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101.
Wataru Kubo Kunihiko Itoh Shozo Miyazaki David Attwood 《Drug development and industrial pharmacy》2013,39(8):819-825
ABSTRACTThe aim of this study was to evaluate the potential of an in situ gelling pectin formulation as a vehicle for the oral sustained delivery of theophylline and cimetidine. In vitro studies demonstrated diffusion-controlled release of theophylline from 1, 1.5, and 2% w/v pectin gels. Release of this drug from 1.5% w/v pectin gels formed in situ in rabbit stomach was sustained over a period of 12 hours giving a theophylline bioavailability some seven fold higher than when administered from a commercial syrup. In contrast, interactions between cimetidine and pectin led to weak gelation of the pectin sols that prevented any meaningful determination of in vitro release characteristics. Similarly, in vivo release profiles from pectin formulations containing cimetidine were similar to that from a solution of this drug in buffer, indicative of weak gelation. Examination of the content of the rabbit stomach 5 hours after administration of 1.5% w/v pectin sols containing drug confirmed gel formation, but gels containing cimetidine were noticeably softer than those containing theophylline. 相似文献
102.
Fuminari Kaneko 《Electrochimica acta》2007,53(2):549-554
Tris(methoxy polyethylenglycol) borate ester (B-PEG) and aluminum tris(polyethylenglycoxide) (Al-PEG) were used as electrolyte solvent for lithium ion battery, and the electrochemical property of these electrolytes were investigated. These electrolytes, especially B-PEG, showed poor electrochemical stability, leading to insufficient discharge capacity and rapid degradation with cycling. These observations would be ascribed to the decomposition of electrolyte, causing formation of unstable passive layer on the surface of electrode in lithium ion battery at high voltage. However, significant improvement was observed by the addition of aluminum phosphate (AlPO4) powder into electrolyte solvent. AC impedance technique revealed that the increase of interfacial resistance of electrode/electrolyte during cycling was suppressed by adding AlPO4, and this suppression could enhance the cell capabilities. We infer that dissolved AlPO4 components formed electrochemically stable layer on the surface of electrode. 相似文献
103.
Yoshino M. Kaneko S. Taniguchi T. Miki N. Kumozaki K. Imai T. Yoshimoto N. Tsubokawa M. 《Lightwave Technology, Journal of》2008,26(8):962-970
In order to relax the limitation of the number of multiplexed signal lights caused by beat noise between signal lights, we investigate the applicability of a heterodyne detection technique to a spectral amplitude coding optical code division multiple access scheme. In this investigation, for the first time, we found analytically that the optical frequency chips that form parts of the signal and local lights require uniform phase differences even for envelope detection. We also confirm this requirement and our theoretical analysis experimentally. 相似文献
104.
Hiromi Odaka Masataka Yamada Ryohei Sakuma Cuie Ding Eiji Kaneko Satoru Yanabu 《Electrical Engineering in Japan》2007,161(1):17-25
A high‐speed vacuum circuit breaker (HSVCB) has been investigated. HSVCB makes high‐frequency current superimposed on a fault current so that the current is forced to be zero and is interrupted. Its interruption performance is considered to be dependent on the rate of change of the current (di/dt). As a fundamental research, we investigated the di/dt– dv/dt characteristics and the insulation recovery characteristic after interrupting the counter‐pulse current for various contact materials of AgWC, CuW, and CuCr. The results revealed that the case where the gap length is larger is better in a current interruption performance. Moreover, it was found that di/dt is not dependent on the insulation recovery characteristics, but the magnitude of interruption current is of great influence. © 2007 Wiley Periodicals, Inc. Electr Eng Jpn, 161(1): 17– 25, 2007; Published online in Wiley InterScience ( www.interscience.wiley.com ). DOI 10.1002/eej.20362 相似文献
105.
106.
Shigeo Yamabe Kazuo Kobayashi-Hattori Kentaro Kaneko Hiroshi Endo Toshichika Takita 《Food chemistry》2007,100(1):369-374
To clarify the effect of soybean varieties on isoflavone, a useful component for human health, in soybean products, we investigated changes in the isoflavone content and composition in rice-koji miso, after fermentation/aging for 6 or 12 months using varieties of soybeans (Tohoku-126, Tohoku-135, Tohoku-139, Suzuyutaka and Chinese soybeans), by high performance liquid chromatography. In soybeans, the total isoflavone content in Tohoku-126 was 444 mg/100 g, which was 1.2–2.0 times the content in the other soybean varieties. The malonyl glycosides and aglycones in soybeans accounted for more than 60% and only a few percent, respectively. As for rice-koji miso, the total isoflavone and aglycone contents were the highest in miso prepared from Tohoku-126. The ratios of glycosides to aglycones (80.1–92.6%) in miso were higher than those in the original soybeans. The time course of the isoflavone composition during the fermentation/aging process of rice-koji miso indicated that glycosides decreased from 86.4% to 44.9% after 6 months but aglycones increased from 9.6% to 53.3%. 相似文献
107.
