Performance-based seismic design of steel frames using ant colony optimization

In this paper, a performance-based optimal seismic design of frame structures is presented using the ant colony optimization (ACO) method. This discrete metaheuristic algorithm leads to a significant improvement in consistency and computational efficiency compared to other evolutionary methods. A nonlinear analysis is utilized to arrive at the structural response at various seismic performance levels, employing a simple computer-based method for push-over analysis which accounts for first-order elastic and second-order geometric stiffness properties. Two examples are presented to illustrate the capabilities of ACO in designing lightweight frames, satisfying multiple performance levels of seismic design constraints for steel moment frame buildings, and a comparison is made with a standard genetic algorithm (GA) implementation to show the superiority of ACO for the discussed optimization problem.     

Hormone replacement therapy and risk of hip fracture: population based case-control study. The Swedish Hip Fracture Study Group

OBJECTIVE: To determine the relative risk of hip fracture associated with postmenopausal hormone replacement therapy including the effect of duration and recency of treatment, the addition of progestins, route of administration, and dose. DESIGN: Population based case-control study. Setting: Six counties in Sweden. SUBJECTS: 1327 women aged 50-81 years with hip fracture and 3262 randomly selected controls. MAIN OUTCOME MEASURE: Use of hormone replacement therapy. RESULTS: Compared with women who had never used hormone replacement therapy, current users had an odds ratio of 0.35 (95 % confidence interval 0.24 to 0.53) for hip fracture and former users had an odds ratio of 0.76 (0.57 to 1.01). For every year of therapy, the overall risk decreased by 6% (3% to 9%): 4% (1% to 8%) for regimens without progestin and 11% (6% to 16%) for those with progestin. Last use between one and five years previously, with a duration of use more than five years, was associated with an odds ratio of 0.27 (0.08 to 0.94). After five years without hormone replacement therapy the protective effect was substantially diminished (-7% to 48%). With current use, an initiation of therapy nine or more years after the menopause gave equally strong reduction in risk for hip fracture as an earlier start. Oestrogen treatment with skin patches gave similar risk estimates as oral regimens. CONCLUSIONS: Recent use of hormone replacement therapy is required for optimum fracture protection, but therapy can be started several years after the menopause. The protective effect increases with duration of use, and an oestrogen-sparing effect is achieved when progestins are included in the regimen.     

Endometrial glandular proliferation and estrogen receptor content during the normal menstrual cycle

The 5' untranslated region of an RNA molecule is thought to play an important role in the regulation of translation. Following a recent report that a single nucleotide is sufficient to act in this role in the unicellular organism Giardia, we show that this is also the case for a mammalian in vitro system. These results also demonstrate that an RNA can initiate translation from a start codon where an ideal translational consensus sequence is impossible.     

On the Influence of Crosslinker on Template Complexation in Molecularly Imprinted Polymers: A Computational Study of Prepolymerization Mixture Events with Correlations to Template-Polymer Recognition Behavior and NMR Spectroscopic Studies

Aspects of the molecular-level basis for the function of ethylene glycol dimethacrylate and trimethylolproprane trimethacrylate crosslinked methacrylic acid copolymers molecularly imprinted with (S)-propranolol have been studied using a series of all-component and all-atom molecular dynamics studies of the corresponding prepolymerization systems. The crosslinking agents were observed to contribute to template complexation, and the results were contrasted with previously reported template-recognition behavior of the corresponding polymers. Differences in the extent to which the two crosslinkers interacted with the functional monomer were identified, and correlations were made to polymer-ligand recognition behavior and the results of nuclear magnetic resonance spectroscopic studies studies. This study demonstrates the importance of considering the functional monomer–crosslinker interaction when designing molecularly imprinted polymers, and highlights the often neglected general contribution of crosslinker to determining the nature of molecularly imprinted polymer-template selectivity.     

Transfer of Ultrafine Particles and Air in Multi-storey Buildings

An emerging issue in Denmark is passive smoking in residential buildings where non-smokers are exposed to smoke from their neighbours. There are various ways that smoke is transferred from one flat to another. The air transfer rate between two flats in a multi-storey building depends on its construction, tightness and age. This paper presents results of a study on the transfer of ultrafine particles and tracer gas in an older multi-storey building in Copenhagen. The aim of the study was to quantify the transfer ofultrafine particles and gases from one flat to another fiat before and after sealing the floor. A new floor-sealing method was applied to seal the floor between the two flats. The sealing method was developed by a firm specialising in sealing. Indoor ultrafine particle concentrations and tracer gas were measured continuously in the two fiats during the measuring periods. In the unoccupied fiat, the gas source was N20 and the particle source was burning cigarettes. Reduction of the concentration of ultrafine particles and tracer gas by sealing the floor with polyethylene and joint filler made of bitumen was studied. It was evaluated how the sealing performed with regard to decreasing the amount of ultrafine particles and a tracer gas transferred between two fiats separated by a floor. When the floor between the flats was not sealed, the results showed that about 4% of the ultraflne particles and 14% of the tracer gas were transferred. After sealing, the amount transferred was reduced to 1.6% and 5%, respectively.     

Combined analytical/FEA-based coupled aero structure simulation of a wind turbine with bend–twist adaptive blades

The simulation of wind turbines with bend–twist adaptive blades is a coupled aero-structure (CAS) procedure. The blade twist due to elastic coupling is a required parameter for wind turbine performance evaluation and can be predicted through a finite element (FE) structural analyser. FEA-based codes are far too slow to be useful in the aerodynamic design/optimisation of a blade. This paper presents a combined analytical/FEA-based method for CAS simulation of wind turbines utilising bend–twist adaptive blades. This method of simulation employs the induced twist distribution and the flap bending at the hub of the blade predicted through a FEA-based CAS simulation at a reference wind turbine run condition to determine the wind turbine performance at other wind turbine run conditions. This reduces the computational time significantly and makes the aerodynamic design/optimisation of bend–twist adaptive blades practical. Comparison of the results of a case study which applies both combined analytical/FEA-based and FEA-based CAS simulation shows that when using the combined method the required computational time for generating a power curve reduces to less than 5%, while the relative difference between the predicted powers by two methods is only about 1%.     

Traffic differentiation support in vehicular delay-tolerant networks

Vehicular Delay-Tolerant Networking (VDTN) is a Delay-Tolerant Network (DTN) based architecture concept for transit networks, where vehicles movement and their bundle relaying service is opportunistically exploited to enable non-real time applications, under environments prone to connectivity disruptions, network partitions and potentially long delays. In VDTNs, network resources may be limited, for instance due to physical constraints of the network nodes. In order to be able to prioritize applications traffic according to its requirements in such constrained scenarios, traffic differentiation mechanisms must be introduced at the VDTN architecture. This work considers a priority classes of service (CoS) model and investigates how different buffer management strategies can be combined with drop and scheduling policies, to provide strict priority based services, or to provide custom allocation of network resources. The efficiency and tradeoffs of these proposals is evaluated through extensive simulation.     

Genetic-based random key generator (GRKG): a new method for generating more-random keys for one-time pad cryptosystem

In this paper, a new algorithm for generating more-randomized keys for symmetrical cipher one-time pad (OTP) according to the linear congruential (LCG) method based on the idea of genetic algorithm is proposed. The method, genetic-based random key generator, is proposed for generating keys for the OTP method with a high degree of key randomness; this adds more strength to the OTP method against breaking this cryptosystem. This algorithm is composed of two parts. Initially, the first population is being generated by LCG method, and then, genetic operators for generating the next populations are being used. Generating random keys with the presented method requires seven-parameter key that increases the security of communication between the transceivers.