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31.
The effect of small dose of topiroxostat on serum uric acid in patients receiving hemodialysis 下载免费PDF全文
Yume Nagaoka Yoshiko Tanaka Hiroshi Yoshimoto Rie Suzuki Kakei Ryu Mio Ueda Minako Akiyama Miho Nagai Yoshitaka Miyaoka Eiichiro Kanda Shinnichi Iwai Michio Nagaoka Yoshihiko Kanno 《Hemodialysis international. International Symposium on Home Hemodialysis》2018,22(3):388-393
Introduction : Topiroxostat, a recently developed xanthine oxidase inhibitor, is expected to have fewer adverse effects than allopurinol because it has different mechanism of action from alloprinol. However, its dosage, usage and safety have not been established in patients with impaired renal function or those undergoing dialysis at the development since no studies was conducted in these patients. Methods : Cross over clinical trial using 3 months of allopurinol and topiroxostat on 27 maintain Japanese HD patients were carried out. The effects on oxidative stress status of both drugs were also evaluated by measuring oxidation reduction potential. Findings : Twenty‐five of twenty‐seven patients completed study. The mean serum uric acid levels in the topiroxostat‐treated arm was significantly lower than it in the allopurinol‐treated arm time‐dependently (P < 0.0001). Corrected oxidative stress ratio defined as biological antioxidant potential/diacron reactive oxygen metabolites was significantly increased in topiroxostat‐arm (*P = 0.0035), but not in allopurinol‐arm (P = 0.1429). No significant difference was seen in diacron reactive oxygen metabolites, biological antioxidant potential, static oxidation‐reduction potential, and capacity oxidation‐reduction potential between pre and post treatment of both drugs. Discussion : It is suggested that a low dose of topiroxostat decreased serum uric acid sufficiently to maintain it below 7.0 mg/dL in patients receiving hemodialysis. 相似文献
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Ryoji Katoh Masakuni OzawaYoshitaka Ino Akira Kagohashi 《Journal of the European Ceramic Society》2011,31(14):2441-2445
The morphology of CuO powders formed by a homogeneous precipitation process from aqueous copper precursor complex was investigated. The effect of 2.45 GHz microwave irradiation appeared in the characteristic morphology of the CuO microcrystal with comparison of an ordinal synthesis process. The crystallographic orientation of CuO microcrystals in the particle was examined by HRTEM. Using microwave irradiation, it was demonstrated that the morphology of the particles was kept through the decomposition of the precursor. Also the rapid transformation of a precursor to CuO in aqueous solution under microwave irradiation condition was discussed. 相似文献
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Yusuke Soraji Kazuo Furuta Taro Kanno Hisae Aoyama Satoru Inoue Daisuke Karikawa Makoto Takahashi 《Cognition, Technology & Work》2012,14(2):93-105
Since controller teams are in charge of en-route air traffic control, team cooperation is a key issue for good control performance. We conducted ethnographic field observation at the Tokyo Area Control Center and then analyzed the obtained data to develop a cognitive model of team cooperation in en-route air traffic control. We segmented conversational records, behavioral records, and so on by control unit, and then clarified relations between the segments and identified expert knowledge and judgment behind them. Cognitive processes of controller teams were reconstructed based on a concept of distributed cognition. The analysis revealed that the mutual belief model is applicable to team cooperation processes, the role assignment of tasks within a controller team is implicit and that control plans are implemented smoothly once team situation awareness has been established. A cognitive model of controllers?? team cooperation has been constructed based on these findings. 相似文献
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Yoshiki Yamashita Kazunari Shima Ikuo Kanno Masahiko Ohtaka Makoto Hashimoto Kuniaki Ara 《Journal of Nuclear Science and Technology》2013,50(1):91-97
X-ray computed tomography (CT) with iodine contrast agent is widely employed to locate cancers. However, this method has shortcomings such as high-radiation dose exposure, iodine side effects, and a beam hardening effect. We have been working on the energy-resolved CT measurement method using a novel X-ray detection system, the “transXend” detector, which measures X-rays as electric currents and gives the energy distribution of incident X-rays after analysis. In the present study, we propose a method for low-dose exposure CT that involves the combination of the energy-resolved CT method, which is free from the beam hardening effect, and a harmless contrast agent with high-energy K-edge absorption, such as gold nanoparticles expected as a future contrast agent. Comparisons of radiation dose exposures as functions of aluminum filter thickness at the exit aperture of an X-ray tube and the K-edge energies of contrast agents are described. 相似文献
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Ryo Watada Makoto Ohsaki Yoshihiro Kanno 《Structural and Multidisciplinary Optimization》2011,43(4):459-471
Uniqueness and symmetry of solution are investigated for topology optimization of a symmetric continuum structure subjected
to symmetrically distributed loads. The structure is discretized into finite elements, and the compliance is minimized under
constraint on the structural volume. The design variables are the densities of materials of elements, and intermediate densities
are penalized to prevent convergence to a gray solution. A path of solution satisfying conditions for local optimality is
traced using the continuation method with respect to the penalization parameter. It is shown that the rate form of the solution
path can be formulated from the optimality conditions, and the uniqueness and bifurcation of the path are related to eigenvalues
and eigenvectors of the Jacobian of the governing equations. This way, local uniqueness and symmetry breaking process of the
solution are rigorously investigated through the bifurcation of a solution path. 相似文献
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Toshiyuki Akazawa Kohji Itabashi Masaru Murata Tomoya Sasaki Junichi Tazaki Makoto Arisue Masayoshi Kobayashi Tohru Kanno 《Journal of the American Ceramic Society》2005,88(12):3545-3548
Bioresorbable and functionally graded apatites (fg-HAp) ceramics, which are characterized by gradations in crystallinity and the grain size of hydroxyapatite (HAp:Ca10 (PO4 )6 (OH)2 ), were designed using bovine bone by the calcination and partial dissolution–precipitation method. The fg-HAp ceramics had macropores of 100–600 μm originated from spongy bone, and micropores of 10–160 nm. Fg-HAp ceramics loaded with recombinant human bone morphogenetic protein-2 (rhBMP-2/fg-HAp) were implanted into the subcutaneous tissue of rats. Eight weeks after the implantation, the surface and bulk degradations of the fg-HAp-containing body fluid occured, and small pieces of fg-HAp were incorporated into the induced bone and fatty marrow, suggesting that osteoinduction occurred in conjunction with bone remodeling. The rhBMP-2/fg-HAp ceramics developed could become a resorbable biomimetic material with fast bioresorption and osteoinduction characteristics. 相似文献
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In order to solve the problem of particles settling and agglomeration in front of solidifying interface in unidirectional solidification (UDS) experiments, a zone-melted process has been utilized in this study. The experimental results show that, the melting zone could be kept in 30–40 mm width and the zone melted UDS experiments are realized with Al2O3 particle reinforced aluminum-matrix composites. But particle settling still occurs in the liquid, and becomes severe as the particle volume fraction decreases. However, when the volume fraction of the particles is more than 20–22 vol.%, no further settling occurs under a solidification rate of 8–16 mm/h. Investigation on the interaction of particles and solid/liquid interface reveals that the Al2O3 particles are rejected into liquid and pushed by the growing solid phase in Al2O3(P)/Al and Al2O3(P)/Al-0.23wt.%Ce composites. Some particles are mechanically entrapped between cells, and distributed along the crystal grain boundaries. 相似文献