Towards van der Waals Epitaxial Growth of GaAs on Si using a Graphene Buffer Layer

Van der Waals growth of GaAs on silicon using a two‐dimensional layered material, graphene, as a lattice mismatch/thermal expansion coefficient mismatch relieving buffer layer is presented. Two‐dimensional growth of GaAs thin films on graphene is a potential route towards heteroepitaxial integration of GaAs on silicon in the developing field of silicon photonics. Hetero‐layered GaAs is deposited by molecular beam epitaxy on graphene/silicon at growth temperatures ranging from 350 °C to 600 °C under a constant arsenic flux. Samples are characterized by plan‐view scanning electron microscopy, atomic force microscopy, Raman microscopy, and X‐ray diffraction. The low energy of the graphene surface and the GaAs/graphene interface is overcome through an optimized growth technique to obtain an atomically smooth low­ temperature GaAs nucleation layer. However, the low adsorption and migration energies of gallium and arsenic atoms on graphene result in cluster‐growth mode during crystallization of GaAs films at an elevated temperature. In this paper, we present the first example of an ultrasmooth morphology for GaAs films with a strong (111) oriented fiber‐texture on graphene/silicon using quasi van der Waals epitaxy, making it a remarkable step towards an eventual demonstration of the epitaxial growth of GaAs by this approach for heterogeneous integration.     

Atmospheric correction over land for MERIS

A three-stage atmospheric correction is proposed for the Medium Resolution Imaging Spectrometer (MERIS) from a validated formulation of the signal. We correct first for the gaseous transmittance. Assuming the ozone correction is well defined, we illustrate the need to include a correction for water vapour continuum which covers most of the MERIS bands. The water vapour transmittance can be computed from the water vapour content obtained from a twoband ratio at 900nm and 890nm. We demonstrate that a direct association between the transmittance in a given band and the two band ratio is more accurate due to the removal of the coupling between absorption and scattering. Secondly, the Rayleigh correction depends on the barometric pressure determined here from a two band ratio method with the oxygen A band. Good accuracy is obtained for the pressure when accounting for the coupling between scattering and gas absorption, which mostly depends on the surface reflectance. The Rayleigh reflectance is computed from a Fourier series decomposition in which primary scattering is corrected for multiple scattering by a multiplicative factor which is derived from a polynomial regression versus the optical thickness. A similar formulation of the signal is proposed for the aerosol reflectances from 12 predefined aerosol models. The aerosol correction relies on a characterization of the aerosol over Dense Dark Vegetation for which an identification criteria is proposed along with standard reflectance values in the blue and in the red.     

Simulation-based conjoint ranking for optimal decision support process under aleatory uncertainty

Design chain management requires many decision makers throughout the product development process. It is critical to reduce complexity and uncertainty of the design process by correctly modeling subjective data associated with decision makers’ preferences. This paper aims at using decision support to find optimal designs by modeling respondent preferences and trade-offs with consideration of uncertainty. Specifically, a simulation-based ranking methodology is implemented and incorporated with traditional conjoint analysis. This process facilitates a schematic decision support process by alleviating user fatigue. In addition, incorporation of uncertainty in the ranking process provides the capability of producing robust and reliable products. The efficacy and applicability of simulation-based conjoint ranking is demonstrated with a case study of a power-generating shock absorber design.     

Researchers on the pier: Academics’ use of a local internet gateway

This paper describes the establishment of an Internet gateway local to the University of Sussex, firstly as a Gopher and more recently as a World Wide Web server. There follows an account of a project currently underway to assess the practical value of Internet resources to research and the consequential training and support requirements. This assessment is planned to determine the value of a local gateway to academic researchers at Sussex and the roles specific to a local gateway that such comprehensive resources as Yahoo and BUBL cannot fulfil. The project is using an interview‐based methodology to gain an understanding of researchers’ views of Internet resource provision, and these interviews are being analysed with the help of the NUD*IST qualitative data analysis software package. The account is of research in progress, and hence does not conclude with the set of pragmatic policy proposals that forms its key objective. Instead, some indication is given of the broad early findings of the project     

Visual analysis of social networks in space and time using smartphone logs

We designed and applied interactive visualisation techniques for investigating how social networks are embedded in time and space, using data collected from smartphone logs. Our interest in spatial aspects of social networks is that they may reveal associations between participants missed by simply making contact through smartphone devices. Four linked and co-ordinated views of spatial, temporal, individual and social network aspects of the data, along with demographic and attitudinal variables, helped add context to the behaviours we observed. Using these techniques, we were able to characterise spatial and temporal aspects of participants’ social networks and suggest explanations for some of them. This provides some validation of our techniques.Unexpected deficiencies in the data that became apparent prompted us to evaluate the dataset in more detail. Contrary to what we expected, we found significant gaps in participant records, particularly in terms of location, a poorly connected sample of participants and asymmetries in reciprocal call logs. Although the data captured are of high quality, deficiencies such as these remain and are likely to have a significant impact on interpretations relating to spatial aspects of the social network. We argue that appropriately-designed interactive visualisation techniques–afforded by our flexible prototyping approach–are effective in identifying and characterising data inconsistencies. Such deficiencies are likely to exist in other similar datasets, and although the visual approaches we discuss for identifying data problems may not be scalable, the categories of problems we identify may be used to inform attempts to systematically account for errors in larger smartphone datasets.     

