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91.
Multimedia Tools and Applications - The arithmetic properties of a finite field have a remarkable impact on the security features of symmetric and asymmetric cryptosystems. Conventionally, in... 相似文献
92.
Shaimaa M. Aboukhatwa Dr. Thomas W. Hanigan Taha Y. Taha Dr. Jayaprakash Neerasa Dr. Rajeev Ranjan Dr. Eman E. El-Bastawissy Dr. Mohamed A. Elkersh Prof. Dr. Tarek F. El-Moselhy Prof. Dr. Jonna Frasor Prof. Dr. Nadim Mahmud Prof. Dr. Alan McLachlan Prof. Dr. Pavel A. Petukhov 《ChemMedChem》2019,14(11):1096-1107
Histone deacetylase (HDAC) activity is modulated in vivo by post-translational modifications and formation of multiprotein complexes. Novel chemical tools to study how these factors affect engagement of HDAC isoforms by HDAC inhibitors (HDACi) in cells and tissues are needed. In this study, a synthetic strategy to access chemically diverse photoreactive probes (PRPs) was developed and used to prepare seven novel HDAC PRPs 9 – 15 . The class I HDAC isoform engagement by PRPs was determined in biochemical assays and photolabeling experiments in live SET-2, HepG2, HuH7, and HEK293T cell lines and in mouse liver tissue. Unlike the HDAC protein abundance and biochemical activity against recombinant HDACs, the chemotype of the PRPs and the type of cells were key in defining the engagement of HDAC isoforms in live cells. Our findings suggest that engagement of HDAC isoforms by HDACi in vivo may be substantially modulated in a cell- and tissue-type-dependent manner. 相似文献
93.
94.
A Monte Carlo source model using PENELOPE was developed to investigate different tritiated metals in order to design a better radioisotope source for betavoltaic batteries. The source model takes into account the self‐absorption of beta particles in the source which is a major factor for an efficient source design. The average beta energy, beta flux, source power output, and source efficiency were estimated for various source thicknesses. The simulated results for titanium tritide with 0° and 90° angular distributions of beta particles were validated with experimental results. The importance of the backscattering effect due to isotropic particle emission was analyzed. The results showed that the normalized average beta energy increases with the source thickness, and it reaches peak energy depending on the density and the specific activity of the source. The beta flux and power output also increase with increasing source thickness. However, the incremental increase in beta flux and power output becomes minimal for higher thicknesses, as the source efficiency decreases significantly at higher thicknesses due to the self‐absorption effect. Thus, a saturation threshold is reached. A low‐density source material such as beryllium tritide provided a higher power output with higher efficiency. A maximum power output of approximately 4 mW/cm3 was obtained for beryllium tritide with SiC. A form factor approach was used to estimate the optimum source thickness. The optimum source thickness was found near the thickness where the peak beta particle average energy occurs. 相似文献
95.
96.
Shah Dawood Shah Tariq Jamal Sajjad Shaukat 《Multidimensional Systems and Signal Processing》2020,31(3):885-905
Multidimensional Systems and Signal Processing - Algebraic structures and their hardware–software implementation gain considerable attention in the field of information security and coding... 相似文献
97.
Mohammad A. U. Khan Tariq M. Khan Donald G. Bailey 《Signal, Image and Video Processing》2018,12(3):513-521
The enhancement of coherent flow-like structures is desired for many image processing tasks, such as segmentation and feature detection. This task can be accomplished in a natural way by adopting anisotropic diffusion filtering using a diffusion matrix adapted to the local structure. This method is referred to as coherence-enhancing diffusion (CED). The performance of CED can be analyzed by observing the evolution of the orientation field (OF) associated with an evolving diffusion matrix. It was revealed from a series of experiments that the final OF from a CED-enhanced image sometimes strays from its true underlying OF (marked by a human expert), degrading its performance. In this paper, a strategy is proposed which repeatedly cleans the OF associated with a diffusion matrix. Thus, for every iteration of CED, its OF is diffused separately until it converges and is then fed back to the CED process to move forward. This hypothesis is tested with the motive of getting an enhanced CED performance. The proposed scheme is validated using fingerprint data, and their numerical results are displayed. 相似文献
98.
