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101.
Atsuko Kimura Kazuhiko Namekata Xiaoli Guo Chikako Harada Takayuki Harada 《International journal of molecular sciences》2016,17(9)
Neurotrophic factors play key roles in the development and survival of neurons. The potent neuroprotective effects of neurotrophic factors, including brain-derived neurotrophic factor (BDNF), ciliary neurotrophic factor (CNTF), glial cell-line derived neurotrophic factor (GDNF) and nerve growth factor (NGF), suggest that they are good therapeutic candidates for neurodegenerative diseases. Glaucoma is a neurodegenerative disease of the eye that causes irreversible blindness. It is characterized by damage to the optic nerve, usually due to high intraocular pressure (IOP), and progressive degeneration of retinal neurons called retinal ganglion cells (RGCs). Current therapy for glaucoma focuses on reduction of IOP, but neuroprotection may also be beneficial. BDNF is a powerful neuroprotective agent especially for RGCs. Exogenous application of BDNF to the retina and increased BDNF expression in retinal neurons using viral vector systems are both effective in protecting RGCs from damage. Furthermore, induction of BDNF expression by agents such as valproic acid has also been beneficial in promoting RGC survival. In this review, we discuss the therapeutic potential of neurotrophic factors in retinal diseases and focus on the differential roles of glial and neuronal TrkB in neuroprotection. We also discuss the role of neurotrophic factors in neuroregeneration. 相似文献
102.
Ahmed J. Samed Takayuki Tanaka Keita Ikeue Masato Machida 《Topics in Catalysis》2010,53(7-10):591-596
Catalytic NO–H2–CO–O2 reaction was studied over Pt-supported Ln-incorporated FSM-16 (Ln = La, Ce and Pr). Pr-FSM-16 exhibited the highest activity for NO x reduction at ≤200 °C. Pr has an effect of increasing the basicity to promote the oxidative adsorption of NO, which is a key for efficient de-NO x . 相似文献
103.
Takayuki Saito Warunee Klinklai Yoshimasa Yamamoto Seiichi Kawahara Yoshinobu Isono Yoshito Ohtake 《应用聚合物科学杂志》2010,115(6):3598-3604
Reaction between epoxidized natural rubber and poly(L ‐lactide) (PLLA) was investigated quantitatively in terms of conversion of the epoxidized natural rubber. The epoxidized natural rubber was prepared by epoxidation of high ammonia natural rubber (HA‐NR) or deproteinized natural rubber (DPNR) with peracetic acid followed by depolymerization with ammonium persulfate. The resulting liquid HA‐NR having epoxy group (LENR) or liquid DPNR having epoxy group (LEDPNR) were subjected to heating at 473 K for 20 min, after blending with PLLA. The products were characterized through morphology observation, DSC measurement, and 1H‐NMR spectroscopy. The conversions of the rubbers were estimated from intensity ratio of signals in 1H‐NMR spectrum for the products after removing unreacted rubber with toluene. Difference in the estimated conversion between the LENR/PLLA and LEDPNR/PLLA blends was interpreted in relation to proteins present in the rubber. © 2009 Wiley Periodicals, Inc. J Appl Polym Sci, 2010 相似文献
104.
105.
Atsushi Miyagi Takayuki Suzuki Hiroshi Nabetani Mitsutoshi Nakajima 《Food and Bioproducts Processing》2013,91(4):507-514
The present study systemically decolorized soy sauce using a membrane process to analyze the separation mechanism. An ultrafiltration (UF) membrane (NTU-2120) exhibited only slight decolorization ability. A nanofiltration (NF) membrane with a lower molecular weight cut-off and produced by sulfonated polysulfone (NTR-7400 series) rather than polyvinyl alcohol/polyamide (NTR-7250) had higher decolorization ability. The NF membranes rejected total nitrogen by 17–24%, unsalted soluble solid content by 24–32%, reducing sugar by 25–43%, and amino acids by 10–25%. The NTR-7400 series membrane rejected lactic acid by 6–9%, and pyroglutamic acid by 11–21%; other quality indexes were maintained. In the NF membrane processes, higher rejection of acidic amino acids than neutral and base amino acids was observed. The separation performance was governed by the electrical effect as well as the sieve effect. Soy sauce color could be controlled by blending NF membrane-processed soy sauce with feed soy sauce. Color can be matched to preference in accordance with dishes by suitably blending NF membrane-processed soy sauce with feed soy sauce. 相似文献
106.
