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排序方式: 共有3103条查询结果,搜索用时 15 毫秒
51.
Sebastian Klenk Jürgen Dippon Peter Fritz Gunther Heidemann 《Information Systems Frontiers》2009,11(4):391-403
Medical data mining is currently actively pursued in computer science and statistical research but not in medical practice.
The reasons therefore lie in the difficulties of handling and statistically analyzing medical data. We have developed a system
that allows practitioners in the field to interactively analyze their data without assistance of statisticians or data mining
experts. In the course of this paper we will introduce data mining of medical data and show how this can be achieved for survival
data. We will demonstrate how to solve common problems of interactive survival analysis by presenting the Online Clinical
Data Mining (OCDM) system. Thereby the main focus is on similarity based queries, a new method to select similar cases based
on their covariables and the influence of these on their survival. 相似文献
52.
The current Web Services Agreement specification draft proposes a simple request-response protocol for agreement creation
only addressing bilateral offer exchanges. This paper proposes a framework augmenting this WS-Agreement to enable negotiations
according to a variety of bilateral and multilateral negotiation protocols. The framework design is based on a thorough analysis
of taxonomies for negotiations from the literature in order to allow for capturing a variety of different negotiation models
within a single, WS-Agreement compatible, framework. In order to provide for the intended flexibility, the proposed protocol
takes a two-stage approach: a meta-protocol is conducted among interested parties to agree on a common negotiation protocol
first before the real negotiation is carried out in the second step due to the protocol established in the first step. 相似文献
53.
Sebastian Ronneberger Junfang Zhang Yuxin Liu Felix F. Loeffler 《Advanced functional materials》2023,33(17):2210116
Tagging, tracking, or validation of products are often facilitated by inkjet-printed optical information labels. However, this requires thorough substrate pretreatment, ink optimization, and often lacks in printing precision/resolution. Herein, a printing method based on laser-driven deposition of solid polymer ink that allows for printing on various substrates without pretreatment is demonstrated. Since the deposition process has a precision of <1 µm, it can introduce the concept of sub-positions with overlapping spots. This enables high-resolution fluorescent labels with comparable spot-to-spot distance of down to 15 µm (444,444 spots cm−2) and rapid machine learning-supported readout based on low-resolution fluorescence imaging. Furthermore, the defined thickness of the printed polymer ink spots can be used to fabricate multi-channel information labels. Additional information can be stored in different fluorescence channels or in a hidden topography channel of the label that is independent of the fluorescence. 相似文献
54.
Akesson Benny Nasri Mitra Nelissen Geoffrey Altmeyer Sebastian Davis Robert I. 《Real-Time Systems》2022,58(3):358-398
Real-Time Systems - This paper presents results and observations from a survey of 120 industry practitioners in the field of real-time embedded systems. The survey provides insights into the... 相似文献
55.
Bioimaging: Shaping Luminescent Properties of Yb3+ and Ho3+ Co‐Doped Upconverting Core–Shell β‐NaYF4 Nanoparticles by Dopant Distribution and Spacing (Small 47/2017) 下载免费PDF全文
56.
Małgorzata Misiak Michał Skowicki Tomasz Lipiński Agnieszka Kowalczyk Katarzyna Prorok Sebastian Arabasz Artur Bednarkiewicz 《Nano Research》2017,10(10):3333-3345
Versatile optimization of the synthesis method and composition of Yb3+ and Tm3+ co-doped CaF2 nanoparticles as well as a novel biofunctionalization method were developed and evaluated.Through multistep synthesis,the luminescence intensity of the Tm3+ activator was enhanced by more than 10-fold compared to standard one-step synthesis.The proposed methods were used to homogenously distribute the doping ions within the nanoparticle's volume and thus reduce luminescence quenching.Optimization of dopant ions concentration led to the selection of the most efficient visible and near-infrared up-converting nanoparticles,which were CaF2 doped with 10% Yb3+ 0.05% Tm3+ and 20% Yb3+ 0.5% Tm3+,respectively.To illustrate the suitability of the synthesized nanoparticles as bio-labels,a dedicated biofunctionalization method was used,and the nanoparticles were applied for labeling and imaging of Candida albicans cells.This method shows great promise because of extremely low background and high specificity because of the presence of the attached molecules. 相似文献
57.
