Lack of effect of food on the steady state pharmacokinetics of BMS-181101, an antidepressant, in healthy subjects

An annual atmospheric pollen survey was performed for 14 consecutive years in the autumn at Sakado city, Saitama prefecture. The survey was performed on the transition of pollen dispersion of major allergen plants: ragweed (Ambrosia spp.), Humulus japonicus, Artemisia spp. and Gramineae. 1. Annual total pollen count of ragweed showed marked increases beginning from 1991. Total pollen count in 1991 was 8.8 times and that in 1996 was 18.6 times that in 1983. This increase is probably caused by marked proliferation of giant ragweed which is left without mowing as it is on a dry riverbed, and consequently produces much more pollen than short ragweed. 2. Annual increases in total pollen counts of other major plants which disperse their pollen in the same season as ragweed were 0.95 times in 1991 and 0.5 times in 1996 that in 1983 for Humulus japonicus, 0.68 times in 1991 and 1.5 times in 1996 that in 1983 for Artemisia spp. and 1.3 times in 1991 and 1.4 times in 1996 that in 1983 for Gramineae. None of these species showed a marked increase of pollen dispersion although they showed some annual variation. The above findings suggest that changes in the proliferous state of various allergenic plants due to environmental change should be considered with respect to characteristics of pollen allergy.     

Edge passivation and related electrical stability in silicon powerdevices

Factors governing long-term stability of silicon power devices are discussed with particular reference to a major failure mechanism observed in a thyristor device. The device failure was due to electrical instability during an electrical and thermal stability storage test, wherein it was observed that the reverse blocking voltage deteriorated under applied bias at the rated maximum junction temperature. The major cause of this failure was identified as lack of exhaust during the edge passivation and curing process due to which excessive chemical deposits are retained in the bevel region of the silicon element. This contributes to surface leakage current and, hence, a rapid degradation of the off-state characteristics. An orthogonal array experiment was employed to optimize the process factors and levels. The manufacturing process was then modified by incorporating an effective exhaust system in the passivant curing oven. This resulted in marked improvements in the electrical stability and manufacturing yield of this device     

Magnetic and transport properties of Laves phase Dy1−xMmxCo2 (x = 0–0.5) alloys

The influence of Mm substitution (Mm = mischmetal) on structural, transport and magnetic properties of (Dy_1?xMm_x)Co₂ (x = 0, 0.1, 0.2, 0.3, 0.4 and 0.5) alloys has been investigated by means of X-ray diffraction (XRD), temperature dependent electrical resistivity (ρ(T)), ac susceptibility (χ(T)) and thermopower (S(T)). XRD patterns show the formation of solid solutions crystallizing with cubic Laves (C15) type structure at room temperature. The pronounced discontinuities in the resistivity and thermopower at Curie temperature (T_C) are explained based on the suppression of the spin-fluctuation contribution. The gradual decrease in T_C and sharpness of discontinuities in ρ(T) and S(T) with increasing Mm substitution has been discussed.     

Peristaltic transport in an asymmetric channel with heat transfer — A note

The problem of heat transfer for the motion of a viscous incompressible fluid induced by travelling sinusoidal waves has been analytically investigated for a two-dimensional asymmetrical channel. The channel asymmetry is produced by choosing the peristaltic wave train on the walls to have different amplitudes and phase. The flow is investigated in a wave frame of reference moving with the velocity of the wave. The momentum and energy equations have been linearized under long-wavelength and low-Reynolds number assumptions and closed form expressions for temperature and coefficient of heat transfer have been derived. The effect of Hartmann number, Eckert number, width of the channel and phase angle on temperature and coefficient of heat transfer are discussed numerically and explained graphically.     

An Efficient,Stable and Reusable Palladium Nanocatalyst: Chemoselective Reduction of Aldehydes with Molecular Hydrogen in Water

Palladium nanoparticles (Pd‐BNP) stabilized by a binaphthyl‐backbone can be efficiently used for the chemoselective reduction of aldehydes in the presence of hydrogen at room temperature in water. The Pd‐BNP catalyst is easily recovered and reused for five catalytic cycles.

     

Factors affecting the puffing quality of paddy

Histological studies showed that in good puffing varieties of paddy the aleurone layer was thin and weak at the specific points of bursting while the clearance between the husk and kernel was large and the grain was easily shelled. In the poor puffing varieties the aleurone was uniformly thicker along the peripheral section while clearance between husk and grain was smaller and the grains were relatively more difficult to shell. Optimum maturity of grains at an average grain moisture of 20 to 24% was essential for getting maximum puffing. Delayed harvesting caused sun checks and reduced overall puffing expansion. Sun checks caused by severe drying in the sun produced a similar effect. High grain density was associated with better puffing.     

Impact of information sharing in hierarchical decision-making framework in manufacturing supply chains

This paper presents a comprehensive framework for the analysis of the impact of information sharing in hierarchical decision-making in manufacturing supply chains. In this framework, the process plan selection and real-time resource allocation problems are formulated as hierarchical optimization problems, where problems at each level in the hierarchy are solved by separate multi-objective genetic algorithms. The considered multi-objective genetic algorithms generate near optimal solutions for NP-hard problems with less computational complexity. In this work, a four-level hierarchical decision structure is considered, where the decision levels are defined as enterprise level, shop level, cell level, and equipment level. Using this framework, the sources of information affecting the achievement of best possible decisions are then identified at each of these levels, and the extent of their effects from sharing them are analyzed in terms of the axis, degree and the content of information. The generality and validity of the proposed approach have been successfully tested for diverse manufacturing systems generated from a designed experiment.     

Kinetics of emitted mass—A study with three dry powder inhaler devices

The purpose of this study was to understand the kinetics of emptying of micronised salbutamol sulphate (SS) and lactohale 300 (LH300) under varying air flow rates (30–180 L min⁻¹) from three dry powder inhaler devices, Rotahaler^® (RH), Monodose Inhaler^® (MI) and Handihaler^® (HH). Aerosol concentration vs. time profiles, determined through real-time laser diffraction particle sizing, demonstrated that the majority of the powder from RH was emitted within one second while a more prolonged aerosolisation was observed from MI and HH. Peak aerosol concentrations were achieved more rapidly from RH compared to MI for both SS and LH300. Calculated cumulative emitted mass (CCEM) vs. time profiles were obtained from the aerosol concentration vs. time profiles and the emitted mass and the rate of CCEM (k_CCEM), estimated from a modelling approach, increased with increasing air flow rates. The k_CCEMvs. air flow rate profiles of SS and LH300 were significantly different at high air flow rates. The k_CCEM was highest from RH and lowest from MI. Differences in k_CCEM between the devices were related to capsule aperture size while the differences between the materials were due to the powder bed structure. This approach provided an understanding of the rate at which powder mass emptied from dry powder inhaler devices and was proposed to be a powerful development tool for the future powder inhalers.