From virtual worlds to the therapist's office

The increasing recognition of the importance of emotional state in both disease and health makes imperative the need for health care providers to evaluate the psychological status of patients. In primary care medical practice, between 30 and 60% of complaints prompting visits to the physician's office have a significant emotional component. In addition, rates of depressive illness are estimated to be as high as 20% in the general population. Prompt recognition of anxiety, depression, personality disorder, and psychosis is important for correct interpretation of historical and physical findings during examination and evaluation of patients. The establishment of a caring and trusting relationship is crucial so that patients can comfortably express concerns, and so that a discussion leading to an agreeable therapeutic plan can be decided upon. This process has traditionally taken place in the one-on-one format between the health care provider and patient. Many physicians and therapists are interested in exploring whether virtual reality can augment the therapeutic process, and thus improve diagnostic capabilities     

ST/b and DBA/2 mice differ in brain alpha-bungarotoxin binding and alpha 7 nicotinic receptor subunit mRNA levels: a quantitative autoradiographic analysis

Inbred mouse strains vary in sensitivity to a number of behavioral and physiological effects produced by nicotine. Differences in sensitivity to nicotine are correlated with variance in the number of brain nicotinic receptors as measured in regionally dissected brain tissue. The studies reported here used quantitative autoradiography and in-situ hybridization methods to measure regional levels of alpha-bungarotoxin (alpha BTX) binding and alpha 7 mRNA levels. Two inbred mouse strains, ST/b and DBA/2, were compared because these strains differ maximally in sensitivity to nicotine-induced seizures and in alpha BTX binding measured in regional brain homogenates. The binding of alpha BTX was significantly greater in the St/b strain in 42 of 127 brain regions that were analyzed, and a trend towards increased binding was seen in many additional brain regions. The most consistent strain differences were found in hippocampal, thalamic and pontine nuclei. Strain differences in alpha 7 mRNA levels were also detected, but these were not as widespread as were the alpha BTX binding differences. The alpha 7 mRNA levels were significantly correlated with alpha BTX binding in both mouse strains which suggests that the strain differences in binding are related, in part, to the levels of alpha 7 mRNA.     

Effect of rotation on the structure of a convecting mushy layer

Summary Nonlinear natural convection in a mushy layer during solidification of a binary alloy is investigated under a high gravity environment where the rotation axis is inclined to the high gravity vector. Asymptotic and scaling analyses are applied to convective flow within the mushy layer and in vertical chimneys. The main result is that, for some particular moderate rotation range, vertical velocity in the chimneys decreases rapidly with increasing rotation rate and appears to have opposite signs across some rotation dependent vertical level.     

Vitamin C Spray Drying: Study of the Thermal Constraint

Temperature variation in the spray drying method has no effect on the ascorbic acid molecule. No chemical interaction between the colloidal silica and the ascorbic acid could be determined, but a physicochemical interaction “absorption” was determined. Colloidal silica improved the final yield of spray drying in proportion to its concentration. No polymorphic forms could be determined in the spray-dried ascorbic acid. Drug release from the ascorbic acid spray dried was found to be dependent on the Aerosil content: highest release rates were obtained with Aerosil.     

Harvesting Wiki Consensus: Using Wikipedia Entries as Vocabulary for Knowledge Management

Vocabularies that provide unique identifiers for conceptual elements of a domain can improve precision and recall in knowledge-management applications. Although creating and maintaining such vocabularies is generally hard, wiki users easily manage to develop comprehensive, informal definitions of terms, each one identified by a URI. Here, the authors show that the URIs of Wikipedia entries are reliable identifiers for conceptual entities. They also demonstrate how Wikipedia entries can be used for annotating Web resources and knowledge assets and give precise estimates of the amount of Wikipedia URIs in terms of the popular Proton ontology's top-level concepts.     

A Simulation Environment for e-Learning in Digital Design

Deeds is a simulation environment for e-learning in digital electronics. The simulators cover combinational and sequential logic networks, finite state-machine design, and microcomputer interfacing and programming. They are integrated together, and therefore allow the design and test of embedded digital systems. The environment guides students' activities by delivering learning materials through specialized browsers. An extensive collection of learning materials is available. This paper includes an example of activity on a problem assignment.     

A structure/function study of polyaminoamide dendrimers as silica scale growth inhibitors

Dendrimers have attracted immense attention during the last decade due to their interesting properties both from a basic and an applied research viewpoint. Encapsulation of metal nanoparticles for catalysis, drug delivery and light harvesting are only some applications of dendrimers that are breaking new ground. A novel application of dendrimer technology is described in the present paper that relates to industrial water treatment. Industrial water systems often suffer from undesirable inorganic deposits. These can form either in the bulk or on metallic surfaces, such as heat exchangers or pipelines. Silica (SiO₂) scale formation and deposition is a major problem in high‐silica‐containing cooling waters. Scale prevention rather than removal is highly desired. In this paper, benchtop screening tests on various silica inhibition chemistries are reported, with emphasis on materials with a dendrimeric structure. Specifically, the inhibition properties of commercially available STARBURST^® polyaminoamide (PAMAM) dendrimers generations 0.5, 1, 1.5, 2, and 2.5 are investigated in detail together with other commonly‐used scale inhibitors. Experimental results show that inhibition efficiency largely depends on structural features of PAMAM dendrimers such as generation number and nature of the end groups. PAMAM dendrimers are effective inhibitors of silica scale growth at 40 ppm dosage levels. PAMAM dendrimers also act as silica nucleators, forming SiO₂–PAMAM composites. This occurs because the SiO₂ formed by incomplete inhibition interacts with cationic PAMAM‐1 and ‐2. The general scope of silica formation and inhibition in industrial waters is also discussed. Copyright © 2005 Society of Chemical Industry