancer
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Mohammad Mahdi Hasani‐Sadrabadi Shahrouz Taranejoo Erfan Dashtimoghadam Ghasem Bahlakeh Fatemeh Sadat Majedi Jules John VanDersarl Mohsen Janmaleki Fatemeh Sharifi Arnaud Bertsch Kerry Hourigan Lobat Tayebi Philippe Renaud Karl I. Jacob 《Advanced materials (Deerfield Beach, Fla.)》2016,28(21):4134-4141
14.
Julien Fleureau Karim Bensalah Denis Rolland Olivier Lavastre Nathalie Rioux-Leclercq François Guillé Jean-Jacques Patard Renaud de Crevoisier Lotfi Senhadji 《Expert systems with applications》2011,38(11):14301-14306
In this study, we propose to evaluate the potential of Raman spectroscopy (RS) to assess renal tumours at surgery. Different classes of Raman renal spectra acquired during a clinical protocol are discriminated using support vector machines classifiers. The influence on the classification scores of various preprocessing steps generally involved in RS are also investigated and evaluated in the particular context of renal tumour characterization. Encouraging results show the interest of RS to evaluate kidney cancer and suggest the potential of this technique as a surgical assistance during partial nephrectomy. 相似文献
15.
Sacchi M Spezzani C Carpentiero A Prasciolu M Delaunay R Lüning J Polack F 《The Review of scientific instruments》2007,78(4):043702
We have developed a setup for measuring holographically formed interference patterns using an integrated sample-mask design. The direct space image of the sample is obtained via a two-dimensional Fourier transform of the X-ray diffraction pattern. We present the details of our setup, commenting on the influence of geometrical parameters on the imaging capabilities. As an example, we present and discuss the results of test experiments on a patterned Co film. 相似文献
16.
Jér?me?CourchayEmail author Arnak?S.?Dalalyan Renaud?Keriven Peter?Sturm 《International Journal of Computer Vision》2012,97(1):71-90
A technique for calibrating a network of perspective cameras based on their graph of trifocal tensors is presented. After
estimating a set of reliable epipolar geometries, a parameterization of the graph of trifocal tensors is proposed in which
each trifocal tensor is linearly encoded by a 4-vector. The strength of this parameterization is that the homographies relating
two adjacent trifocal tensors, as well as the projection matrices depend linearly on the parameters. Two methods for estimating
these parameters in a global way taking into account loops in the graph are developed. Both methods are based on sequential
linear programming: the first relies on a locally linear approximation of the polynomials involved in the loop constraints
whereas the second uses alternating minimization. Both methods have the advantage of being non-incremental and of uniformly
distributing the error across all the cameras. Experiments carried out on several real data sets demonstrate the accuracy
of the proposed approach and its efficiency in distributing errors over the whole set of cameras. 相似文献
17.
Chaima Chammakhi Alexandre Boscari Marie Pacoud Grgoire Aubert Haythem Mhadhbi Renaud Brouquisse 《International journal of molecular sciences》2022,23(21)
Drought is an environmental stress that strongly impacts plants. It affects all stages of growth and induces profound disturbances that influence all cellular functions. Legumes can establish a symbiosis with Rhizobium-type bacteria, whose function is to fix atmospheric nitrogen in organs called nodules and to meet plant nitrogen needs. Symbiotic nitrogen fixation (SNF) is particularly sensitive to drought. We raised the hypothesis that, in drought-stressed nodules, SNF inhibition is partly correlated to hypoxia resulting from nodule structure compaction and an increased O2 diffusion barrier, and that the nodule energy regeneration involves phytoglobin–nitric oxide (Pgb–NO) respiration. To test this hypothesis, we subjected faba bean (Vicia faba L.) plants nodulated with a Rhizobium laguerreae strain to either drought or osmotic stress. We monitored the N2-fixation activity, the energy state (ATP/ADP ratio), the expression of hypoxia marker genes (alcohol dehydrogenase and alanine aminotransferase), and the functioning of the Pgb–NO respiration in the nodules. The collected data confirmed our hypothesis and showed that (1) drought-stressed nodules were subject to more intense hypoxia than control nodules and (2) NO production increased and contributed via Pgb–NO respiration to the maintenance of the energy state of drought-stressed nodules. 相似文献
18.
Elodie Mareux Martine Lapalus Amel Ben Saad Renaud Zelli Mounia Lakli Yosra Riahi Marion Almes Manon Banet Isabelle Callebaut Jean-Luc Decout Thomas Falguires Emmanuel Jacquemin Emmanuel Gonzales 《International journal of molecular sciences》2022,23(18)
ABCB11 is responsible for biliary bile acid secretion at the canalicular membrane of hepatocytes. Variations in the ABCB11 gene cause a spectrum of rare liver diseases. The most severe form is progressive familial intrahepatic cholestasis type 2 (PFIC2). Current medical treatments have limited efficacy. Here, we report the in vitro study of Abcb11 missense variants identified in PFIC2 patients and their functional rescue using cystic fibrosis transmembrane conductance regulator potentiators. Three ABCB11 disease-causing variations identified in PFIC2 patients (i.e., A257V, T463I and G562D) were reproduced in a plasmid encoding an Abcb11-green fluorescent protein. After transfection, the expression and localization of the variants were studied in HepG2 cells. Taurocholate transport activity and the effect of potentiators were studied in Madin–Darby canine kidney (MDCK) clones coexpressing Abcb11 and the sodium taurocholate cotransporting polypeptide (Ntcp/Slc10A1). As predicted using three-dimensional structure analysis, the three variants were expressed at the canalicular membrane but showed a defective function. Ivacaftor, GLP1837, SBC040 and SBC219 potentiators increased the bile acid transport of A257V and T463I and to a lesser extent, of G562D Abcb11 missense variants. In addition, a synergic effect was observed when ivacaftor was combined with SBC040 or SBC219. Such potentiators could represent new pharmacological approaches for improving the condition of patients with ABCB11 deficiency due to missense variations affecting the function of the transporter. 相似文献
19.
Claire Monge Camille Ayad Anne-Lise Paris Renaud Rovera Evelyne Colomb Bernard Verrier 《International journal of molecular sciences》2022,23(21)
Among mucosal administration routes for vaccines, the sublingual route has been proven capable of inducing a potent systemic and mucosal immune response. However, the absence of a simple and compliant delivery system and the lack of robust mucosal adjuvants impede the development of sublingual vaccines. Here, we describe a mucoadhesive patch made of a layer-by-layer assembly of polysaccharides, chitosan, and hyaluronic acid. The mucoadhesive patch was covered by adjuvanted nanoparticles carrying viral proteins. We showed that the nanoparticles effectively cross the outer layers of the sublingual mucosa to reach the epithelium. Furthermore, the encapsulated adjuvants, 3M-052 and mifamurtide, targeting toll-like receptor (TLR) 7/8 and nucleotide-binding oligomerization domain-2 (NOD2), respectively, remain fully active after encapsulation into nanoparticles and exhibit a cytokine/chemokine signature similar to the mucosal gold-standard adjuvant, the cholera toxin. However, the particulate adjuvants induced more moderate levels of proinflammatory interleukin (IL)-6 and keratinocyte chemoattractant (KC), suggesting a controlled activation of the innate immune response. 相似文献