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排序方式: 共有473条查询结果,搜索用时 390 毫秒
101.
102.
Ultra thin nickel transparent electrodes 总被引:1,自引:0,他引:1
Stefano Giurgola Anabel Rodriguez Luis Martinez Paolo Vergani Federico Lucchi Sarah Benchabane Valerio Pruneri 《Journal of Materials Science: Materials in Electronics》2009,20(Z1):181-184
Transparent electrodes made of ultra thin metals have recently been demonstrated with performances comparable to those offered
by transparent conductive oxides (TCOs), which are traditionally used in applications such as photovoltaic cells, light emitting
devices, photodetectors and electro-optical modulators. In this work we report highly uniform, optically transparent and electrically
conductive nickel films. Their good performance, combined with low cost and simplicity in processing, make ultra thin Ni films
highly competitive, even with respect to the latest developments in TCO technology. Nickel films can be easily incorporated
into an industrial process flow and could therefore be an attractive alternative to TCOs in many industrial applications. 相似文献
103.
The improvement of passive fire protection of storage vessels is a key factor to enhance safety among the LPG distribution chain. A thermal and mechanical model based on finite elements simulations was developed to assess the behaviour of full size tanks used for LPG storage and transportation in fire engulfment scenarios. The model was validated by experimental results. A specific analysis of the performance of four different reference coating materials was then carried out, also defining specific key performance indicators (KPIs) to assess design safety margins in near-miss simulations. The results confirmed the wide influence of coating application on the expected vessel time to failure due to fire engulfment. A quite different performance of the alternative coating materials was evidenced. General correlations were developed among the vessel time to failure and the effective coating thickness in full engulfment scenarios, providing a preliminary assessment of the coating thickness required to prevent tank rupture for a given time lapse. The KPIs defined allowed the assessment of the available safety margins in the reference scenarios analyzed and of the robustness of thermal protection design. 相似文献
104.
105.
Valerio Chiurchi Marta Tiberi Alessandro Matteocci Federico Fazio Hasibullah Siffeti Stefano Saracini Nicola Biagio Mercuri Giuseppe Sancesario 《International journal of molecular sciences》2022,23(11)
Lipids are not only constituents of cellular membranes, but they are also key signaling mediators, thus acting as “bioactive lipids”. Among the prominent roles exerted by bioactive lipids are immune regulation, inflammation, and maintenance of homeostasis. Accumulated evidence indicates the existence of a bidirectional relationship between the immune and nervous systems, and lipids can interact particularly with the aggregation and propagation of many pathogenic proteins that are well-renowned hallmarks of several neurodegenerative disorders, including Alzheimer’s (AD) and Parkinson’s (PD) diseases. In this review, we summarize the current knowledge about the presence and quantification of the main classes of endogenous bioactive lipids, namely glycerophospholipids/sphingolipids, classical eicosanoids, pro-resolving lipid mediators, and endocannabinoids, in AD and PD patients, as well as their most-used animal models, by means of lipidomic analyses, advocating for these lipid mediators as powerful biomarkers of pathology, diagnosis, and progression, as well as predictors of response or activity to different current therapies for these neurodegenerative diseases. 相似文献
106.
Vincenzo Fiorentino Pietro Tralongo Maurizio Martini Silvia Betti Elena Rossi Francesco Pierconti Valerio De Stefano Luigi Maria Larocca 《International journal of molecular sciences》2022,23(14)
Philadelphia-negative chronic myeloproliferative neoplasms (MPNs) represent a group of hematological disorders that are traditionally considered as indistinct slow progressing conditions; still, a subset of cases shows a rapid evolution towards myelofibrotic bone marrow failure. Specific abnormalities in the megakaryocyte lineage seem to play a central role in this evolution, especially in the bone marrow fibrosis but also in the induction of myeloproliferation. In this review, we analyze the current knowledge of prognostic factors of MPNs related to their evolution to myelofibrotic bone marrow failure. Moreover, we focused the role of the megakaryocytic lineage in the various stages of MPNs, with updated examples of MPNs in vitro and in vivo models and new therapeutic implications. 相似文献
107.
