Synthesis, structure determination and magnetic susceptibilities of the oxides Ln3Li5Sb2O12 (Ln ≠ Pr, Nd, Sm)

The oxides Ln₃Li₆Sb₂O₁₂ (Ln≠Pr, Nd, Sm) were prepared in air by heating a mixture of Ln₂O₃, LiNO₃and Sb₂O₃ in the temperature range 1023–1243 K. Lattice parameters as well as atomic coordinates in the space group 12,3 (Z≠8) are established from X-ray powder diffraction data by the Rietveld method. Magnetic susceptibilities from 4.2 to 300 K follow a Curie-Weiss law above 50 K (Ln≠Pr) or 70 K (Ln≠Nd). This is attributed to the splitting of the ground state associated with the Ln³⁺ ions by the influence of the crystal field. The magnetic moments, 3.54 and 3.61 μ_D for praseodymium and neodymium respectively, agree with those calculated by Hund's formula. The Sm³⁺ behaviour can be explained by taking into account that the splitting of the multiplets is not too large compared to kT. The magnetic moment observed at room temperature for this cation is 1.6 μ_B.     

OBIWAN: design and implementation of a middleware platform

Programming distributed applications supporting data sharing is very hard. In most middleware platforms, programmers must deal with system-level issues for which they do not have the adequate knowledge, e.g., object replication, abusive resource consumption by mobile agents, and distributed garbage collection. As a result, programmers are diverted from their main task: the application logic. In addition, given that such system-level issues are extremely error-prone, programmers spend inumerous hours debugging. We designed, implemented, and evaluated a middleware platform called OBIWAN that releases the programmer from the above mentioned system-level issues. OBIWAN has the following distinctive characteristics: 1) allows the programmer to develop applications using either remote object invocation, object replication, or mobile agents, according to the specific needs of applications, 2) supports automatic object replication (e.g., incremental on-demand replication, transparent object faulting and serving, etc.), 3) supports distributed garbage collection of useless replicas, and 4) supports the specification and enforcement of history-based security policies well adapted to mobile agents needs (e.g., preventing abusive resource consumption).     

Prevalence of several cardiovascular risk factors in a population in the municipality of Viseu

STUDY OBJECTIVE: To assess the prevalence of the main changeable cardiovascular risk factors (hypertension, hypercholesterolemia and smoking) in the population of the Viseu municipality. MATERIAL AND METHODS: The population was obtained through a publicity campaign in local radios and on lighted placards in the town of Viseu. We chose a set of volunteers above 20 years of age, who answered a questionnaire about smoking habits, academic qualifications, profession and residence. After the inquiry, the total cholesterol and blood pressure were determined. We considered hypertension (HBP) values > or = 140/90 mmHg and hypercholesterolemia > 200 mg/dl. RESULTS: 1852 persons were inquired (3.2% of the population of the Viseu municipality) 1173 of which were females. According to the age groups, we verified that the ages between 50 and 69 years represented 47.9% of the total amount of volunteers. In what concerns smoking habits, we found a prevalence of 9.1% (15.9% in males and 5.2% in females). In the study of the prevalence of HBP we found a value of 38.5%, higher in males (42.8%) than in females (35.9%). The prevalence of hypercholesterolemia found was 34.9% (no significant differences between the sexes). CONCLUSION: In comparison with other studies carried out in the Portuguese population, a low prevalence of smoking habits, high hypertension and similar hypercholesterolemia were found.     

Heat transfer coefficient of a snow bag

In snow shooting, pressurised liquid carbon dioxide is injected via a lance into a permeable snow bag mounted near the ceiling of an insulated transport container. The decrease in pressure causes the liquid carbon dioxide to convert to “snow” and vapour inside the snow bag. The snow bag acts as a phase separator, allowing the sublimated snow to keep the preserving temperature inside a container. In this paper the heat transfer coefficient of such a snow bag was determined experimentally. The average heat transfer coefficient was found to be 3.80 Wm⁻² K⁻¹.     

Biodegradation and effect of formaldehyde and phenol on the denitrification process

Formaldehyde and phenol biodegradation during the denitrification process was studied at lab-scale, first in anoxic batch assays and then in a continuous anoxic reactor. The biodegradation of formaldehyde (260 mgl(-1)) as single carbon source and at phenol concentrations ranging from 30 to 580 mgl(-1) was investigated in batch assays, obtaining an initial biodegradation rate around 0.5g CH(2)OgVSS(-1)d(-1). With regard to phenol, its complete biodegradation was only observed at initial concentrations of 30 and 180 mgl(-1). The denitrification process was inhibited at phenol concentrations higher than 360 mgl(-1). Studies were also done using a continuous anoxic upflow sludge blanket reactor in which formaldehyde removal efficiencies above 99.5% were obtained at all the applied formaldehyde loading rates, between 0.89 and 0.14g COD (CH(2)O)l(-1)d(-1). The phenol loading rate was increased from 0.03 to 1.3g COD (C(6)H(6)O)l(-1)d(-1). Phenol removal efficiencies above 90.6% were obtained at phenol concentrations in the influent between 27 and 755 mgl(-1). However, when the phenol concentration was increased to 1010 mgl(-1), its removal efficiency decreased. Denitrification percentages around 98.4% were obtained with phenol concentrations in the influent up to 755 mgl(-1). After increasing phenol concentration to 1010 mgl(-1), the denitrification percentage decreased because of the inhibition caused by phenol.     

Role of Cellulose Ether Polymers on Ibuprofen Release from Matrix Tablets

Cellulose derivatives are the most frequently used polymers in formulations of pharmaceutical products for controlled drug delivery. The main aim of the present work was to evaluate the effect of different cellulose substitutions on the release rate of ibuprofen (IBP) from hydrophilic matrix tablets. Thus, the release mechanism of IBP with methylcellulose (MC25), hydroxypropylcellulose (HPC), and hydroxypropylmethylcellulose (HPMC K15M or K100M) was studied. In addition, the influence of the diluents lactose monohydrate (LAC) and β-cyclodextrin (β-CD) was evaluated. Distinct test formulations were prepared containing: 57.14% of IBP, 20.00% of polymer, 20.29% of diluent, 1.71% of talc lubricants, and 0.86% of magnesium stearate as lubricants. Although non-negligible drug-excipient interactions were detected from DSC studies, these were found not to constitute an incompatibility effect. Tablets were examined for their drug content, weight uniformity, hardness, thickness, tensile strength, friability, porosity, swelling, and dissolution performance. Polymers MC25 and HPC were found to be unsuitable for the preparation of this kind of solid dosage form, while HPMC K15M and K100M showed to be advantageous. Dissolution parameters such as the area under the dissolution curve (AUC), the dissolution efficiency (DE_{20 h}), dissolution time (t 50%), and mean dissolution time (MDT) were calculated for all the formulations, and the highest MDT values were obtained with HPMC indicating that a higher value of MDT signifies a higher drug retarding ability of the polymer and vice-versa. The analysis of the drug release data was performed in the light of distinct kinetic mathematical models—Kosmeyer-Peppas, Higuchi, zero-, and first-order. The release process was also found to be slightly influenced by the kind of diluent used.