Hector Archila Sebastian Kaminski David Trujillo Edwin Zea Escamilla Kent A. Harries 《Materials and Structures》2018,51(4):102
The use of small diameter whole-culm (bars) and/or split bamboo (a.k.a. splints or round strips) has often been proposed as an alternative to relatively expensive reinforcing steel in reinforced concrete. The motivation for such replacement is typically cost—bamboo is readily available in many tropical and sub-tropical locations, whereas steel reinforcement is relatively more expensive—and more recently, the drive to find more sustainable alternatives in the construction industry. This review addresses such ‘bamboo-reinforced concrete’ and assesses its structural and environmental performance as an alternative to steel reinforced concrete. A prototype three bay portal frame, that would not be uncommon in regions of the world where bamboo-reinforced concrete may be considered, is used to illustrate bamboo reinforced concrete design and as a basis for a life cycle assessment of the same. The authors conclude that, although bamboo is a material with extraordinary mechanical properties, its use in bamboo-reinforced concrete is an ill-considered concept, having significant durability, strength and stiffness issues, and does not meet the environmentally friendly credentials often attributed to it. 相似文献
58.
On the Structure of Amorphous Mesoporous Silica Nanoparticles by Aberration‐Corrected STEM 下载免费PDF全文
Sebastian Calderon V Tânia Ribeiro José Paulo S. Farinha Carlos Baleizão Paulo J. Ferreira 《Small (Weinheim an der Bergstrasse, Germany)》2018,14(40)
Mesoporous silica materials have demonstrated a vast spectrum of applications, stimulating an intensive field of study due to their potential use as nanocarriers. Nonetheless, when produced at the nanoscale, their structural characterization is hindered due to the re‐arrangement of the pores. To address this issue, this work combines molecular dynamics simulations with electron microscopy computer simulations and experimental results to provide an insight into the structure of amorphous mesoporous silica nanoparticles. The amorphous silica model is prepared using a simple melt‐quench molecular dynamics method, while the reconstruction of the mesoporous nanoparticles is carried out using a methodology to avoid false symmetry in the final model. Simulated scanning transmission electron microscopy images are compared with experimental images, revealing the existence of structural domains, created by the misalignment of the pores to compensate the surface tension of these spherical nanoparticles. 相似文献
59.
Horst Kesselmeier Inga Tschiersch Klaus Henning Beate Stoffels Sebastian Kutscha 《AI & Society》1998,12(1-2):55-63
Today technology design can no longer be understood as a design process on a green site. Design and implementation of new technology are always dependent on existing technology and the way it is used by people. In this respect Software-Engineering has also changed to the characteristics of normal technology design taking into account existing computer systems. Experiences show that the conditions and needs of such Software-Reengineering projects are highly complex and differ in their special characteristics ranging from aspects of quality of existing system documentation to organizational structures of the computer departments concerned. The Task-Artifact Cycle presented here gives a suitable reengineering approach emphasizing both analysis and design in Software-Reengineering. 相似文献
60.
Sebastian Grottel Guido Reina Carsten Dachsbacher Thomas Ertl 《Computer Graphics Forum》2010,29(3):953-962
Molecular dynamics simulations are a principal tool for studying molecular systems. Such simulations are used to investigate molecular structure, dynamics, and thermodynamical properties, as well as a replacement for, or complement to, costly and dangerous experiments. With the increasing availability of computational power the resulting data sets are becoming increasingly larger, and benchmarks indicate that the interactive visualization on desktop computers poses a challenge when rendering substantially more than millions of glyphs. Trading visual quality for rendering performance is a common approach when interactivity has to be guaranteed. In this paper we address both problems and present a method for high‐quality visualization of massive molecular dynamics data sets. We employ several optimization strategies on different levels of granularity, such as data quantization, data caching in video memory, and a two‐level occlusion culling strategy: coarse culling via hardware occlusion queries and a vertex‐level culling using maximum depth mipmaps. To ensure optimal image quality we employ GPU raycasting and deferred shading with smooth normal vector generation. We demonstrate that our method allows us to interactively render data sets containing tens of millions of high‐quality glyphs. 相似文献