A remarkable threshold current density reduction (from 3.5 kA/cm/sup 2/ to 1.6 kA/cm/sup 2/) of GaInP/AlInP visible light lasers grown by gas source molecular beam epitaxy (GS-MBE) was obtained by introducing 50 pairs of GaInP(7.1 AA)/AlInP(7.1 AA) short period superlattice confinement (SLC) layers. As a result, the room temperature continuous wave (CW) operation was obtained at 669 nm with a minimum threshold current of 50 mA and maximum light output of 10.5 mW.<> 相似文献
108.
Ludwik Blaz Makoto Sugamata Junichi Kaneko Jakub Sobota Grzegorz Wloch Wlodzimierz Bochniak Anna Kula 《Journal of Materials Processing Technology》2009,209(9):4329-4336
Experiments on mechanical consolidation of rapidly solidified (RS) powder of 6061 + 26 mass% Si alloy were performed using the oscillating-die extrusion method. The RS powder was wrapped in thin-wall 6061-alloy cup 35 mm in diameter and vacuum-compressed by means of 100 ton press. Bars 8 mm in diameter were extruded with cross-section reduction of λ = 19 without any preheating of the charge. Tubes with a diameter/wall thickness of 14 mm/1 mm and cross-section reduction of λ = 33 were also manufactured with success. TEM/STEM observations revealed a very fine structure of as-extruded material and bimodal distribution of quasi-spherical silicon particles. Statistical analysis revealed a silicon fine fraction of 0.1–0.7 μm and a coarse fraction 2.1–2.5 μm in diameter. Examination by means of TEM did not reveal any significant changes in the morphology of the silicon particles, even when a high extrusion ratio and the material annealing after deformation were used. Hot compression tests on as-extruded rods (λ = 19) and preliminary annealed samples were performed at a constant true strain rate of 5 × 10?3 s?1 within the temperature range of 293–823 K. High strength of the material and relatively high ductility of samples deformed by compression up to ?t ? 0.4 were observed. The maximum flow stress value for as-extruded material was reduced with deformation temperature from ~390 to ~3.5 MPa for 293 and 823 K, respectively. Annealing of the samples at 773 K/30 min was found to reduce the maximum flow stress by 30–40%. Tensile strengths of similar as-cast alloys and materials manufactured by means of other powder metallurgy methods were shown for the purpose of comparison. 相似文献
109.
Summary The peracetylated and free glucose-substituted poly(p-phenylene)s were synthesized by the coupling polymerization of a dibromobenzene monomer using Ni complex and the subsequent
deacetylation by hydrazine monohydrate. The polymerization was carried out using bis(1,5-cyclooctadiene)nickel(0) (Ni(COD)2) as a coupling agent with 2,2’-bipyridyl (bpy) and 1,5-cyclooctadiene (COD) in a mixed solvent of DMF and toluene. The structure
of the product was confirmed by 1H and 13C NMR measurements to be the poly(p-phenylene) having peracetylated glucose residues. The Mn values were estimated by GPC analysis with DMF as eluent to be 7300–9800. The fluorescence analysis of the polymer was carried
out in comparison with that of the dimeric model compound. The CD spectrum of the polymer indicated that the main-chain was
twisted and immobilized in one direction due to the chirality and bulkily of the peracetylated glucose residues. The deacetylation
using hydrazine monohydrate completely took place to give the free glucose-substituted poly(p-phenylene). 相似文献
110.
Proposes a vision-based active sensing system, termed vision-based active antenna. This is composed of a camera, a flexible beam whose force-deformation characteristic is known, and an actuator for rotating the beam. The camera observes the beam deformation, including the contact information, while the beam is in contact with an object. By solving a set of equations based on the information acquired through the camera, the sensor can detect the contact location, the contact force, and the stiffness of the object, even though the contact point is hidden by occlusion. For two particular versions, we show some experimental results to verify the basic idea 相似文献