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Drug Delivery: Drug‐Loaded Multifunctional Nanoparticles Targeted to the Endocardial Layer of the Injured Heart Modulate Hypertrophic Signaling (Small 33/2017) 下载免费PDF全文
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Marika SUOMALAINEN Sini SUOMALAINEN Virpi PURO Vuokko KYTONIEMI Aria LAMBERG 《生命科学仪器》2010,8(6):27-30
从复杂生物基质中快速、高效地分离核酸是在获取各种实验的最佳起始原料的重要一步。磁性粒子为基础的操作流程提供了一个快速简单的解决方案,它特别适合用于自动化,在获得纯净和完整的DNA或RNA时以最少的动手时间获得良好的重现性结果。因此,必须优化基于磁珠的纯化流程来达到最高质量与数量的核酸提取。本文介绍了一个自动化、高速、以磁性粒子为基础的纯化系统来实现理想的DNA纯化方案,并考察了不同搅拌速度组合,以及在洗脱步骤的加热效应对DNA纯化数量和质量的影响。 相似文献
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【摘要】 精确的钇-90(90Y)微球剂量对治疗肝脏恶性肿瘤至关重要,这与临床疗效和不良反应密切相关。剂量的计算主要基于不同的90Y载体:玻璃微球(TheraSpheres)或树脂微球(SIR- Spheres)。玻璃微球的剂量是以肝脏预期的辐射剂量和微球能够均匀分布于整个肝脏的假设为基础计算的,而树脂微球的剂量是以微球非均匀分布于整个肝脏的假设为基础计算的,这种非均匀分布的程度取决于正常肝脏被肿瘤组织取代的程度。许多其他因素也可能会潜在影响90Y微球的治疗剂量。本综述将介绍90Y微球剂量的计算方法,以及为了获得最大疗效并尽量避免不良反应发生而需要考虑的各种因素。
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The discharge of sewage effluent from ports in a long diffuser pipe on the ocean bottom produces a flow pattern that may be idealized as a buoyant jet from a line source. To minimize the impact of emission of pollutants, the dispersion of wastewater should be predictable, and the prediction of the maximum height of rise is important in determining whether or not the jet will remain submerged. A buoyancy-extended K-ε model of turbulence has been developed for calculating the dynamical and thermal fields in forced plane plumes vertically discharged into a stably stratified environment. The predicted maximum height of rise for the linearly stratified quiescent ambient case is compared with available experimental data. An idealized two-layer situation is then considered in such a way as to simulate a thermocline in the upper part of the ocean. Numerical results are presented for a uniform horizontal cross-stream situation. 相似文献
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The water absorption of sapwood and heartwood of Scots pine and Norway spruce heat-treated at 170 °C, 190 °C, 210 °C and 230 °C 总被引:2,自引:0,他引:2
Sini Metsä-Kortelainen Toni Antikainen Pertti Viitaniemi 《Holz als Roh- und Werkstoff》2006,64(3):192-197
Heat-treatment changes the chemical and physical properties of wood. Wood polymers are degraded, dimensional stability is enhanced, equilibrium moisture content is lowered, colour darkens and biological durability is increased. The properties of heat-treated wood have been researched considerably, but the differences between sapwood and heartwood have not been reported separately. In this research, water absorption differences between sapwood and heartwood of Scots pine and Norway spruce heat-treated at temperatures 170 °C, 190 °C, 210 °C and 230 °C were investigated. The results were compared to industrially kiln-dried reference samples. Water absorption was determined with a floating test based on the EN 927-5 standard. The heartwood of both wood species absorbed less water than sapwood. Heat-treatment evidently decreased the water absorption of spruce and pine heartwood. The higher the heat-treating temperature, the lower the amount of absorbed moisture. However, a very interesting exception was pine sapwood, whose water absorption actually increased with heat-treatment after the three lowest heat-treatment temperatures compared to the reference material. Water absorption did not decrease until the heat-treatment temperature was 230 °C. 相似文献