An adaptive finite element scheme to solve fluid-structure vibration problems on non-matching grids

This paper deals with the computation of the vibration modes of a system consisting of a linear elastic solid interacting with an acoustic fluid. A finite element method based on meshes for each medium not matching on the fluid-solid interface is analyzed. Optimal order of convergence is proved for the approximation of the eigenfunctions, as well as a double order for the eigenvalues. Numerical tests confirming the theoretical results and showing the advantage of using non-matching grids are reported. Finally, an a posteriori error estimator for this method is introduced and combined with a mesh refinement strategy. The efficiency of this adaptive technique is tested with further numerical experiments. Received: 30 January 2001 / Accepted: 30 May 2001     

A computational literature review of football performance analysis through probabilistic topic modeling

This research aims to illustrate the potential use of concepts, techniques, and mining process tools to improve the systematic review process. Thus, a review was performed on two online databases (Scopus and ISI Web of Science) from 2012 to 2019. A total of 9649 studies were identified, which were analyzed using probabilistic topic modeling procedures within a machine learning approach. The Latent Dirichlet Allocation method, chosen for modeling, required the following stages: 1) data cleansing, and 2) data modeling into topics for coherence and perplexity analysis. All research was conducted according to the standards of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses in a fully computerized way. The computational literature review is an integral part of a broader literature review process. The results presented met three criteria: (1) literature review for a research area, (2) analysis and classification of journals, and (3) analysis and classification of academic and individual research teams. The contribution of the article is to demonstrate how the publication network is formed in this particular field of research, and how the content of abstracts can be automatically analyzed to provide a set of research topics for quick understanding and application in future projects.

     

Hedgehog Signalling Modulates Immune Response and Protects against Experimental Autoimmune Encephalomyelitis

The Hedgehog (Hh) pathway is essential for the embryonic development and homeostatic maintenance of many adult tissues and organs. It has also been associated with some functions of the innate and adaptive immune system. However, its involvement in the immune response has not been well determined. Here we study the role of Hh signalling in the modulation of the immune response by using the Ptch-1-LacZ^+/− mouse model (hereinafter referred to as ptch^+/−), in which the hemizygous inactivation of Patched-1, the Hh receptor gene, causes the constitutive activation of Hh response genes. The in vitro TCR stimulation of spleen and lymph node (LN) T cells showed increased levels of Th2 cytokines (IL-4 and IL-10) in ptch^+/−cells compared to control cells from wild-type (wt) littermates, suggesting that the Th2 phenotype is favoured by Hh pathway activation. In addition, CD4⁺ cells secreted less IL-17, and the establishment of the Th1 phenotype was impaired in ptch^+/− mice. Consistently, in response to an inflammatory challenge by the induction of experimental autoimmune encephalomyelitis (EAE), ptch^+/− mice showed milder clinical scores and more minor spinal cord damage than wt mice. These results demonstrate a role for the Hh/ptch pathway in immune response modulation and highlight the usefulness of the ptch^+/− mouse model for the study of T-cell-mediated diseases and for the search for new therapeutic strategies in inflammatory diseases.     

Multicompartment Tubular Micromotors Toward Enhanced Localized Active Delivery

A tubular micromotor with spatially resolved compartments is presented toward efficient site-specific cargo delivery, with a back-end zinc (Zn) propellant engine segment and an upfront cargo-loaded gelatin segment further protected by a pH-responsive cap. The multicompartment micromotors display strong gastric-powered propulsion with tunable lifetime depending on the Zn segment length. Such propulsion significantly enhances the motor distribution and retention in the gastric tissues, by pushing and impinging the front-end cargo segment onto the stomach wall. Once the micromotor penetrates the gastric mucosa (pH ≥ 6.0), its pH-responsive cap dissolves, promoting the autonomous localized cargo release. The fabrication process, physicochemical properties, and propulsion behavior are systematically tested and discussed. Using a mouse model, the multicompartment motors, loaded with a model cargo, demonstrate a homogeneous cargo distribution along with approximately four-fold enhanced retention in the gastric lining compared to monocompartment motors, while showing no apparent toxicity. Therapeutic payloads can also be loaded into the pH-responsive cap, in addition to the gelatin-based compartment, leading to concurrent delivery and sequential release of dual cargos toward combinatorial therapy. Overall, this multicompartment micromotor system provides unique features and advantages that will further advance the development of synthetic micromotors for active transport and localized delivery of biomedical cargos.     

