用于列ADC电路的斜坡发生器设计

设计了一种用于CMOS图像传感器列级模数转换器(Analog-to-Digital Converter,ADC)电路的10位斜坡发生器.详细介绍了电路的整体结构、工作模式以及仿真结果.在电路中采用了两级转换的方式,并设计了电阻阵列式多路斜坡发生器.在Cadence设计平台下,对模拟电路进行了设计、仿真和版图设计.采用0.5μm双层多晶三层金属(Double Poly Triple Metal,DPTM) CMOS工艺对电路进行了制作.仿真结果表明,该设计基本满足相关要求.     

对地观测星载激光测高系统高程误差分析

星载激光测高系统通过接收卫星平台激光器发出的激光脉冲经地表反射的微弱回波,计算卫星与地表的距离;结合卫星轨道和姿态数据,生成激光脚点精确地理位置和高程结果.其高程误差主要受器件、环境和目标参数影响,目前还没有完整描述对地观测星载激光测高系统平面和高程误差的数学模型.简化并完善了针对固体地表的激光测距误差模型,建立了完整的激光脚点平面和高程误差模型.利用高程精度和空间分辨率更高的机载Lidar数据评估了星载激光测高系统GLAS实测数据的高程偏差,评估结果符合所建误差模型.在较平坦的冰盖表面,GLAS系统高程精度可以达到设计值约15 cm.研究内容对测高系统高程误差评估和系统参数设计具有参考意义.     

基于Proteus的气压报警系统设计

利用Proteus设计了一种数字气压报警系统。通过MPX4115气压传感器获得与大气压相对应的模拟电压值,经过V/F转换器将模拟电信号转换为数字脉冲信号输入到单片机,单片机接收脉冲信号,经计算处理得出实际的气压值,最后通过数码管显示电路显示出来,并在Proteus上成功完成了仿真调试。结果表明本系统具有携带方便,操作简单,精确度高,适合远距离传送,并可根据具体情况设置警戒值进行智能监测报警,可实现不同环境下的分布-集中监控的特点。     

铝合金激光-MIG复合焊接头性能研究

探讨了激光与电弧相互作用后,焊缝中心上部和下部晶粒大小不同的原因,在此基础上研究了焊接速度的改变对6009铝合金接头的微观组织、拉伸性能、显微硬度的影响。结果表明：6009铝合金激光-MIG焊焊接接头的抗拉强度和延伸率随着焊接速度的增加而增加,拉伸试样的断裂位置由焊缝区转移到热影响区,断口呈现均匀分布的韧窝形貌,断裂机制为微孔聚集形断裂;焊缝中心上部晶粒小于焊缝中心下部,而且尺寸分布均匀。焊缝中心上部的显微硬度则高于焊缝下部。接头热影响区存在软化区,宽度为4～6 mm。     

基于相关法的分布式全相参雷达相干参数估计及相参性能

针对一般结构的分布式全相参雷达,研究了基于相关法的时延差和相位差估计性能以及输出信噪比增益(oSNRg)。首先分别建立多输入多输出(MIMO)模式和全相参(FC)模式下的信号模型。然后重点分析估计相位差时的相位模糊问题,并提出一种有效的解模糊方法。数值实验结果表明：当输入信噪比足够高时,相关法能够获得稳健的相干参数估计,且oSNRg接近理想值。     

端面反射率对单端反射半导体光放大器的影响

本文考虑了光子密度、增益谱色散、放大自发辐射噪声(ASE)、端面反射率和载流子浓度对折射率的影响,并采用细化分段法及四阶龙格-库塔法求解速率方程及光场传输方程,分析了不同端面反射率时单端反射半导体光放大器(RSOA)的动态特性。结果表明端面反射率的适当增加,可以使增益得到提高,增益恢复时间减少, ASE输出功率增加,消光比下降。理论分析为优化RSOA的动态特性具有一定的指导意义。     