A three-dimensional microfluidic tumor cell migration assay to screen the effect of anti-migratory drugs and interstitial flow

Most anti-cancer drug screening assays are currently performed in two dimensions, on flat, rigid surfaces. However, there are increasing indications that three-dimensional (3D) platforms provide a more realistic setting to investigate accurate morphology, growth, and sensitivity of tumor cells to chemical factors. Moreover, interstitial flow plays a pivotal role in tumor growth. Here, we present a microfluidic 3D platform to investigate behaviors of tumor cells in flow conditions with anti-migratory compounds. Our results show that interstitial flow and its direction have significant impact on migration and growth of hepatocellular carcinoma cell lines such as HepG2 and HLE. In particular, HepG2/HLE cells tend to migrate against interstitial flow, and their growth increases in interstitial flow conditions regardless of the flow direction. Furthermore, this migratory activity of HepG2 cells is enhanced when they are co-cultured with human umbilical vein endothelial cells. We also found that migration activity of HepG2 cells attenuates under hypoxic conditions. In addition, the effect of Artemisinin, an anti-migratory compound, on HepG2 cells was quantitatively analyzed. The microfluidic 3D platform described here is useful to investigate more accurately the effect of anti-migratory drugs on tumor cells and the critical influence of interstitial flow than 2D culture models.     

Computer Simulation of a Living Cell: Metabolic Control System Experiments

Abstract

This paper reports on some interesting experiments performed on a simulated model of a living cell. The basic model is that of Weinberg [35] and the underlying techniques employed are described by Zeigler and Weinberg [41]. The cell was subjected to step changes in its nutrient environment.     

Increased sensitivity for the diagnosis of Taenia saginata cysticercus infection by additional heart examination compared to the EU-approved routine meat inspection

In spite of the statutory meat inspection at abattoirs, Taenia saginata cysticercus infection in cattle remains an economically important parasitic disease for the livestock industry by affecting food safety. The routinely performed standard meat inspection protocol has a low diagnostic sensitivity for the detection of T. saginata cysticerci infections. Therefore, an abattoir trial aiming to increase the detection level was undertaken. In three EU-approved abattoirs, several additional heart incisions were performed in a total of 1088 slaughtered cattle originating from 832 farms throughout Switzerland. Cysticerci as putative parasitic lesions were classified by visual examination during meat inspection and confirmed microscopically and/or by molecular analyses. With the EU-approved routine meat inspection, bovine cysticercosis was diagnosed in 1.8% (20/1088) of the slaughtered animals. Additional incisions into the heart muscle revealed a further 29 cases, indicating that the prevalence was at least 4.5%. All infected animals originated from individual farms. This straightforward technique had a significantly higher sensitivity and is feasible for routine practice. It also confirms that the prevalence of this zoonotic parasite in the cattle population is underestimated based on the routine abattoir reports.     

Efficient Non-Malleable Commitment Schemes

Non-malleability protects against man-in-the middle attacks on cryptographic protocols. Non-malleable commitment schemes, for example, assure that a commitment of a message does not help to produce a commitment of a related message. Here we present efficient constructions of such commitment schemes in the common reference string model based on standard assumptions such as RSA, factoring, or discrete logarithm. Our protocols require only three rounds and a few modular exponentiations, and provide statistical or even perfect secrecy of committed values.     

Learning psychotherapy in the digital age.

There is substantial literature documenting the process factors that lead to effective psychotherapy. Similarly, there is now a wealth of data attesting to the effectiveness of several psychotherapy brands. Little is known about the elements that facilitate learning how to be an effective clinician. One important step, after reading about a treatment model and seeing techniques demonstrated, is having the chance to practice the approach and receiving feedback and coaching from an experienced, knowledgeable supervisor. To accomplish this efficiently, most programs rely not only on trainee accounts of what went on in their therapy sessions, but also on recordings and videos of therapeutic encounters. This article describes our experience over a 5-year period in developing the use of Webcams for training psychology interns and psychiatric residents in the delivery of psychotherapy services. Pragmatic and technical details are given about how we went about establishing a recording system that is easy to use and provides secure, confidential storage of information at a reasonable cost. Discussion addresses both the weighing of choices that need to be made and overcoming the hesitation of trainees to reveal their work during treatment sessions. (PsycINFO Database Record (c) 2011 APA, all rights reserved)