Elisa Boschetti Leonardo Caporali Roberto DAngelo Carolina Malagelada Anna Accarino Maria Teresa Dotti Roberta Costa Giovanna Cenacchi Loris Pironi Rita Rinaldi Vincenzo Stanghellini Stefano Ratti Lucia Manzoli Valerio Carelli Roberto De Giorgio 《International journal of molecular sciences》2022,23(15)
mitochondrial neuro-gastrointestinal encephalomyopathy (MNGIE) is a rare genetic disorder characterized by thymidine phosphorylase (TP) enzyme defect. The absence of TP activity induces the imbalance of mitochondrial nucleotide pool, leading to impaired mitochondrial DNA (mtDNA) replication and depletion. Since mtDNA is required to ensure oxidative phosphorylation, metabolically active tissues may not achieve sufficient energy production. The only effective life-saving approach in MNGIE has been the permanent replacement of TP via allogeneic hematopoietic stem cell or liver transplantation. However, the follow-up of transplanted patients showed that gut tissue changes do not revert and fatal complications, such as massive gastrointestinal bleeding, can occur. The purpose of this study was to clarify whether the reintroduction of TP after transplant can recover mtDNA copy number in a normal range. Using laser capture microdissection and droplet-digital-PCR, we assessed the mtDNA copy number in each layer of full-thickness ileal samples of a naive MNGIE cohort vs. controls and in a patient pre- and post-TP replacement. The treatment led to a significant recovery of gut tissue mtDNA amount, thus showing its efficacy. Our results indicate that a timely TP replacement is needed to maximize therapeutic success before irreversible degenerative tissue changes occur in MNGIE. 相似文献
108.
F Carneiro Mussi 《Canadian Metallurgical Quarterly》1996,30(2):254-266
The authoress presents a literature review on the comfort theme and analytically describes conceptualizations, discovered definitions, and studies focusing comfort from the subjects' perspective; a number of existing gaps within this area of knowledge are emphasized and suggestions are made concerning the important aspects in the research development. 相似文献
109.
Tommaso Roscilde Paola Verrucchi Andrea Fubini Stephan Haas Valerio Tognetti 《Journal of Low Temperature Physics》2005,140(3-4):293-302
We perform an extensive quantum Monte Carlo investigation of entanglement properties in quantum spin systems close to or at a quantum critical point. Making use of the Stochastic Series Expansion method, we can systematically estimate the bipartite entanglement of the ground-state wavefunction in a large class of anisotropic spin models on unfrustrated lattices and in a uniform magnetic field. The behavior of the entanglement estimators as a function of the field shows remarkable universal features independent of the lattice dimensionality, marking both the occurrence of a field-induced quantum phase transition and of an exactly factorized state.PACS numbers: 03.67.Mn, 75.10.Jm, 73.43.Nq, 05.30.-d 相似文献
110.
C Sené A Bout JL Imler H Schultz JM Willemot V Hennebel C Zurcher D Valerio D Lamy A Pavirani 《Canadian Metallurgical Quarterly》1995,6(12):1587-1593
At present, it is conceivable that gene therapy of the cystic fibrosis airway epithelium is possible using the direct transfer of a functional human cystic fibrosis transmembrane conductance regulator (CFTR) gene to a wide variety of patients' tracheo-bronchial cells. Here we describe a novel approach (aerosolization) to deliver a replication-deficient adenovirus carrying the CFTR gene (Ad.CFTR) to the airways. Results obtained in vitro and in Rhesus monkeys suggest that the delivery of recombinant adenovirus as an aerosol is feasible and is not associated with severe toxicity after single or double administration depending on the Ad.CFTR dose. This study supports the concept of aerosolization as a delivery method for adenovirus-mediated lung gene therapy. 相似文献