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51.
    
In the present study, propranolol loaded‐calcium alginate beads were prepared from concentrated solutions of sodium alginate, using combined method of electrospray and ionotropic gelation. The objectives of the study were to increase the propranolol‐HCl loading and to decrease its initial burst release. However, the effects of voltage, nozzle diameter, flow rate, and concentration of sodium alginate on size of the beads and drug entrapment efficiency (DEE) were also investigated. The matrix of alginate beads was reinforced with dextran sulfate and/or coated with chitosan. The mean particle size of the beads, their swelling behavior, and drug entrapment efficiency were characterized. Furthermore, the drug release profiles from the prepared beads in simulated gastric fluid and intestinal fluid were evaluated and compared. Among the parameters that affected the electrospray of alginate, voltage had a pronounced effect on the size of beads. The size of beads was reduced to a minimum value on increasing the voltage. Furthermore, increasing the flow rate, alginate concentration, and nozzle diameter and decreasing the voltage led to improvement in DEE. Enhancing the alginate concentration as well as coating with chitosan and reinforcing with dextran sulfate led to increase of the encapsulation efficiency and therefore decrease of the drug release rate in both pHs. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015 , 132, 41334.  相似文献   
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Three models were developed to estimate the potential of the selected bacteria Petrotoga sp., a thermophilic anaerobic oil‐degrading microorganism. Fourteen data sets of these bacteria were simulated by a multilayer feed‐forward neural network and an adaptive neuro‐fuzzy interference system. Twelve data sets served for training and two for testing these models. A simplified numerical model was performed assuming two phases in the growth process of oil‐degrading microorganisms, the logarithmic growth phase and the death phase. Comparison between these models in predicting bacterial cell concentration for different data sets indicates little difference between the overall average relative errors of the three methods and that all can be applied for prediction. Effects of salinity concentration, amount of yeast extract, and temperature on bacterial cell concentration were simulated by numerical and neural network models.  相似文献   
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In this research, the effect of various surface treatments including laser processing, grit blasting and anodizing on chemical structure, surface topography, and bioactivity of Ti-6Al-4V was investigated. Six groups of samples were prepared by a combination of two alternative laser processes, grit blasting and anodizing. Selected samples were first evaluated using microanalysis techniques and contact roughness testing and were then exposed to in vitro environment. Scanning electron microscopy was used to characterize the corresponding final surface morphologies. Weight measurement and atomic absorption tests were employed for determination of bioactivity limits of different surface conditions. Based on the data obtained in this study, low-energy laser processing generally yields a better biological response. The maximum bioactivity was attained in those samples exposed to a three step treatment including low-energy laser treatment followed by grit blasting and anodizing.  相似文献   
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Previous laboratory studies have reported that moderate caffeine consumers develop a liking for the flavour of a novel caffeinated drink. The present study tested whether results from laboratory studies are applicable to real-life situations. Forty moderate caffeine consumers were randomly allocated to four conditions (n = 10). Three of these conditions involved consumption of two novel flavoured fruit drinks, one caffeinated (100 mg) and one without caffeine, at different times of the participants’ daily routine (breakfast, anytime, night). Participants in the final (control) condition evaluated the drinks on the three test days only. Those participants who received the drinks at breakfast showed a significant increase in liking for the flavour of the caffeinated drink, whereas those who consumed the drinks at night showed a significant decrease in liking for the same flavour. Results imply that the post-ingestive effect of caffeine may depend on the time and condition during which the caffeinated flavour is consumed.  相似文献   
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Alginate and chitosan nanoparticles were prepared using a new reverse micelle system, composed of cetyltrimethylammonium bromide (CTAB) as a surfactant, isooctane as a solvent, and 1-hexananol as a co-solvent. The obtained nanoparticles were characterized by FTIR, DLS and TEM techniques. The main objective of this study was to investigate the effects of polymer concentration, water content, and volumetric ratio of co-solvent to solvent on the physical and morphological properties of the prepared nanoparticles. To evaluate the results, the design of experimental was initially carried out and then the obtained data were statistically analyzed using the Qualitek-4? software. Results revealed that the size of the prepared alginate and chitosan nanoparticles varied in the range 220?C490 and 210?C1,050?nm, respectively. Furthermore, increasing either alginate or chitosan concentration increased the size of their nanoparticles. The results also showed that the size of nanoparticles was decreased with increasing the volumetric ratio of co-solvent/solvent. Finally, the size of alginate nanoparticles was increased by increasing the water content while it decreased the size of chitosan nanoparticles. Considering the statistical analysis of experiments, the polymer concentration is the major parameter affecting nanoparticles?? size. In contrast, water content has the smallest effect on the size of nanoparticles. However, the difference between the particle sizes of chitosan and alginate nanoparticles cab be attributed to the electrostatic repulsion between chitosan and CTAB.  相似文献   
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In this paper, the underwater implementation of the incremental adaptive networks is proposed based on the visible light communication technology. The underwater distance between transmitter and receiver nodes and the salinity and temperature levels of the considered water determines the stochastical properties of the underwater link that is modeled with the Log-normal distribution. The incremental network performance can be expressed with the excess mean square error and mean square deviation values and we used them in this paper for our theoretical analysis. Our findings showed that the distances between the nodes must not be more than 10 m or the incremental network will diverge from its estimation goal. The network performance is analyzed through multiple link distances and the results are presented with several simulations. The simulation results are devised in order to elaborate the effects of the underwater turbulent links on the performances of estimating adaptive network. Also, the impacts of different salinity and temperature levels are analyzed theoretically and the results are compared with the simulation results.

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An Adaptive and Cost-Based Intrusion Response System (ACBIRS) is presented in this paper. The designed system analyzes alerts from the Intrusion Detection System (IDS) and evaluates the attack cost, based on the probable damage of attacks on the protected system. Later on, a response is deployed to thwart the attack and prevent the attacker from reaching his/her goals. The proposed response selection approach is a cost-based method that considers attack features, including type of the attack, severity of the attack, value of targeted host/hosts services, and their data to prioritize alerts. Alerts will be responded with respect to their priorities. The selected responses are based on a measure called Response Merit (RM). The balance between attack damage cost, response cost together with the effectiveness of the response to countermeasure previous attacks determine the RM. In contrast to other Intrusion Response Systems (IRS), ACBIRS not only consists of the attack and response measures but also includes response feedback supervision that is proposed in this paper for the first time. ACBIRS allows responses to be adaptive in changing environments through success and failure assessment of previously deployed responses. Experiments show that ACBIRS can successfully prevent 92% of intrusions with only 3% disruption on benign traffic.  相似文献   
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