Ray analysis of a class of hybrid cylindrical aircraft wings

A new approach to the modelling of aircraft wings, based on the combination of hybrid quadric (parabolic and circular) cylinders, has been presented for electromagnetic applications. Closed-form expressions have been obtained for ray parameters required in the high-frequency mutual coupling computation of antenna pairs located arbitrarily on an aircraft wing     

Acetophenone-Based 3,4-Dihydropyrimidine-2(1H)-Thione as Potential Inhibitor of Tyrosinase and Ribonucleotide Reductase: Facile Synthesis,Crystal Structure,In-Vitro and In-Silico Investigations

The acetophenone-based 3,4-dihydropyrimidine-2(1H)-thione was synthesized by the reaction of 4-methylpent-3-en-2-one (1), 4-acetyl aniline (2) and potassium thiocyanate. The spectroscopic analysis including: FTIR, ¹H-NMR, and single crystal analysis proved the structure of synthesized compound (4), with the six-membered nonplanar ring in envelope conformation. In crystal structure, the intermolecular N–H ⋯ S and C–H ⋯ O hydrogen bonds link the molecule in a two-dimensional manner which is parallel to (010) the plane enclosing R₂² (8) and R₂² (10) ring motifs. After that, the Hirshfeld surfaces and their related two-dimensional fingerprint plots were used for thorough investigation of intermolecular interactions. According to Hirshfeld surface analysis, the most substantial contributions to the crystal packing are from H ⋯ H (59.5%), H ⋯ S/S ⋯ H (16.1%), and H ⋯ C/C ⋯ H (13.1%) interactions. The electronic properties and stability of the compound were investigated through density functional theory (DFT) studies using B3LYP functional and 6-31G* as a basis set. The compound 4 displayed the high chemical reactivity with chemical softness of 2.48. In comparison to the already reported known tyrosinase inhibitor, the newly synthesized derivatives exhibited almost seven-fold better inhibition of tyrosinase (IC₅₀ = 1.97 μM), which was further supported by molecular docking studies. The compound 4 inside the active pocket of ribonucleotide reductase (RNR) exhibited a binding energy of −19.68 kJ/mol, and with mammalian deoxy ribonucleic acid (DNA) it acts as an effective DNA groove binder with a binding energy of −21.32 kJ/mol. The results suggested further exploration of this compound at molecular level to synthesize more potential leads for the treatment of cancer.     

miRNAs in Regulation of Tumor Microenvironment,Chemotherapy Resistance,Immunotherapy Modulation and miRNA Therapeutics in Cancer

miRNAs are 20–22 long nucleotide non-coding ribonucleic acid molecules critical to the modulation of molecular pathways. Immune evasion and the establishment of a suitable tumor microenvironment are two major contributors that support tumor invasion and metastasis. Tumorigenic miRNAs support these two hallmarks by desensitizing important tumor-sensitive regulatory cells such as dendritic cells, M1 macrophages, and T helper cells towards tumors while supporting infiltration and proliferation of immune cells like Treg cells, tumor-associated M2 macrophages that promote self-tolerance and chronic inflammation. miRNAs have a significant role in enhancing the efficacies of immunotherapy treatments like checkpoint blockade therapy, adoptive T cell therapy, and oncolytic virotherapy in cancer. A clear understanding of the role of miRNA can help scientists to formulate better-targeted treatment modalities. miRNA therapeutics have emerged as diverse class of nucleic acid-based molecules that can suppress oncogenic miRNAs and promote the expression of tumor suppressor miRNAs.     