Superhydrophobic “Pump”: Continuous and Spontaneous Antigravity Water Delivery

Antigravity transportation of water, which is often observed in nature, is becoming a vital demand for advanced devices and new technology. Many studies have been devoted to the motion of a single droplet on a horizontal or inclined substrate under specific assistance. However, the self‐propelled water motion, especially continuous antigravity water delivery, still remains a considerable challenge. Here, a novel self‐ascending phenomenon driven only by the surface energy release of water droplets is found, and a superhydrophobic mesh to pump water up to a height of centimeter scale is designed. An integrated antigravity transportation system is also demonstrated to continuously and spontaneously pump water droplets without additional driving forces. The present novel finding and integrated devices should serve as a source of inspiration for the design of advanced materials and for the development of new technology with exciting applications in microfluidics, microdetectors, and intelligent systems.     

Optimizing the Size of Micellar Nanoparticles for Efficient siRNA Delivery

Delivery of small interfering RNA (siRNA) by nanocarriers has shown promising therapeutic potential in cancer therapy. However, poor understanding of the correlation between the physicochemical properties of nanocarriers and their interactions with biological systems has significantly hindered its anticancer efficacy. Herein, in order to identify the optimal size of nanocarriers for siRNA delivery, different sized cationic micellar nanoparticles (MNPs) (40, 90, 130, and 180 nm) are developed that exhibit similar siRNA binding efficacies, shapes, surface charges, and surface chemistries (PEGylation) to ensure size is the only variable. Size‐dependent biological effects are carefully and comprehensively evaluated through both in vitro and in vivo experiments. Among these nanocarriers, the 90 nm MNPs show the optimal balance of prolonged circulation and cellular uptake by tumor cells, which result in the highest retention in tumor cells. In contrast, larger MNPs are rapidly cleared from the circulation and smaller MNPs are inefficiently taken up by tumor cells. Accordingly, 90 nm MNPs carrying polo‐like kinase 1 (Plk1)‐specific siRNA (siPlk1) show superior antitumor efficacy, indicating that 90 nm could either be the optimal size for systemic delivery of siRNA or close to it. Our findings provide valuable information for rationally designing nanocarriers for siRNA‐based cancer therapy in the future.     

Self‐Assembling Prodrugs by Precise Programming of Molecular Structures that Contribute Distinct Stability,Pharmacokinetics, and Antitumor Efficacy

The availability of precisely modulated chemical modifications dramatically affects the physicochemical properties of pristine drugs and should facilitate the amphiphilic self‐assembly of prodrugs into supramolecular nanoprodrugs (SNPs). However, rationally designing such prodrugs to achieve favorable clinical outcomes still remains a challenge. Here, a library of prodrugs through site‐specific attachment of a variety of lipophilic moieties to the antitumor agent SN‐38 (7‐ethyl‐10‐hydroxycamptothecin) is constructed. Taking advantage of the role of hydroxyl groups as solvophilic moieties, these prodrugs exhibit self‐assembly in aqueous environments, allowing for the identification of five prodrugs capable of self‐assembling into SNPs at high drug concentrations. Importantly, in vivo studies demonstrate that the antitumor activity of the SNPs correlates well with their stability and long‐term circulation. In addition, the modular feature of this SNP design strategy offers the opportunity to readily incorporate additional valuable functionalities (e.g., tumor‐specific targeting ligands) to the particle surface, which is further exploited to improve antitumor efficacy in mouse xenograft models. Thus, this structure‐based reconstruction of SN‐38 molecules significantly improves the potency of SNPs for clinical use. These results also provide novel mechanistic insights into the rational design of prodrugs.     

基于Internet的高校体育教学信息网页的设计与实现

通过分析高校体育网页建设的可行性及现状,提出了基于Internet的体育教学信息网页的总体设计,简要介绍了系统各功能模块及数据库设计,讨论了采用ASP、JavaScript技术及ACCESS开发系统的数据库访问技术和动态网页制作技术,并给出了部分实现代码.