Obstacles for cognitive analogy in analysis and synthesis in microsystems development

In most cases, product development is not inventing a product completely new and from scratch, it typically either adds a few newly developed sub-functions to mainly known sub-functions, or it generates invention based on new combinations of already existing and slightly modified sub-functions. This synthesis is ideally based on a preceding and comprehensive system analysis that is necessary to define promising directions for advancement in further product development. In analysis as well as in synthesis the design engineer needs creativity—either to be able to recognize which functions are realized in a given system that is subject to analysis or to be able to think up new ways how a desired function could be realized in a system. The main cognitive mechanism for creativity is analogy and this mechanism in turn is based on schemas and mental models. In microsystems development, micro specific obstacles accrue when using analogies. In this work, the authors derive the nature and source of these obstacles and their implications on microsystems development. To overcome these obstacles, a functions catalogue is proposed. This catalogue can directly be used to add an external source for analogies during system synthesis. By transferring a method called geometrical similarity search to microsystems technology and combining it with the functions catalogue, system analysis can be supported as well.     

Influence of Whey Protein Addition and Feed Moisture Content on Chosen Physicochemical Properties of Directly Expanded Corn Extrudates

Production of extrudates from cereals is an often-used technological process in today’s world food industry. Extrudates from corn flour produced using the twin-screw extrusion process and enriched with whey protein concentrate represent high-quality source of proteins and fats. Whey protein concentrate (WPC) as a valuable source of proteins and minerals is one of the highest-quality components for possible extrudate enrichment. In this paper, the influence of various WPC addition and some extrusion process parameters such as feed moisture content ( Q_{textHtext2 textO} Q_{{{text{H}}_{text{2}} {text{O}}}} ) on physicochemical properties of directly expanded corn flour extrudates manufactured in twin-screw co-rotating extruder was investigated. Whey protein concentrate was added in the following ratios 7.5%, 15% and 22.5% and water in 10.08, 12.18 and 14.28 L/h. Final composition of products is determined with measuring of protein, fat and water shares, water absorption index (WAI) and water solubility index (WSI). With added WPC and with increase of water volume flow, there was a significant rise in total protein, fat and water content in final products, as well as lowering of WSI and rising of WAI indexes. The statistical analysis of the obtained data shows that the lowest WSI and the highest WAI had samples with the largest share of WPC (22.5%) and water volume flow of 14.28 L/h. Colour is measured for each sample, and results were represented with hue angle (H), chroma (C) and lightness (L) values. Process parameters, WPC and Q_{textHtext2 textO} Q_{{{text{H}}_{text{2}} {text{O}}}} influence the increase of saturation of C and lightness of L colour value, while H value stays unchanged. Mean value of H was 90.14 ± 1.06, which corresponds to dominance of yellow colour of samples.     

Minimum cost flows with minimum quantities

We consider a variant of the well-known minimum cost flow problem where the flow on each arc in the network is restricted to be either zero or above a given lower bound. The problem was recently shown to be weakly NP-complete even on series-parallel graphs. We start by showing that the problem is strongly NP-complete and cannot be approximated in polynomial time (unless P=NP) up to any polynomially computable function even when the graph is bipartite and the given instance is guaranteed to admit a feasible solution. Moreover, we present a pseudo-polynomial-time exact algorithm and a fully polynomial-time approximation scheme (FPTAS) for the problem on series-parallel graphs.     

Experimental Investigation of the Flow in a Continuous-Casting Mold under the Influence of a Transverse,Direct Current Magnetic Field

This article describes laboratory experiments aimed at investigations of flow structures and related transport processes in the continuous-casting mold under the influence of an external direct current (DC) magnetic field. The main value of cold metal laboratory experiments consists in the capabilities to obtain quantitative flow measurements with a reasonable spatial and temporal resolution. The experimental results presented here were obtained using a physical model operating with the room-temperature alloy GaInSn. According to the concept of the electromagnetic brake, the impact of a DC magnetic field on the outlet flow from the submerged entry nozzle (SEN) has been studied up to Hartmann numbers of approximately 400. The effect of the magnetic field on the flow structure turned out to be complex. The flow measurements do not manifest a general braking effect, which would be expected as an overall damping of the flow velocity and the related fluctuations all over the mold volume. Variations of the wall conductivity showed a striking impact on the resulting flow structures. The experiments provide a substantial database for the validation of respective numerical simulations.     

Sensitivity analysis of a finite element model for the simulation of stainless steel tube extrusion

In this work, a sensitivity analysis has been performed on a finite element model of glass-lubricated extrusion of stainless steel tubes. Fifteen model parameters, including ram speed, billet and tool temperatures, friction coefficients and heat transfer coefficients, were considered. The aim of the study was to determine the parameters that are most important for the response of the extrusion force. The relationship between the model parameters and the responses was analyzed by a calculation of two different regression models: one linear polynomial model and one model that includes interaction terms. Additional simulations were then carried out to validate the regression models. The results show that the initial billet temperature is the factor that has the strongest impact on the extrusion force within the parameter ranges studied in this work. The goodness of prediction and goodness of fit are very good for both regression models.     

Borcalein: a Carborane-Based Analogue of Baicalein with 12-Lipoxygenase-Independent Toxicity

12-Lipoxygenase is crucial for tumour angiogenesis. 5,6,7-Trihydroxy-2-phenyl-4H-1-benzopyran-4-one (baicalein) is a suitable inhibitor for this enzyme but is rapidly metabolised in vivo. Thus, an improvement of the metabolic stability is necessary to enhance the therapeutic efficiency. An emerging approach to enhance metabolic stability of carbon-based pharmaceuticals is the use of metabolically stable, non-toxic boron clusters, such as dicarba-closo-dodecaborane(12)s (carboranes) as phenyl mimetics. Therefore, the unsubstituted phenyl ring of baicalein was replaced by meta-carborane, resulting in borcalein, the carborane analogue of baicalein. This substitution resulted in a decreased inhibitory activity toward 12-lipoxygenase, but led to increased toxicity in melanoma (A375, B16, B16F10) and colon cancer cell lines (SW480, HCT116, CT26CL25) with decreased tumour selectivity in comparison to baicalein. Surprisingly, borcalein displays a different mechanism of cytotoxicity with increased intracellular production of reactive oxygen species (ROS), reactive nitrogen species (RNS) and nitric oxide (NO).     

Cuticular Extracts from Acromis sparsa (Coleoptera: Cassidinae) Mediate Arrestment Behavior of the Commensal Canestriniid Mite Grandiella rugosita

Astigmatid mites in the family Canestriniidae are often closely associated with tortoise leaf beetles (Chrysomelidae: Cassidinae). For example, the survival of the commensal canestriniid mite Grandiella rugosita depends on dispersal to the cassidine beetle Acromis sparsa. Here, we tested whether the beetle cuticle provides chemical cues for host recognition for G. rugosita. In two-choice assays with cuticular extracts from A. sparsa and the co-occurring, non-host cassidine Chelymorpha alternans offered simultaneously, mites clearly preferred the area treated with extract from their host. In no-choice assays, G. rugosita spent three times longer and moved three times slower on host cuticular extracts compared to non-host extracts and the solvent control. Analyses of the chemical composition of cuticular extracts from males and females of A. sparsa and C. alternans revealed complex mixtures of mainly methyl branched hydrocarbons, which clearly separated both species in a principal component analysis. We found no qualitative difference between males and females of either species, but in C. alternans quantitative differences between males and females were detected. Our results demonstrate that G. rugosita is able to discriminate between cuticular extracts from its host A. sparsa and the non-host C. alternans. The components eliciting the observed arrestment behavior remain to be determined.