Mikito Kitayama Takayuki Narushima reas M. Glaeser 《Journal of the American Ceramic Society》2000,83(10):2572-2583
The rate at which a facetted tetragonal cavity of nonequilibrium shape approaches a cubic equilibrium (Wulff) shape via surface diffusion was modeled. The shape relaxation rate of a facetted stretched cylinder was also modeled. For the first geometry, only an approximate solution based on linearizing the mean potential difference between the source and sink facets was obtained. For the stretched cylinder, both an approximate and an exact solution can be obtained; the approximate solution underestimates the evolution rate by a factor of ∼2. To assess the applicability of the models, nonequilibrium shape pores of identical initial geometry (∼20 μm × 20 μm × 0.5 μm) were introduced into (0001), {10[Onemacr]2}, {1120}, and {100} surfaces of sapphire single crystals using microfabrication techniques, ion-beam etching, and hot pressing. The large (∼20 μm × 20 μm) faces of the pore are low-index surfaces whose nature is dictated by the wafer orientation. A series of anneals was performed at 1900°C, and the approach of the pore shape to an equilibrium shape was monitored. The kinetics of shape evolution are highly sensitive to the crystallographic orientation and stability of the low-index surface that dominates the initial pore shape. The measured variations of the pore aspect ratio were compared to those predicted by the kinetic model. The observations suggest that when the initial bounding surface is unstable, shape relaxation may be controlled by diffusion. However, surface-attachment-limited kinetics (SALK) appears to play a major role in determining the pore shape evolution rate in cases where the initial bounding surfaces have orientations that are part of the Wulff shape. 相似文献
107.
Kazuya Aida Yasuhiko Benino Vesselin Dimitrov Takayuki Komatsu Ryuji Sato 《Journal of the American Ceramic Society》2000,83(5):1192-1198
The kinetics of enthalpy relaxation (recovery) at the glass transition in x K2 O·(20− x )MgO·80TeO2 glasses has been examined from heat capacity measurements using differential scanning calorimetry to clarify the features of the structural relaxation in ternary TeO2 -based glasses. Ternary glasses such as 10K2 O·10MgO·80TeO2 show high thermal resistance against crystallization compared with binary glasses. The degree of fragility m estimated from the activation energy for viscous flow E η and the glass transition temperature T g is m = 55–62, indicating a fragile character in TeO2 -based glasses. Large heat capacity changes of 43.1–48.2 J·mol−1 ·K−1 are also observed at the glass transition. The activation energy for enthalpy relaxation Δ H is evaluated from the cooling rate dependence of the limiting fictive temperature, and values of Δ H = 897–1268 kJ·mol−1 are obtained. Negative deviation from additivity in Δ H is also observed. Values of the Kovacs–Aklonis–Huchinson–Ramos (KAHR) parameter θ estimated from Δ H and T g are 0.33–0.42 K−1 . It has been proposed that ternary glasses have more homogeneous and constrained glass structure compared with binary glasses. 相似文献
108.
Stress fields on elastic-creep bi-material interfaces with different geometry of the interface edge are analyzed by finite element method. The results reveal that the stress highly concentrates near the interface edge at the loading instant and it gradually decreases as the creep-dominated zone expands from the small-scale creep to the large-scale creep. The stress singularity due to creep which resembles the HRR stress singularity appears near the interface edge in all cases. The stress intensity near the interface edge time-dependently decreases and becomes constant when the transition reaches the steady state. The magnitude is scarcely influenced by the edge shape of elastic material, though it depends on the edge shape of creep material. The stress intensity during the transition can be approximately predicted by the J-integral at the loading instant. 相似文献
109.
Riho Kataishi Takayuki Ikeda Toshiki Sasaki Kouhei Toyotaka Daiki Nakamura Hiroyuki Miyake Yuji Iwaki Kazunori Watanabe Yuichi Yanagisawa Hisao Ikeda Harue Nakashima Nobuharu Ohsawa Shingo Eguchi Satoshi Seo Yoshiharu Hirakata Shunpei Yamazaki Daisuke Kurosaki Masakatsu Ohno Chris Bower Darryl Cotton Andrew Matthews Piers Andrew Catalin Gheorghiu Johan Bergquist 《Journal of the Society for Information Display》2014,22(8):381-392
In this study, white organic electroluminescent devices with microcavity structures were developed. A flexible high‐resolution active‐matrix organic light‐emitting diode display with low power consumption using red, green, blue, and white sub‐pixels formed by a color‐filter method was fabricated. In addition, a side‐roll touch display was developed in combination with a capacitive flexible touch screen. 相似文献
110.
Takayuki Ohba 《Journal of Electronic Materials》2001,30(4):314-319
In order for ultra-large-integrated (ULSI) circuits manufacturing to minimize the Cost of Ownership (CoO) aspect in the wiring
process and realize fabricating semiconductor devices over 100 nm node, several Cu/low-k wiring technologies have been proposed.
The evidential criteria in choosing the most probable one are physical or material limitation and requirements from manufacturing.
A development of module processes (e.g., processing from low-k dielectrics to metal CMP) with proven equipment and material
is an appropriate approach and has a high potential in overcoming those difficulties. In this paper, an advantage of dual
Damascene Cu wiring accompanied with low-k (dielectric constant ∼2.7) and prediction of 100 nm Cu wiring module will be discussed. 相似文献