A socially inspired energy feedback technology: challenges in a developing scenario

Raising awareness of the environmental impact of energy generation and consumption has been a recent concern of contemporary society worldwide. Underlying the awareness of energy consumption is an intricate network of perception and social interaction that can be mediated by technology. In this paper we argue that issues regarding energy, environment and technology are very much situated and involve tensions of sociocultural nature. This exploratory investigation addresses the subject by introducing the design of a Socially-inspired Energy Eco-Feedback Technology (SEET), which is composed of an interactive system to trigger and mediate collective savings and a tangible device as a public feedback. Results of an evaluation situated in the context of a school in a socially disadvantaged area in Brazil are discussed, shedding light on the sociocultural aspects related to the subject. The role of the SEET to motivate energy awareness collectively among the social group is assessed, as well as the design characteristics that contributed to that. Outcomes bring to light social aspects and dynamics that would hardly have been predicted, evidencing critical factors related to a socially inspired design approach in the energy awareness domain.     

Integrating optimisation and simulation approaches for daily scheduling of assembly and test operations

The purpose of this paper is to show how the results of an optimisation model that can be integrated with the decisions made within a simulation model to schedule back-end operations in a semiconductor assembly and test facility. The problem is defined by a set of resources that includes machines and tooling, process plans for each product and the following four hierarchical objectives: minimise the weighted sum of key device shortages, maximise weighted throughput, minimise the number of machines used and minimise the makespan for a given set of lots in queue. A mixed integer programming model is purposed and first solved with a greedy randomised adaptive search procedure (GRASP). The results associated with the prescribed facility configuration are then fed to the simulation model written in AutoSched AP. However, due to the inadequacy of the options built into AutoSched, three new rules were created: the first two are designed to capture the machine set-up profiles provided by the GRASP and the third to prioritise the processing of hot lots containing key devices. The computational analysis showed that incorporating the set-up from the GRASP in dynamic operations of the simulation greatly improved its performance with respect to the four objectives.     

Anatomy and behaviour of a post-eruptive rain lahar triggered by a typhoon on Mayon volcano,Philippines

Mayon Volcano in the Philippines, one the world's most active, is situated in a moist, tropical-maritime climate with frequent typhoons. A third of Mayon's eruptions generate destructive lahars (volcanic debris flows and hyperconcentrated streamflows). Lahars also occur during quiescent periods when monsoons and typhoons deliver rains of appropriate intensity and duration to the loose debris on the volcano slopes. Both eruption- and post-eruptive lahars occur most frequently during the typhoon-prone October–December season of the Northeast Monsoon. Post-eruptive lahars, the most poorly documented, are exemplified by a debris-flow event triggered by Saling, a typhoon of only moderate intensity, that occurred in Mabinit Channel on the southeast Mayon flank on October 17–18, 1985, one year after the last Mayon eruption. Detailed pre- and post-Saling surveys docment channel deepening of up to 4 m and maximum lateral erosion of 66 m. The debris flows left prominent, discontinuous multi-level terraces along the length of Mabinit Channel, either from pulsations due to temporary channel blockage, or as levee deposits. A significant volume of debris overtopped channel bends at 250–200 m elevations, coalescing to cover a 200,000 m² area of 4.5° slope with bouldery lateral deposits 1 m thick on the average. Channelized flows below this level plugged 0.5 km of the original channel and replaced it with a new conduit of comparable size. The Saling debris-flow deposits have a remarkably uniform sand-silt mode and less prominent, more variable modes in the pebble-boulder range. Shear strengths of the lateral flows ranged from 0.46×10⁴ to 2.32×10⁴ dn cm^?2; those of the channelized flows at the plug were significantly higher. Reconstructed flow velocity was 3.8 m sec^?1.     

A combinatorial approach to the generalized Baker–Campbell–Hausdorff–Dynkin formula

The aim of this paper is to obtain an explicit expression, instead of using a recursive method, for the nth term coefficient of the generalized Baker–Campbell–Hausdorff–Dynkin (gBCHD) formula. The gBCHD formula has been applied to control theory, specially to nonholonomic motion planning.     

Platform designer: An approach for modeling multiprocessor platforms based on SystemC

This paper[3.5pc] presents the Platform Designer (PD) framework, a set of SystemC based tools that provide support for modeling, simulation and analysis of multiprocessor SoC platforms (MPSoC), at different abstraction levels. PD provides mechanisms for interconnection specification, process synchronization and communication, thus allowing the modeling of a complete platform, in a unified environment. To do that it uses an extension of the ArchC ADL and acsys, a tool that enables the automatic generation of a SystemC simulator of the platform. The main advantages of this approach are twofold. First, designers have more flexibility since they can integrate and configure different processors to the platform, using a single environment. Second, it enables a faster design space exploration, given that it automatically generates SystemC simulators of whole platforms at distinct abstraction levels. A number of platform variations can be tried out with minor design changes, thus reducing design time. Experimental results show the suitability of the platform simulator for design space exploration. Real applications (with medium complexity) run in the platform in few minutes. Combined with the facility to generate platforms with minor changes, this feature allows an improvement of the design space exploration.