N-Acetyl-d-Glucosamine Kinase Interacts with NudC and Lis1 in Dynein Motor Complex and Promotes Cell Migration

Recently, we showed that N-acetylglucosamine kinase (NAGK), an enzyme of amino sugar metabolism, interacts with dynein light chain roadblock type 1 (DYNLRB1) and promotes the functions of dynein motor. Here, we report that NAGK interacts with nuclear distribution protein C (NudC) and lissencephaly 1 (Lis1) in the dynein complex. Yeast two-hybrid assays, pull-down assays, immunocytochemistry, and proximity ligation assays revealed NAGK–NudC–Lis1–dynein complexes around nuclei, at the leading poles of migrating HEK293T cells, and at the tips of migratory processes of cultured rat neuroblast cells. The exogenous expression of red fluorescent protein (RFP)-tagged NAGK accelerated HEK293T cell migration during in vitro wound-healing assays and of neurons during in vitro neurosphere migration and in utero electroporation assays, whereas NAGK knockdown by short hairpin RNA (shRNA) delayed migration. Finally, a small NAGK peptide derived from the NudC interacting domain in in silico molecular docking analysis retarded the migrations of HEK293T and SH-SY5Y cells. These data indicate a functional interaction between NAGK and dynein–NudC–Lis1 complex at the nuclear envelope is required for the regulation of cell migration.     

Novel synthesis and antimicrobial studies of nanoscale titania particles

In the present investigation, a novel strategy of continuous microwave assisted flow synthesis (CMFS) has been adopted in comparison to traditional synthesis procedures (sol-gel and chemical precipitation method) for the quick production of TiO₂ nanoparticles with very fine particle properties. The X-ray powder diffraction analysis (XRPD) and transmission electron microscopy (TEM) were two techniques used for analysing the properties related to structure and particle morphology of the resultant samples. It was observed that the particles formed by using continuous flow route were less agglomerated, and particle size (~ 6?nm) was smaller in comparison with others obtained using sol-gel (~ 9?nm) and chemical precipitation method (~ 15?nm). X-ray diffraction impressions established the generation of Anatase phase with preferential [101] dimension. Zeta potential computations were taken to inspect the colloidal stability of nanoparticles. Antimicrobial nature of TiO₂ nano-samples was analyzed by using various bacterial and fungal strains. The nanostructured TiO₂ particles confirmed outstanding uniformity with respect to chemical and structure. This new ceramic substance with strong antimicrobial activity promised magnificent potential in bone tissue engineering.     

Modified Reynolds Equation for Different Types of Finite Plates with the Combined Effect of MHD and Couple Stresses

We make an effort to analyze the behavior of squeeze film characteristics of different finite plates with couple stress fluid in the presence of a transverse magnetic field. On the basis of the Stokes couple stress fluid model and hydromagnetic flow model, a modified Reynold's equation is derived, which is solved by using appropriate boundary conditions to obtain squeeze film pressure, load-carrying capacity, and squeeze film time. The graphical representation of the results suggests that the different bearing systems register an enhanced performance with couple stresses compared to that of a bearing system working with a conventional lubricant in the presence of a transverse magnetic field. It is observed that the effect of applied magnetic field on the squeeze film lubrication between different finite plates with conducting couple stress fluids is to increase the load-carrying capacity significantly and to delay the time of approach compared to the corresponding nonconducting Newtonian case. It is seen that for all of the finite plates of different shapes, the circular shape gives the maximum load and time.     

Computation of the flow and thermal fields in a thermoacoustic refrigerator

The hydro- and thermodynamic processes near and within two-dimensional stack plates are simulated by numerical solution of the unsteady compressible Navier–Stokes, continuity, energy equations, and the equation of state (for air as the working fluid). The stack is assumed to consist of flat plates of equal thickness. The second order mean velocity field is computed in the neighborhood of the stack plates. In the stack plate extremities the vortical mean flow is observed which is due to the abrupt change of a slip condition to a no-slip velocity boundary condition. The temperature of the stack is governed by the energy equation; therefore the entire problem is treated as a conjugate heat transfer problem. The temperature fields in the neighborhood of the solid stack plate are also observed. From the location of the heat exchangers in Fig. 1(a), it is obvious that knowledge of the flow and thermal fields at the edges of the stack plates is the key for the development of a systematic design methodology for heat exchangers in thermoacoustic devices.     

A new approach for image encryption and watermarking based on substitution box over the classes of chain rings

Multimedia Tools and Applications - The meanings of passing information from one side to other side by a conventional way is been changed because of internet and communication technology. The...