In this article, we propose a new shape from focus (SFF) method to estimate 3D shape of microscopic objects using surface orientation cue of each object patch. Most of the SFF algorithms compute the focus value of a pixel from the information of neighboring pixels lying on the same image frame based on an assumption that the small object patch corresponding to the small neighborhood of a pixel is a plane parallel to the focal plane. However, this assumption fails in the optics with limited depth of field where the neighboring pixels of an image have different degree of focus. To overcome this problem, we try to search the surface orientation of the small object patch corresponding to each pixel in the image sequence. Searching of the surface orientation is done indirectly by principal component analysis. Then, the focus value of each pixel is computed from the neighboring pixels lying on the surface perpendicular to the corresponding surface orientation. Experimental results on synthetic and real microscopic objects show that the proposed method produces more accurate 3D shape in comparison to the existing techniques. 相似文献
99.
Zia Ul-Haq Zertasha Ramzan Salman Tariq Syeda Adila Batool Muhammad Ali Javed Sami 《International journal of remote sensing》2018,39(2):544-564
This article presents a comparison analysis of OMIT (Ozone Monitoring Instrument retrieved overpass total ozone column (TOC)), and DOST (Dobson Ozone Spectrophotometer observed TOC) over Delhi during a period from October 2004 to June 2011. Megacity Delhi, located in Indo-Gangetic Basin, is an important site for comparison of ground-based and satellite retrieved TOCs due to significant anthropogenic emissions of ozone precursors, large shift in seasons, and large-scale crop residue burning in the region. DOST and OMIT data show an overall bias of 3.07% and significant correlation with coefficient of determination R2 = 0.73. Large seasonal fluctuations in the biases and correlations have been observed ranging from 2.46% (winter) to 3.82% (spring), and R2 = 0.84 (winter) to R2 = 0.09 (summer), respectively. The large biases are attributed to changes in temperature, cloud cover, pollutants emissions from urban area, and crop-residue burning events. We also find notable variations in correlations between the datasets due to the varying burden of absorbing aerosols from open field crop-residue burning. The R2 has changed from 0.67 (for aerosol optical depth, AOD 1.5–3.5) to 0.77 (for AOD 0–0.99). The dependence of the bias on solar zenith angle, cloud fraction, and satellite distance is also discussed. A simple linear regression analysis is applied to check the linkage between DOST and OMIT. The influence of atmospheric air temperature and relative humidity on OMIT at different pressure levels between 1000 and 20 hPa has been discussed. 相似文献
100.
Zuoting Yang Ke Yang Yuhong Cui Tariq Shah Mudasir Ahmad Qiuyu Zhang Baoliang Zhang 《材料科学技术学报》2021,74(15):203-215
Nowadays,the employing of molecular imprinting technique in the analysis and separation of proteins from complex biological samples has been widely favored by researchers.To enrich the types of surface protein imprinted materials and expand the application fields of graphene materials,novel surface molecular imprinted polymers (MIPs) based on magnetic graphene microspheres Fe304@rGO@MIPs are first synthesized in this paper.Fe304@rGO@MIPs are prepared by oxidative self-polymerization of dopamine on the surface of magnetic graphene (Fe304@rGO) composite microspheres.Bovine serum albumin (BSA) is selected as protein template.Fe3O4@rGO microspheres with wrinkled flower-like structure are obtained by compounding Fe3O4 and graphene oxide in an appropriate ratio via the method of high-temperature reduction self-assembly.The microspheres exhibit promising dispersibility,high external surface area,rich pore structure,and sufficient magnetic properties.These advantages not only prevent the agglomeration of imprinted microspheres in the aqueous phase,which is conducive to contact and static adsorption,but also increase the amount of protein imprinting.Additionally,sufficient magnetic properties ensure fast and effective separation of the adsorbents.While the adsorption capacity is increased,the separation procedure becomes simple.The binding capacity of Fe304@rGO@MIPs for BSA can reach 317.58 mg/g within 60 min,and the imprinting factor (IF) is 4.24.More importantly,Fe3O4@rGO@MIPs can specifically recognize the target BSA from the mixed proteins and the actual sample.There is no significant decrease in the adsorption amount,IF,and magnetic properties after eight runs.It is promising to be used in the separation of proteins from the actual biological samples. 相似文献